Publications by authors named "Keith Ansell"

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Evaluating the druggability of TrmD, a potential antibacterial target, through design and microbiological profiling of a series of potent TrmD inhibitors.
Andrew J Wilkinson, Nicola Ooi, Jonathan Finlayson, Victoria E Lee, David Lyth, Keith Ansell

Bioorg Med Chem Lett· June 2023

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Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Jonathan M Large, Kristian Birchall, Nathalie S Bouloc, Andy T Merritt, Ela Smiljanic-Hurley, Keith H Ansell

Bioorg Med Chem Lett· October 2019

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Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Jonathan M Large, Kristian Birchall, Nathalie S Bouloc, Andy T Merritt, Ela Smiljanic-Hurley, Keith H Ansell

Bioorg Med Chem Lett· February 2019

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Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Denise J Tsagris, Kristian Birchall, Nathalie Bouloc, Jonathan M Large, Andy Merritt, Keith H Ansell

Bioorg Med Chem Lett· October 2018

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A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
David A Baker, Lindsay B Stewart, Jonathan M Large, Paul W Bowyer, Keith H Ansell

Nat Commun· September 2017

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Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development.
Judith L Green, Robert W Moon, David Whalley, Paul W Bowyer, Claire Wallace, Keith H Ansell

Antimicrob Agents Chemother· December 2015

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Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
Keith H Ansell, Hayley M Jones, David Whalley, Alisdair Hearn, Debra L Taylor

Antimicrob Agents Chemother· October 2014

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Optimization of an imidazopyridazine series of inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Timothy M Chapman, Simon A Osborne, Claire Wallace, Kristian Birchall, Nathalie Bouloc, Keith H Ansell

J Med Chem· April 2014

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Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Jonathan M Large, Simon A Osborne, Ela Smiljanic-Hurley, Keith H Ansell, Hayley M Jones

Bioorg Med Chem Lett· November 2013

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Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Timothy M Chapman, Simon A Osborne, Nathalie Bouloc, Jonathan M Large, Claire Wallace, Keith H Ansell

Bioorg Med Chem Lett· May 2013

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Discovery of Plasmodium vivax N-myristoyltransferase inhibitors: screening, synthesis, and structural characterization of their binding mode.
Victor Goncalves, James A Brannigan, David Whalley, Keith H Ansell, Barbara Saxty

J Med Chem· April 2012

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Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
Olivier A Pierrat, Kvido Strisovsky, Yonka Christova, Jonathan Large, Keith Ansell

ACS Chem Biol· April 2011

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Synthesis and in vitro evaluation of imidazopyridazines as novel inhibitors of the malarial kinase PfPK7.
Nathalie Bouloc, Jonathan M Large, Ela Smiljanic, David Whalley, Keith H Ansell

Bioorg Med Chem Lett· October 2008

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Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes.
Sharon Yeoh, Rebecca A O'Donnell, Konstantinos Koussis, Anton R Dluzewski, Keith H Ansell

Cell· December 2007

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Inhibition of papillomavirus protein function in cervical cancer cells by intrabody targeting.
Heather Griffin, Robert Elston, Deborah Jackson, Keith Ansell, Michael Coleman

J Mol Biol· January 2006

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