Publications by authors named "Kathy Lyons"

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Making sense of pediatric death: An exploratory qualitative study of emotion management strategies applied by the pediatric intensive care unit interprofessional team.
Lisa Albrecht, Molly J Ryan, Eva Ta, Jennifer R Foster, Laura Buckley, Kathy Lyons

Palliat Care Soc Pract· November 2025

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Candida auris outbreak at a tertiary care hospital during the COVID-19 pandemic.
Lana Dbeibo, Cole Beeler, Lauren Clark, Megan Zondor, Catherine Sartino, Kathy Lyons

Am J Infect Control· August 2024

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Co-production of the quality of patient-centered outcomes research partnerships instrument for people with mental health conditions.
Karen L Fortuna, Amanda Myers, Jessica Brooks, Caroline Collins-Pisano, Skyla Marceau, Kathy Lyons

Patient Exp J· January 2021

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Strategies for the successful implementation of disinfecting port protectors to reduce CLABSI in a large tertiary care teaching hospital.
Cole Beeler, Denise Kerley, Carmen Davis, Dana Hazen, William Snyderman, Kathy Lyons

Am J Infect Control· December 2019

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Lead optimization toward proof-of-concept tools for Huntington's disease within a 4-(1H-pyrazol-4-yl)pyrimidine class of pan-JNK inhibitors.
John Wityak, Kevin F McGee, Michael P Conlon, Ren Hua Song, Bryan C Duffy, Kathy Lyons

J Med Chem· April 2015

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Development of a series of aryl pyrimidine kynurenine monooxygenase inhibitors as potential therapeutic agents for the treatment of Huntington's disease.
Leticia M Toledo-Sherman, Michael E Prime, Ladislav Mrzljak, Maria G Beconi, Alan Beresford, Kathy Lyons

J Med Chem· February 2015

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Assessment of chloroquine treatment for modulating autophagy flux in brain of WT and HD mice.
Petr Vodicka, Junghyun Lim, Dana T Williams, Kimberly B Kegel, Kathryn Chase, Kathy Lyons

J Huntingtons Dis· September 2014

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.
Tesfaye Biftu, Ranabir Sinha-Roy, Ping Chen, Xiaoxia Qian, Dennis Feng, Kathy Lyons

J Med Chem· April 2014

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Design, synthesis, and biological evaluation of potent and selective class IIa histone deacetylase (HDAC) inhibitors as a potential therapy for Huntington's disease.
Roland W Bürli, Christopher A Luckhurst, Omar Aziz, Kim L Matthews, Dawn Yates, Kathy A Lyons

J Med Chem· December 2013

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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Tesfaye Biftu, Xiaoxia Qian, Ping Chen, Dennis Feng, Giovanna Scapin, Kathy Lyons, Kathy Lyons

Bioorg Med Chem Lett· October 2013

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The design and synthesis of potent, selective benzodiazepine sulfonamide bombesin receptor subtype 3 (BRS-3) agonists with an increased barrier of atropisomerization.
Harry R Chobanian, Yan Guo, Ping Liu, Thomas J Lanza, Marc Chioda, Kathy Lyons

Bioorg Med Chem· May 2012

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Discovery of MK-7725, A Potent, Selective Bombesin Receptor Subtype-3 Agonist for the Treatment of Obesity.
Harry R Chobanian, Yan Guo, Ping Liu, Marc Chioda, Thomas J Lanza, Kathy Lyons

ACS Med Chem Lett· March 2012

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Discovery of benzodiazepine sulfonamide-based bombesin receptor subtype 3 agonists and their unusual chirality.
Ping Liu, Thomas J Lanza, Marc Chioda, Carrie Jones, Harry R Chobanian, Kathy Lyons

ACS Med Chem Lett· December 2011

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Substituted phenyl triazoles as selective inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1.
Wanying Sun, Milana Maletic, Steven S Mundt, Kashmira Shah, Hratch Zokian, Kathy Lyons

Bioorg Med Chem Lett· April 2011

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Bicyclo[2.2.2]octyltriazole inhibitors of 11β-hydoxysteroid dehydrogenase type 1. Pharmacological agents for the treatment of metabolic syndrome.
Milana Maletic, Aaron Leeman, Michael Szymonifka, Steven S Mundt, Hratch J Zokian, Kathy Lyons

Bioorg Med Chem Lett· April 2011

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Antiobesity effect of MK-5046, a novel bombesin receptor subtype-3 agonist.
Xiao-Ming Guan, Joseph M Metzger, Liming Yang, Kate A Raustad, Sheng-Ping Wang, Kathy A Lyons

J Pharmacol Exp Ther· February 2011

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Substituted biaryl pyrazoles as sodium channel blockers.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Brett Taylor, Michael H Fisher, Kathy Lyons

Bioorg Med Chem Lett· September 2010

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Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers.
Sriram Tyagarajan, Prasun K Chakravarty, Bishan Zhou, Michael H Fisher, Mathew J Wyvratt, Kathy Lyons

Bioorg Med Chem Lett· September 2010

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CCR5 blockade modulates inflammation and alloimmunity in primates.
Carsten Schröder, Richard N Pierson, Bao-Ngoc H Nguyen, Douglas W Kawka, Laurence B Peterson, Kathy Lyons

J Immunol· August 2007

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Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
Tesfaye Biftu, Giovanna Scapin, Suresh Singh, Dennis Feng, Joe W Becker, Kathy Lyons

Bioorg Med Chem Lett· June 2007

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Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes.
Gui-Bai Liang, Xiaoxia Qian, Dennis Feng, Tesfaye Biftu, George Eiermann, Kathy Lyons

Bioorg Med Chem Lett· April 2007

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(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Tesfaye Biftu, Dennis Feng, Xiaoxia Qian, Gui-Bai Liang, Gerard Kieczykowski, Kathy Lyons

Bioorg Med Chem Lett· January 2007

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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 2: Discovery of potent, selective, and orally bioavailable compounds.
Dong-Ming Shen, Min Shu, Christopher A Willoughby, Shrenik Shah, Christopher L Lynch, Kathy Lyons

Bioorg Med Chem Lett· February 2004

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Antagonists of human CCR5 receptor containing 4-(pyrazolyl)piperidine side chains. Part 3: SAR studies on the benzylpyrazole segment.
Min Shu, Jennifer L Loebach, Kerry A Parker, Sander G Mills, Kevin T Chapman, Kathy Lyons

Bioorg Med Chem Lett· February 2004

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Use of a small molecule CCR5 inhibitor in macaques to treat simian immunodeficiency virus infection or prevent simian-human immunodeficiency virus infection.
Ronald S Veazey, Per Johan Klasse, Thomas J Ketas, Jacqueline D Reeves, Michael Piatak, Kathy Lyons

J Exp Med· November 2003

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