Publications by authors named "George Eiermann"

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A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice.
Joel P Berger, Ranabir SinhaRoy, Alessandro Pocai, Theresa M Kelly, Giovanna Scapin, George J Eiermann

Endocrinol Diabetes Metab· January 2018

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Systemic pan-AMPK activator MK-8722 improves glucose homeostasis but induces cardiac hypertrophy.
Robert W Myers, Hong-Ping Guan, Juliann Ehrhart, Aleksandr Petrov, Srinivasa Prahalada, George Eiermann

Science· August 2017

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Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus.
Jiayi Xu, Songnian Lin, Robert W Myers, George Addona, Joel P Berger, George J Eiermann

Bioorg Med Chem Lett· May 2017

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Discovery of orally active hepatoselective glucokinase activators for treatment of Type II Diabetes Mellitus.
Jiayi Xu, Songnian Lin, Robert W Myers, Maria E Trujillo, Michele J Pachanski, George J Eiermann

Bioorg Med Chem Lett· May 2017

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Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.
Sheng-Ping Wang, Dan Zhou, Zuliang Yao, Santhosh Satapati, Ying Chen, George J Eiermann

Am J Physiol Endocrinol Metab· December 2016

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Discovery and Optimization of a Novel Triazole Series of GPR142 Agonists for the Treatment of Type 2 Diabetes.
Liangqin Guo, Dann L Parker, Yi Zang, Ramzi F Sweis, Weiguo Liu, George J Eiermann

ACS Med Chem Lett· December 2016

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The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Jason M Cox, Hong D Chu, Jeffrey T Kuethe, Ying-Duo Gao, Giovanna Scapin, George Eiermann

Bioorg Med Chem Lett· June 2016

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.
Shuwen He, Peter H Dobbelaar, Liangqin Guo, Zhixiong Ye, Jian Liu, George J Eiermann

Bioorg Med Chem Lett· March 2016

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Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
Ping Chen, Dennis Feng, Xiaoxia Qian, James Apgar, Robert Wilkening, George Eiermann

Bioorg Med Chem Lett· December 2015

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.
Shrenik K Shah, Shuwen He, Liangqin Guo, Quang Truong, Hongbo Qi, George J Eiermann

ACS Med Chem Lett· May 2015

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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.
Shuwen He, Zhong Lai, Zhixiong Ye, Peter H Dobbelaar, Shrenik K Shah, George J Eiermann

ACS Med Chem Lett· July 2014

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Diamine Derivatives as Novel Small-Molecule, Potent, and Subtype-Selective Somatostatin SST3 Receptor Agonists.
Derun Li, Zhicai Wu, Yang Yu, Richard G Ball, Liangqin Guo, George J Eiermann

ACS Med Chem Lett· June 2014

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Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents.
Jonathan W Day, Vasily Gelfanov, David Smiley, Paul E Carrington, George Eiermann

Biopolymers· April 2014

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Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes.
Tesfaye Biftu, Ranabir Sinha-Roy, Ping Chen, Xiaoxia Qian, Dennis Feng, George Eiermann

J Med Chem· April 2014

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A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity.
Elisabetta Bianchi, Paul E Carrington, Paolo Ingallinella, Marco Finotto, Alessia Santoprete, George Eiermann

Bioorg Med Chem· November 2013

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Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected].
Tesfaye Biftu, Xiaoxia Qian, Ping Chen, Dennis Feng, Giovanna Scapin, George Eiermann

Bioorg Med Chem Lett· October 2013

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The role of voltage-gated potassium channels Kv2.1 and Kv2.2 in the regulation of insulin and somatostatin release from pancreatic islets.
Xiaoyan Nina Li, James Herrington, Aleksandr Petrov, Lan Ge, George Eiermann

J Pharmacol Exp Ther· February 2013

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Differential effects of oxyntomodulin and GLP-1 on glucose metabolism.
Xiaobing Du, Jennifer R Kosinski, Julie Lao, Xiaolan Shen, Aleksandr Petrov, George J Eiermann

Am J Physiol Endocrinol Metab· July 2012

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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.
Shuwen He, Zhixiong Ye, Quang Truong, Shrenik Shah, Wu Du, George J Eiermann

ACS Med Chem Lett· June 2012

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Stimulation of Glucose-Dependent Insulin Secretion by a Potent, Selective sst3 Antagonist.
Alexander Pasternak, Zhe Feng, Reynalda de Jesus, Zhixiong Ye, Shuwen He, George J Eiermann

ACS Med Chem Lett· April 2012

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Plasma lipid profiling across species for the identification of optimal animal models of human dyslipidemia.
Wu Yin, Ester Carballo-Jane, David G McLaren, Vivienne H Mendoza, Karen Gagen, George J Eiermann

J Lipid Res· January 2012

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3-Substituted 3-(4-aryloxyaryl)-propanoic acids as GPR40 agonists.
Shawn P Walsh, Alexandra Severino, Changyou Zhou, Jiafang He, Gui-Bai Liang, George J Eiermann

Bioorg Med Chem Lett· June 2011

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Discovery of 5-aryloxy-2,4-thiazolidinediones as potent GPR40 agonists.
Changyou Zhou, Cheng Tang, Eric Chang, Min Ge, Songnian Lin, George J Eiermann

Bioorg Med Chem Lett· February 2010

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Inhibition of DPP-4 with sitagliptin improves glycemic control and restores islet cell mass and function in a rodent model of type 2 diabetes.
James Mu, Aleksandr Petrov, George J Eiermann, John Woods, Yun-Ping Zhou

Eur J Pharmacol· November 2009

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Glucagon-like peptide 1/glucagon receptor dual agonism reverses obesity in mice.
Alessandro Pocai, Paul E Carrington, Jennifer R Adams, Michael Wright, George Eiermann

Diabetes· October 2009

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