Publications by authors named "Joseph Brady"

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Adaptation of Aglycosylated Monoclonal Antibodies for Improved Production in Komagataella phaffii.
Yuchen Yang, Neil C Dalvie, Joseph R Brady, Christopher A Naranjo, Timothy Lorgeree

Biotechnol Bioeng· February 2025

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Biodistribution and Tolerability of AAV-PHP.B-CBh- in Wistar Han Rats and Cynomolgus Macaques Reveal Different Toxicologic Profiles.
Xavier Palazzi, Ingrid D Pardo, Madhu P Sirivelu, Leah Newman, Steven W Kumpf, Joseph Brady

Hum Gene Ther· February 2022

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Engineered SARS-CoV-2 receptor binding domain improves manufacturability in yeast and immunogenicity in mice.
Neil C Dalvie, Sergio A Rodriguez-Aponte, Brittany L Hartwell, Lisa H Tostanoski, Andrew M Biedermann, Joseph R Brady

Proc Natl Acad Sci U S A· September 2021

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Development challenges associated with rAAV-based gene therapies.
Michael W Bolt, Joseph T Brady, Lawrence O Whiteley, K Nasir Khan

J Toxicol Sci· July 2021

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Modeling of copy number variability in Pichia pastoris.
Amos E Lu, Andrew J Maloney, Neil C Dalvie, Joseph R Brady, Kerry R Love

Biotechnol Bioeng· May 2021

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Molecular engineering improves antigen quality and enables integrated manufacturing of a trivalent subunit vaccine candidate for rotavirus.
Neil C Dalvie, Joseph R Brady, Laura E Crowell, Mary Kate Tracey, Andrew M Biedermann

Microb Cell Fact· May 2021

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Alternative hosts as the missing link for equitable therapeutic protein production.
Joseph R Brady, J Christopher Love

Nat Biotechnol· April 2021

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Mechanism of Thimerosal-Induced Structural Destabilization of a Recombinant Rotavirus P[4] Protein Antigen Formulated as a Multi-Dose Vaccine.
Kawaljit Kaur, Jian Xiong, Nishant Sawant, Sanjeev Agarwal, John M Hickey, Joseph R Brady

J Pharm Sci· March 2021

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Rapid Developability Assessments to Formulate Recombinant Protein Antigens as Stable, Low-Cost, Multi-Dose Vaccine Candidates: Case-Study With Non-Replicating Rotavirus (NRRV) Vaccine Antigens.
Nishant Sawant, Kawaljit Kaur, David A Holland, John M Hickey, Sanjeev Agarwal, Joseph R Brady

J Pharm Sci· March 2021

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Engineered SARS-CoV-2 receptor binding domain improves immunogenicity in mice and elicits protective immunity in hamsters.
Neil C Dalvie, Sergio A Rodriguez-Aponte, Brittany L Hartwell, Lisa H Tostanoski, Andrew M Biedermann, Joseph R Brady

bioRxiv· March 2021

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Integrated analyses of the microbiological, immunological and ontological transitions in the calf ileum during early life.
Tamsin Lyons, Hanne Jahns, Joseph Brady, Eóin O'Hara, Sinéad M Waters

Sci Rep· December 2020

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Identifying Improved Sites for Heterologous Gene Integration Using ATAC-seq.
Joseph R Brady, Melody C Tan, Charles A Whittaker, Noelle A Colant, Neil C Dalvie

ACS Synth Biol· September 2020

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Shared Learnings on the New EMA First-in-Human and Early Clinical Trial Guideline: Proceedings From a DIAlogue Session at DIA Europe 2018.
Jan Willem van der Laan, Charles T Benson, Walter Janssens, Jeroen Bos, Elke Stahl, Joseph T Brady

Ther Innov Regul Sci· March 2020

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Comparative genome-scale analysis of Pichia pastoris variants informs selection of an optimal base strain.
Joseph R Brady, Charles A Whittaker, Melody C Tan, D Lee Kristensen, Duanduan Ma

Biotechnol Bioeng· February 2020

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Host-Informed Expression of CRISPR Guide RNA for Genomic Engineering in .
Neil C Dalvie, Justin Leal, Charles A Whittaker, Yuchen Yang, Joseph R Brady

ACS Synth Biol· January 2020

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On-demand manufacturing of clinical-quality biopharmaceuticals.
Laura E Crowell, Amos E Lu, Kerry R Love, Alan Stockdale, Steven M Timmick, Joseph R Brady

Nat Biotechnol· October 2018

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Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.
Dominiek Smeets, Ian S Miller, Darran P O'Connor, Sudipto Das, Bruce Moran, Joseph Brady

Nat Commun· October 2018

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Development of an in vitro model of the early-stage bovine tuberculous granuloma using Mycobacterium bovis-BCG.
Laura Garza-Cuartero, Elaine McCarthy, Joseph Brady, Joseph Cassidy, Clare Hamilton

Vet Immunol Immunopathol· December 2015

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Effects of X-ray radiation on complex visual discrimination learning and social recognition memory in rats.
Catherine M Davis, Peter G Roma, Elwood Armour, Virginia L Gooden, Joseph V Brady

PLoS One· November 2015

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Drug-induced Skin Lesions in Cynomolgus Macaques Treated with Metabotropic Glutamate Receptor 5 (mGluR5) Negative Allosteric Modulators.
Gopinath S Palanisamy, John M Marcek, Gregg D Cappon, Jessica Whritenour, Christopher L Shaffer, Joseph T Brady

Toxicol Pathol· October 2015

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Improving the odds of success in drug discovery: choosing the best compounds for in vivo toxicology studies.
Travis T Wager, Bethany L Kormos, Joseph T Brady, Yvonne Will, Michael D Aleo

J Med Chem· December 2013

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Pregabalin induces hepatic hypoxia and increases endothelial cell proliferation in mice, a process inhibited by dietary vitamin E supplementation.
Kay A Criswell, Jon C Cook, Dennis Morse, Michael Lawton, Christopher Somps, Joseph Brady

Toxicol Sci· July 2012

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Mode of action associated with development of hemangiosarcoma in mice given pregabalin and assessment of human relevance.
Kay A Criswell, Jon C Cook, Zbigniew Wojcinski, David Pegg, James Herman, Joseph T Brady

Toxicol Sci· July 2012

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Neurobehavioral effects of head-only gamma-radiation exposure in rats.
Robert D Hienz, Joseph V Brady, Virginia L Gooden, Marcelo E Vazquez, Michael R Weed

Radiat Res· September 2008

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Raman and infrared fingerprint spectroscopy of peroxide-based explosives.
Jimmie Oxley, James Smith, Joseph Brady, Faina Dubnikova, Ronnie Kosloff

Appl Spectrosc· August 2008

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