Publications by authors named "Jonathan Large"

Claim this Profile
D
Design and Synthesis of Pyrazoline Inhibitors of SARS-CoV‑2 NSP14.
Elliott B Smyth, João P Pisco, Kristian Birchall, Nicole S Upfold, Arvind H Patel, Jonathan M Large

ACS Med Chem Lett· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
X
XAT-Catalysis for Intramolecular Biaryl Synthesis.
Thomas Sephton, Jonathan M Large, Louise S Natrajan, Sam Butterworth, Michael F Greaney

Angew Chem Int Ed Engl· August 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeted protein degradation in CNS disorders: a promising route to novel therapeutics?
Sandra Kuemper, Andrew G Cairns, Kristian Birchall, Zhi Yao, Jonathan M Large

Front Mol Neurosci· April 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
Aryne-Enabled C-N Arylation of Anilines.
Thomas Sephton, Anastasios Charitou, Cristina Trujillo, Jonathan M Large, Sam Butterworth

Angew Chem Int Ed Engl· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Synthesis of Functionalized Pyrrolidinone Scaffolds via Smiles-Truce Cascade.
Thomas Sephton, Jonathan M Large, Sam Butterworth, Michael F Greaney

Org Lett· September 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Diarylamine Synthesis via Desulfinylative Smiles Rearrangement.
Thomas Sephton, Jonathan M Large, Sam Butterworth, Michael F Greaney

Org Lett· February 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A "Target Class" Screen to Identify Activators of Two-Pore Domain Potassium (K2P) Channels.
David McCoull, Emma Ococks, Jonathan M Large, David C Tickle, Alistair Mathie

SLAS Discov· March 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Targeting the Malaria Parasite cGMP-Dependent Protein Kinase to Develop New Drugs.
David A Baker, Alexios N Matralis, Simon A Osborne, Jonathan M Large, Maria Penzo

Front Microbiol· December 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2.
Paul D Wright, David McCoull, Yvonne Walsh, Jonathan M Large, Barbara W Hadrys

Biochem Biophys Res Commun· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent bicyclic inhibitors of malarial cGMP-dependent protein kinase: approaches to combining improvements in cell potency, selectivity and structural novelty.
Jonathan M Large, Kristian Birchall, Nathalie S Bouloc, Andy T Merritt, Ela Smiljanic-Hurley

Bioorg Med Chem Lett· October 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Developing an Antibody-Drug Conjugate Approach to Selective Inhibition of an Extracellular Protein.
Elizabeth A Love, Afrah Sattikar, Hannah Cook, Kevin Gillen, Jonathan M Large

Chembiochem· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Potent inhibitors of malarial P. Falciparum protein kinase G: Improving the cell activity of a series of imidazopyridines.
Jonathan M Large, Kristian Birchall, Nathalie S Bouloc, Andy T Merritt, Ela Smiljanic-Hurley

Bioorg Med Chem Lett· February 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG).
Denise J Tsagris, Kristian Birchall, Nathalie Bouloc, Jonathan M Large, Andy Merritt

Bioorg Med Chem Lett· October 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Terbinafine is a novel and selective activator of the two-pore domain potassium channel TASK3.
Paul D Wright, Emma L Veale, David McCoull, David C Tickle, Jonathan M Large

Biochem Biophys Res Commun· November 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
David A Baker, Lindsay B Stewart, Jonathan M Large, Paul W Bowyer, Keith H Ansell

Nat Commun· September 2017

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
B
Biochemical and antiparasitic properties of inhibitors of the Plasmodium falciparum calcium-dependent protein kinase PfCDPK1.
Keith H Ansell, Hayley M Jones, David Whalley, Alisdair Hearn, Debra L Taylor, Jonathan Large

Antimicrob Agents Chemother· October 2014

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues.
Jonathan M Large, Simon A Osborne, Ela Smiljanic-Hurley, Keith H Ansell, Hayley M Jones

Bioorg Med Chem Lett· November 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.
Rachel White, Barbara Saxty, Jonathan Large, Catherine A Kettleborough, Andrew P Jackson

J Biomol Screen· June 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure of rhomboid protease in complex with β-lactam inhibitors defines the S2' cavity.
Kutti R Vinothkumar, Olivier A Pierrat, Jonathan M Large, Matthew Freeman

Structure· June 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1).
Timothy M Chapman, Simon A Osborne, Nathalie Bouloc, Jonathan M Large, Claire Wallace

Bioorg Med Chem Lett· May 2013

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
M
Monocyclic β-lactams are selective, mechanism-based inhibitors of rhomboid intramembrane proteases.
Olivier A Pierrat, Kvido Strisovsky, Yonka Christova, Jonathan Large, Keith Ansell

ACS Chem Biol· April 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
Preparation and evaluation of trisubstituted pyrimidines as phosphatidylinositol 3-kinase inhibitors. 3-Hydroxyphenol analogues and bioisosteric replacements.
Jonathan M Large, Jane E Torr, Florence I Raynaud, Paul A Clarke, Angela Hayes

Bioorg Med Chem· January 2011

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Structure-based design of imidazo[1,2-a]pyrazine derivatives as selective inhibitors of Aurora-A kinase in cells.
Nathalie Bouloc, Jonathan M Large, Magda Kosmopoulou, Chongbo Sun, Amir Faisal

Bioorg Med Chem Lett· October 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
I
Imidazo[4,5-b]pyridine derivatives as inhibitors of Aurora kinases: lead optimization studies toward the identification of an orally bioavailable preclinical development candidate.
Vassilios Bavetsias, Jonathan M Large, Chongbo Sun, Nathalie Bouloc, Magda Kosmopoulou

J Med Chem· July 2010

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Design and combinatorial synthesis of a library of methylenesulfonamides and related compounds as potential kinase inhibitors.
Jane E Torr, Jonathan M Large, Edward McDonald

Comb Chem High Throughput Screen· March 2009

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis