Publications by authors named "Kar Seng Sim"

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Direct inference and control of genetic population structure from RNA sequencing data.
Muhamad Fachrul, Abhilasha Karkey, Mila Shakya, Louise M Judd, Taylor Harshegyi, Kar Seng Sim

Commun Biol· August 2023

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A five-safes approach to a secure and scalable genomics data repository.
Chih Chuan Shih, Jieqi Chen, Ai Shan Lee, Nicolas Bertin, Maxime Hebrard, Kar Seng Sim, Xueling Sim

iScience· April 2023

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Cross-Ancestry Genome-Wide Association Study Defines the Extended CYP2D6 Locus as the Principal Genetic Determinant of Endoxifen Plasma Concentrations.
Chiea Chuen Khor, Stefan Winter, Natalia Sutiman, Thomas E Mürdter, Sylvia Chen, Kar Seng Sim, Yoon Sim Yap

Clin Pharmacol Ther· March 2023

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Low frequency variants associated with leukocyte telomere length in the Singapore Chinese population.
Xuling Chang, Resham L Gurung, Ling Wang, Aizhen Jin, Zheng Li, Kar Seng Sim

Commun Biol· May 2021

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Association of Rare CYP39A1 Variants With Exfoliation Syndrome Involving the Anterior Chamber of the Eye.

JAMA· February 2021

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Association of Genetic Variants With Primary Open-Angle Glaucoma Among Individuals With African Ancestry.

JAMA· November 2019

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Loci for human leukocyte telomere length in the Singaporean Chinese population and trans-ethnic genetic studies.
Rajkumar Dorajoo, Xuling Chang, Resham Lal Gurung, Zheng Li, Ling Wang, Kar Seng Sim

Nat Commun· June 2019

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Genome-Wide Analysis of Protein-Coding Variants in Leprosy.
Hong Liu, Zhenzhen Wang, Yi Li, Gongqi Yu, Xi'an Fu, Kar Seng Sim

J Invest Dermatol· December 2017

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Genetic association study of exfoliation syndrome identifies a protective rare variant at LOXL1 and five new susceptibility loci.
Tin Aung, Mineo Ozaki, Mei Chin Lee, Ursula Schlötzer-Schrehardt, Gudmar Thorleifsson, Nassim Khatibi, Ifeoma Asimadu, Leyla Ali Aljasim, Kar Seng Sim

Nat Genet· July 2017

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Natural resistance to Meningococcal Disease related to CFH loci: Meta-analysis of genome-wide association studies.
Federico Martinón-Torres, Eileen Png, Chiea Chuen Khor, Sonia Davila, Victoria J Wright, Kar Seng Sim, Simon Nadel

Sci Rep· November 2016

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Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study.
Zheng Li, Yi Xia, Li-Na Feng, Jie-Rong Chen, Hong-Min Li, Kar Seng Sim

Lancet Oncol· September 2016

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A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy.
Lulin Huang, Houbin Zhang, Ching-Yu Cheng, Feng Wen, Pancy O S Tam, Kar-Seng Sim

Nat Genet· June 2016

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Genome-wide association study identifies five new susceptibility loci for primary angle closure glaucoma.
Chiea Chuen Khor, Tan Do, Hongyan Jia, Masakazu Nakano, Ronnie George, Leyla A Aljasim, Kar Seng Sim

Nat Genet· May 2016

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Corrigendum: a common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Tin Aung, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, Kar Seng Sim, Leyla Al-Jasim, Simon W M John

Nat Genet· June 2015

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A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome.
Tin Aung, Mineo Ozaki, Takanori Mizoguchi, R Rand Allingham, Zheng Li, Kar Seng Sim, Leyla Al-Jasim, Simon W M John

Nat Genet· April 2015

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Meta-analysis of Genome-Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology.
Henriët Springelkamp, Aniket Mishra, Pirro G Hysi, Puya Gharahkhani, René Höhn, Kar-Seng Sim

Genet Epidemiol· March 2015

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Corrigendum: New loci and coding variants confer risk for age-related macular degeneration in East Asians.
Ching-Yu Cheng, Kenji Yamashiro, Li Jia Chen, Jeeyun Ahn, Lulin Huang, Kar Seng Sim

Nat Commun· March 2015

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New loci and coding variants confer risk for age-related macular degeneration in East Asians.
Ching-Yu Cheng, Kenji Yamashiro, Li Jia Chen, Jeeyun Ahn, Lulin Huang, Kar Seng Sim

Nat Commun· January 2015

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Variation at HLA-DRB1 is associated with resistance to enteric fever.
Sarah J Dunstan, Nguyen Thi Hue, Buhm Han, Zheng Li, Trinh Thi Bich Tram, Kar Seng Sim, Cameron P Simmons

Nat Genet· December 2014

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Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
Henriët Springelkamp, René Höhn, Aniket Mishra, Pirro G Hysi, Chiea-Chuen Khor, Kar-Seng Sim

Nat Commun· September 2014

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Deep whole-genome sequencing of 100 southeast Asian Malays.
Lai-Ping Wong, Rick Twee-Hee Ong, Wan-Ting Poh, Xuanyao Liu, Peng Chen, Kar-Seng Sim, Ngak-Leng Sim

Am J Hum Genet· January 2013

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Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.
Eranga N Vithana, Chiea-Chuen Khor, Chunyan Qiao, Monisha E Nongpiur, Ronnie George, Kar Seng Sim, Xueling Sim, Cameron P Simmons

Nat Genet· October 2012

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Natural positive selection and north-south genetic diversity in East Asia.
Chen Suo, Haiyan Xu, Chiea-Chuen Khor, Rick Th Ong, Xueling Sim, Kar-Seng Sim

Eur J Hum Genet· January 2012

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A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.
Xue-Qing Yu, Ming Li, Hong Zhang, Hui-Qi Low, Xin Wei, Kar-Seng Sim

Nat Genet· December 2011

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Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
Chiea Chuen Khor, Sonia Davila, Willemijn B Breunis, Yi-Ching Lee, Chisato Shimizu, Kar Seng Sim

Nat Genet· November 2011

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