Publications by authors named "Julien Sebag"

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Loss of melanocortin receptor accessory protein 2 in melanocortin-4 receptor neurons protect from obesity-associated autonomic and cardiovascular dysfunctions.
Deng Fu Guo, Paul A Williams, Alexis Olson, Donald A Morgan, Hussein Herz, Julien A Sebag

Cardiovasc Res· October 2025

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Inhibition of Unc119b improves insulin sensitivity through potentiation of Rac1 activation in skeletal muscle and brown adipose tissue.
Ayushi Mittal, Paul Buscaglia, Dhiraj Srivastava, Nikolai O Artemyev, Julien A Sebag

Mol Metab· October 2025

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Insulin sensitization by small molecules enhancing GLUT4 translocation.
Terry C Yin, Jonathan G Van Vranken, Dhiraj Srivastava, Ayushi Mittal, Paul Buscaglia, Julien A Sebag

Cell Chem Biol· August 2023

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Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2.
Terry C Yin, Ayushi Mittal, Paul Buscaglia, Wenxian Li, Julien A Sebag

J Biol Chem· January 2023

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MRAP2 inhibits β-arrestin recruitment to the ghrelin receptor by preventing GHSR1a phosphorylation.
Alix A J Rouault, Paul Buscaglia, Julien A Sebag

J Biol Chem· June 2022

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A putative long noncoding RNA-encoded micropeptide maintains cellular homeostasis in pancreatic β cells.
Mark Li, Fan Shao, Qingwen Qian, Wenjie Yu, Zeyuan Zhang, Julien Sebag

Mol Ther Nucleic Acids· December 2021

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Role of N-Linked Glycosylation in PKR2 Trafficking and Signaling.
Jissele A Verdinez, Julien A Sebag

Front Neurosci· August 2021

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Neutrophils Alter DNA Repair Landscape to Impact Survival and Shape Distinct Therapeutic Phenotypes of Colorectal Cancer.
Triet M Bui, Veronika Butin-Israeli, Hannah L Wiesolek, Meredith Zhou, Jake F Rehring, Julien A Sebag

Gastroenterology· July 2021

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The Insulinostatic Effect of Ghrelin Requires MRAP2 Expression in δ Cells.
Terry C Yin, Casey J Bauchle, Alix A J Rouault, Samuel B Stephens, Julien A Sebag

iScience· June 2020

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Reduced mRNA Expression of RGS2 (Regulator of G Protein Signaling-2) in the Placenta Is Associated With Human Preeclampsia and Sufficient to Cause Features of the Disorder in Mice.
Katherine J Perschbacher, Guorui Deng, Jeremy A Sandgren, John W Walsh, Phillip C Witcher, Julien A Sebag

Hypertension· February 2020

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The GPCR accessory protein MRAP2 regulates both biased signaling and constitutive activity of the ghrelin receptor GHSR1a.
Alix A J Rouault, Luciana K Rosselli-Murai, Ciria C Hernandez, Luis E Gimenez, Gregory G Tall, Julien A Sebag

Sci Signal· January 2020

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Regions of MRAP2 required for the inhibition of orexin and prokineticin receptor signaling.
Alix A J Rouault, Abigail A Lee, Julien A Sebag

Biochim Biophys Acta Mol Cell Res· December 2017

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Melanocortin Receptor Accessory Proteins (MRAPs): Functions in the melanocortin system and beyond.
Alix A J Rouault, Dinesh K Srinivasan, Terry C Yin, Abigail A Lee, Julien A Sebag

Biochim Biophys Acta Mol Basis Dis· October 2017

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MRAP2 regulates ghrelin receptor signaling and hunger sensing.
Dollada Srisai, Terry C Yin, Abigail A Lee, Alix A J Rouault, Nicole A Pearson, Julien A Sebag

Nat Commun· September 2017

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The Melanocortin Receptor Accessory Protein 2 promotes food intake through inhibition of the Prokineticin Receptor-1.
Anna L Chaly, Dollada Srisai, Ellen E Gardner, Julien A Sebag

Elife· February 2016

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G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons.
Masoud Ghamari-Langroudi, Gregory J Digby, Julien A Sebag, Glenn L Millhauser, Rafael Palomino

Nature· April 2015

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Developmental control of the melanocortin-4 receptor by MRAP2 proteins in zebrafish.
Julien A Sebag, Chao Zhang, Patricia M Hinkle, Amanda M Bradshaw, Roger D Cone

Science· July 2013

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[G-protein-coupled receptors targeting: the allosteric approach].
Julien A Sebag, Jacques Pantel

Med Sci (Paris)· October 2012

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Functional expression of frog and rainbow trout melanocortin 2 receptors using heterologous MRAP1s.
Liang Liang, Julien A Sebag, Lauren Eagelston, Madhavika N Serasinghe, Kristopher Veo

Gen Comp Endocrinol· October 2011

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Physiological roles of the melanocortin MC₃ receptor.
Benjamin J Renquist, Rachel N Lippert, Julien A Sebag, Kate L J Ellacott, Roger D Cone

Eur J Pharmacol· June 2011

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Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein.
Patricia M Hinkle, Madhavika N Serasinghe, Andrea Jakabowski, Julien A Sebag, Krista R Wilson

Eur J Pharmacol· June 2011

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Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
Jacques Pantel, Savannah Y Williams, Dehui Mi, Julien Sebag, Jackie D Corbin

Eur J Pharmacol· June 2011

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Regulation of G protein-coupled receptor signaling: specific dominant-negative effects of melanocortin 2 receptor accessory protein 2.
Julien A Sebag, Patricia M Hinkle

Sci Signal· April 2010

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Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.
Julien A Sebag, Patricia M Hinkle

J Biol Chem· August 2009

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Structure and function of the melanocortin2 receptor accessory protein (MRAP).
Patricia M Hinkle, Julien A Sebag

Mol Cell Endocrinol· March 2009

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