Publications by authors named "Keith R Fox"

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Synthesis, SAR, and biophysical mechanism of action of cyclopropabenzindole-pyridinobenzodiazepine (CBI-PDD) guanine-adenine DNA cross-linking agents.
George Procopiou, Paul J M Jackson, Daniella di Mascio, Jennifer L Auer, Paolo Andriollo, Keith R Fox

Eur J Med Chem· January 2026

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Synthesis and Evaluation of DNA Cross-linkers by Click Chemistry-Mediated Heterodimerization of Nor-Tomaymycins.
Julia Friederich, Katharina Rox, Hazel L S Fuchs, Md Mahbub Hasan, Patrick Raunft, Keith R Fox

Chemistry· September 2025

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A novel DNA sequence-selective, guanine mono-alkylating ADC payload suitable for solid tumour treatment.
Paolo Andriollo, Daniella di Mascio, Paul J M Jackson, Md Mahbub Hasan, Ilona Pysz-Hosey, Keith R Fox

RSC Med Chem· July 2025

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The Novel DNA Binding Mechanism of Ridinilazole, a Precision Antibiotic.
Clive S Mason, Tim Avis, Chenlin Hu, Nabeetha Nagalingam, Manikhandan Mudaliar, Keith R Fox

Antimicrob Agents Chemother· May 2023

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A simplified and easy-to-use HIP HOP assay provides insights into chalcone antifungal mechanisms of action.
Thomas A K Prescott, Laura Anaissi-Afonso, Keith R Fox, Anthony Maxwell, Barry Panaretou

FEBS Lett· December 2022

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DNA sequence-selective G-A cross-linking ADC payloads for use in solid tumour therapies.
George Procopiou, Paul J M Jackson, Daniella di Mascio, Jennifer L Auer, Chris Pepper, Keith R Fox

Commun Biol· July 2022

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Melting temperature measurement and mesoscopic evaluation of single, double and triple DNA mismatches.
Luciana M Oliveira, Adam S Long, Tom Brown, Keith R Fox, Gerald Weber

Chem Sci· July 2020

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Synthesis and Biological Evaluation of a Novel C8-Pyrrolobenzodiazepine (PBD) Adenosine Conjugate. A Study on the Role of the PBD Ring in the Biological Activity of PBD-Conjugates.
Lindsay Ferguson, Sanjib Bhakta, Keith R Fox, Geoff Wells, Federico Brucoli

Molecules· March 2020

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Stability of the different arms of a DNA tetrahedron and its interaction with a minor groove ligand.
Michael L J Carter, David A Rusling, Steven Gurr, Tom Brown, Keith R Fox

Biophys Chem· January 2020

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DNA Structural Changes Induced by Intermolecular Triple Helix Formation.
Ibrahim Sayoh, David A Rusling, Tom Brown, Keith R Fox

ACS Omega· January 2020

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Editorial: Preprints, citations and Nucleic Acids Research.
Barry L Stoddard, Keith R Fox

Nucleic Acids Res· January 2019

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Editorial: Nucleic Acids Research and Nucleic Acid Therapeutics.
Barry L Stoddard, Anastasia Khvorova, David R Corey, William S Dynan, Keith R Fox

Nucleic Acids Res· February 2018

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Structural basis of DNA duplex distortion induced by thiazole-containing hairpin polyamides.
Giacomo Padroni, John A Parkinson, Keith R Fox, Glenn A Burley

Nucleic Acids Res· January 2018

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The effects of DNA supercoiling on G-quadruplex formation.
Doreen A T Sekibo, Keith R Fox

Nucleic Acids Res· December 2017

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Sequence-selective binding of C8-conjugated pyrrolobenzodiazepines (PBDs) to DNA.
Mohammad A Basher, Khondaker Miraz Rahman, Paul J M Jackson, David E Thurston, Keith R Fox

Biophys Chem· November 2017

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DNA sequence-selective C8-linked pyrrolobenzodiazepine-heterocyclic polyamide conjugates show anti-tubercular-specific activities.
Federico Brucoli, Juan D Guzman, Mohammad A Basher, Dimitrios Evangelopoulos, Eleanor McMahon, Keith R Fox

J Antibiot (Tokyo)· December 2016

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Stabilisation of self-assembled DNA crystals by triplex-directed photo-cross-linking.
Hatem O Abdallah, Yoel P Ohayon, Arun Richard Chandrasekaran, Ruojie Sha, Keith R Fox

Chem Commun (Camb)· June 2016

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The effect of sequence context on the activity of cytosine DNA glycosylases.
Scott T Kimber, Tom Brown, Keith R Fox

Mol Biosyst· December 2015

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Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity.
Michael J Stephenson, Lesley A Howell, Maria A O'Connell, Keith R Fox, Claire Adcock

J Org Chem· October 2015

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Synthesis, anti-mycobacterial activity and DNA sequence-selectivity of a library of biaryl-motifs containing polyamides.
Federico Brucoli, Juan D Guzman, Arundhati Maitra, Colin H James, Keith R Fox

Bioorg Med Chem· July 2015

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A mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosine.
Scott T Kimber, Tom Brown, Keith R Fox

PLoS One· June 2015

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Breakthrough articles: putting science first.
David R Corey, Jo Ann Wise, Keith R Fox, Barry L Stoddard

Nucleic Acids Res· October 2014

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Sequence-specific recognition of DNA nanostructures.
David A Rusling, Keith R Fox

Methods· May 2014

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Functionalizing designer DNA crystals with a triple-helical veneer.
David A Rusling, Arun Richard Chandrasekaran, Yoel P Ohayon, Tom Brown, Keith R Fox

Angew Chem Int Ed Engl· April 2014

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Thioester Bonds of Thiocoraline Can Be Replaced with NMe-Amide Bridges without Affecting Its DNA-Binding Properties.
Rubí Zamudio-Vázquez, Fernando Albericio, Judit Tulla-Puche, Keith R Fox

ACS Med Chem Lett· January 2014

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