Publications by authors named "Kevin Hodgetts"

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Impairment of hippocampal long-term potentiation by soluble amyloid-β oligomers is mediated by glutamate transporter 1 expressed in neurons.
Shaomin Li, Jianlin Wang, Qianqin Guo, Yunxin Bai, Wen Liu, Kevin J Hodgetts

Neural Regen Res· March 2025

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Identification of environmental factors that promote intestinal inflammation.
Liliana M Sanmarco, Chun-Cheih Chao, Yu-Chao Wang, Jessica E Kenison, Zhaorong Li, Kevin J Hodgetts

Nature· November 2022

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Lipase regulation of cellular fatty acid homeostasis as a Parkinson's disease therapeutic strategy.
Saranna Fanning, Haley Cirka, Jennifer L Thies, Jooyoung Jeong, Sarah M Niemi, Kevin J Hodgetts

NPJ Parkinsons Dis· June 2022

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Nanotherapeutic approaches to overcome distinct drug resistance barriers in models of breast cancer.
Tanmoy Saha, Jayanta Mondal, Sachin Khiste, Hrvoje Lusic, Zhang-Wei Hu, Kevin J Hodgetts

Nanophotonics· September 2021

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Barcoded viral tracing of single-cell interactions in central nervous system inflammation.
Iain C Clark, Cristina Gutiérrez-Vázquez, Michael A Wheeler, Zhaorong Li, Veit Rothhammer, Kevin J Hodgetts

Science· April 2021

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A Stearoyl-Coenzyme A Desaturase Inhibitor Prevents Multiple Parkinson Disease Phenotypes in α-Synuclein Mice.
Silke Nuber, Alice Y Nam, Molly M Rajsombath, Haley Cirka, Xiaoping Hronowski, Kevin Hodgetts

Ann Neurol· January 2021

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Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy.
Anne Rietz, Kevin J Hodgetts, Hrvoje Lusic, Kevin M Quist, Erkan Y Osman

Life Sci Alliance· January 2021

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Restoring tripartite glutamatergic synapses: A potential therapy for mood and cognitive deficits in Gulf War illness.
Xueqin Wang, Zan Xu, Fangli Zhao, Kuanhung J Lin, Joshua B Foster, Kevin J Hodgetts

Neurobiol Stress· November 2020

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Enhancement of tripartite synapses as a potential therapeutic strategy for Alzheimer's disease: a preclinical study in rTg4510 mice.
Joshua B Foster, Rashelle Lashley, Fangli Zhao, Xueqin Wang, Nydia Kung, Kevin J Hodgetts

Alzheimers Res Ther· August 2019

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Pyridazine-derivatives Enhance Structural and Functional Plasticity of Tripartite Synapse Via Activation of Local Translation in Astrocytic Processes.
Joshua B Foster, Fangli Zhao, Xueqin Wang, Zan Xu, Kuanhung Lin, Kevin J Hodgetts

Neuroscience· September 2018

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Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers.
Sungwoon Choi, Alyssa N Calder, Eliza H Miller, Kierstyn P Anderson, Dawid K Fiejtek, Kevin J Hodgetts

Bioorg Med Chem Lett· December 2017

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Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
Anne Rietz, Hongxia Li, Kevin M Quist, Jonathan J Cherry, Christian L Lorson, Kevin J Hodgetts

J Med Chem· June 2017

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Small Molecules in Development for the Treatment of Spinal Muscular Atrophy.
Alyssa N Calder, Elliot J Androphy, Kevin J Hodgetts

J Med Chem· November 2016

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Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease.
Kou Takahashi, Qiongman Kong, Yuchen Lin, Nathan Stouffer, Delanie A Schulte, Kevin J Hodgetts

J Exp Med· March 2015

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Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
Kevin J Hodgetts, Ping Ge, Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck

J Med Chem· June 2011

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Pyrido[2,3-b]pyrazines, discovery of TRPV1 antagonists with reduced potential for the formation of reactive metabolites.
Kevin J Hodgetts, Charles A Blum, Timothy Caldwell, Rajagopal Bakthavatchalam, Xiaozhang Zheng

Bioorg Med Chem Lett· August 2010

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Discovery of novel 6,6-heterocycles as transient receptor potential vanilloid (TRPV1) antagonists.
Charles A Blum, Timothy Caldwell, Xiaozhang Zheng, Rajagopal Bakthavatchalam, Scott Capitosti, Kevin J Hodgetts

J Med Chem· April 2010

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1-Benzylbenzimidazoles: the discovery of a novel series of bradykinin B(1) receptor antagonists.
Qin Guo, Jayaraman Chandrasekhar, David Ihle, David J Wustrow, Bertrand L Chenard, Kevin J Hodgetts

Bioorg Med Chem Lett· September 2008

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Aminoquinazolines as TRPV1 antagonists: modulation of drug-like properties through the exploration of 2-position substitution.
Charles A Blum, Xiaozhang Zheng, Harry Brielmann, Kevin J Hodgetts, Rajagopal Bakthavatchalam

Bioorg Med Chem Lett· August 2008

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2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, James E Krause, Kevin J Hodgetts

Bioorg Med Chem Lett· August 2008

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The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, Jayaraman Chandrasekhar, Kevin J Hodgetts

Bioorg Med Chem Lett· February 2008

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From arylureas to biarylamides to aminoquinazolines: discovery of a novel, potent TRPV1 antagonist.
Xiaozhang Zheng, Kevin J Hodgetts, Harry Brielmann, Alan Hutchison, Frank Burkamp

Bioorg Med Chem Lett· October 2006

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2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists.
Kevin J Hodgetts, Taeyoung Yoon, Jianhua Huang, Michael Gulianello, Andrzej Kieltyka

Bioorg Med Chem Lett· August 2003

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Synthesis of 2-aryl-oxazolo[4,5-c]quinoline-4(5H)-ones and 2-aryl-thiazolo[4,5-c]quinoline-4(5H)-ones.
Kevin J Hodgetts, Mark T Kershaw

Org Lett· August 2003

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Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.
He Zhao, Xiaoyan Zhang, Kevin Hodgetts, Andrew Thurkauf, Jack Hammer

Bioorg Med Chem Lett· February 2003

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