Publications by authors named "Kevin Coe"

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Strategies to Improve Pharmacokinetics of Hepatic Uptake Transporter Substrates.
Sarah M Glass, David Polidori, Kevin J Coe, Hariharan Venkatesan, Alexander S Burns

J Med Chem· July 2025

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Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis.
Olaf Kinzel, Steven D Goldberg, Maxwell D Cummings, Christian Gege, Christoph Steeneck, Kevin Coe

J Med Chem· April 2025

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Combining genome-wide association and genomic prediction to unravel the genetic architecture of carotenoid accumulation in carrot.
William R Rolling, Shelby Ellison, Kevin Coe, Massimo Iorizzo, Julie Dawson

Plant Genome· March 2025

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The Current State of Biotransformation Science - Industry Survey of In Vitro and In Vivo Practices, Clinical Translation, and Future Trends.
John P Savaryn, Kevin Coe, Matthew A Cerny, Kevin Colizza, Patricia Moliner

Pharm Res· November 2024

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Application of Covalent Binding Body Burden in the HμREL Human Hepatocyte Coculture Model for Reactivity Risk Assessment of Metabolically Low Turnover Drugs.
Jackie Shang, Kevin J Coe, Heng Keang Lim, Lu Chen, Buddha B Khatri

Chem Res Toxicol· April 2024

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Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
Holger Babbe, Thomas B Sundberg, Mark Tichenor, Mark Seierstad, Genesis Bacani, Kevin Coe

Proc Natl Acad Sci U S A· January 2024

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Population genomics identifies genetic signatures of carrot domestication and improvement and uncovers the origin of high-carotenoid orange carrots.
Kevin Coe, Hamed Bostan, William Rolling, Sarah Turner-Hissong, Alicja Macko-Podgórni

Nat Plants· October 2023

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Development of a Dihydroquinoline-Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the -Methyl-d-aspartate Receptor.
Michael P D'Erasmo, Nicholas S Akins, Peipei Ma, Yao Jing, Sharon A Swanger, Kevin Coe

ACS Chem Neurosci· September 2023

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A Phase 1 First-in-Human Pharmacokinetic and Pharmacodynamic Study of JNJ-64264681, a Covalent Inhibitor of Bruton's Tyrosine Kinase.
Jocelyn H Leu, Xin Miao, Kevin Shalayda, Kevin J Coe, Ariane Kahnt

Clin Pharmacol Drug Dev· June 2023

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Discovery of a Series of Substituted 1-((1,2,3-Triazol-4-yl)methoxy)pyrimidines as Brain Penetrants and Potent GluN2B-Selective Negative Allosteric Modulators.
Christine F Gelin, Brice Stenne, Heather Coate, Afton Hiscox, Akinola Soyode-Johnson, Kevin J Coe

J Med Chem· February 2023

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Mark S Tichenor, John J M Wiener, Navin L Rao, Genesis M Bacani, Jianmei Wei, Kevin J Coe

J Med Chem· November 2022

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Characterization of JNJ-2482272 [4-(4-Methyl-2-(4-(Trifluoromethyl)Phenyl)Thiazole-5-yl) Pyrimidine-2-Amine] As a Strong Aryl Hydrocarbon Receptor Activator in Rat and Human.
Kevin J Coe, Mark Feinstein, J William Higgins, Perry Leung, Brian P Scott

Drug Metab Dispos· August 2022

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The influence of the Or and Carotene Hydroxylase genes on carotenoid accumulation in orange carrots [Daucus carota (L.)].
Kevin M Coe, Shelby Ellison, Douglas Senalik, Julie Dawson, Philipp Simon

Theor Appl Genet· October 2021

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Discovery of a Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase with Oral Anti-Inflammatory Activity.
Mark S Tichenor, John J M Wiener, Navin L Rao, Charlotte Pooley Deckhut, J Kent Barbay, Kevin J Coe

ACS Med Chem Lett· May 2021

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Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin-1 Antagonists: Discovery of JNJ-54717793.
Cathy Préville, Pascal Bonaventure, Tatiana Koudriakova, Brian Lord, Diane Nepomuceno, Kevin J Coe

ACS Med Chem Lett· October 2020

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The Genetic Diversity of Cranberry Crop Wild Relatives, Aiton and L., in the US, with Special Emphasis on National Forests.
Lorraine Rodriguez-Bonilla, Karen A Williams, Fabian Rodríguez Bonilla, Daniel Matusinec, Andrew Maule, Kevin Coe

Plants (Basel)· October 2020

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Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
Christa C Chrovian, Akinola Soyode-Johnson, Brice Stenne, Daniel J Pippel, Jeffrey Schoellerman, Kevin J Coe

J Med Chem· September 2020

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Optimization and biological evaluation of thiazole-bis-amide inverse agonists of RORγt.
Christian Gege, Michael Albers, Olaf Kinzel, Gerald Kleymann, Thomas Schlüter, Kevin Coe

Bioorg Med Chem Lett· June 2020

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Is News Surveillance related to Cancer Knowledge in Underserved Adults? Testing Three Versions of the Cognitive Mediation Model.
Jakob D Jensen, Andy J King, Debora Perez Torres, Melinda Krakow, Kevin Coe

Journal Stud· March 2020

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1-Pyrrolo[3,2-]pyridine GluN2B-Selective Negative Allosteric Modulators.
Christa C Chrovian, Akinola Soyode-Johnson, Jessica L Wall, Jason C Rech, Jeff Schoellerman, Kevin J Coe

ACS Med Chem Lett· March 2019

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Discovery of Imidazo[1,2-]pyrazines and Pyrazolo[1,5-]pyrimidines as TARP γ-8 Selective AMPAR Negative Modulators.
Brad M Savall, Dongpei Wu, Devin M Swanson, Mark Seierstad, Nyantsz Wu, Kevin Coe

ACS Med Chem Lett· March 2019

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Carotenoid Presence Is Associated with the Gene in Domesticated Carrot.
Shelby L Ellison, Claire H Luby, Keo E Corak, Kevin M Coe, Douglas Senalik

Genetics· December 2018

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Lead Optimization of 5-Aryl Benzimidazolone- and Oxindole-Based AMPA Receptor Modulators Selective for TARP γ-8.
Suchitra Ravula, Brad M Savall, Nyantsz Wu, Brian Lord, Kevin Coe

ACS Med Chem Lett· August 2018

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A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
Christa C Chrovian, Akinola Soyode-Johnson, Alexander A Peterson, Christine F Gelin, Xiaohu Deng, Kevin J Coe

J Med Chem· January 2018

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4-Methyl-6,7-dihydro-4H-triazolo[4,5-c]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate.
Michael A Letavic, Brad M Savall, Brett D Allison, Leah Aluisio, Jose Ignacio Andres, Kevin J Coe

J Med Chem· June 2017

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