Publications by authors named "Robbin Brodbeck"

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P2X7 receptor-mediated release of microglial prostanoids and miRNAs correlates with reversal of neuropathic hypersensitivity in rats.
Roland Staal, Tanzilya Khayrullina, Rie Christensen, Sara Hestehave, Hua Zhou, Robbin M Brodbeck

Eur J Pain· July 2022

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Chemical biology of mGlu4 receptor activation: dogmas, challenges, strategies and opportunities.
Xinyan Huang, Elena Dale, Robbin M Brodbeck, Dario Doller

Curr Top Med Chem· June 2015

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Fused thiazolyl alkynes as potent mGlu5 receptor positive allosteric modulators.
Mathivanan Packiarajan, Michel Grenon, Samuel Zorn, Allen T Hopper, Andrew D White, Robbin M Brodbeck

Bioorg Med Chem Lett· July 2013

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Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators.
Hao Zhou, Sidney W Topiol, Michel Grenon, Hermogenes N Jimenez, Michelle A Uberti, Robbin M Brodbeck

Bioorg Med Chem Lett· March 2013

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Azetidinyl oxadiazoles as potent mGluR5 positive allosteric modulators.
Mathivanan Packiarajan, Christine G Mazza Ferreira, Sang-Phyo Hong, Andrew D White, Gamini Chandrasena, Robbin M Brodbeck

Bioorg Med Chem Lett· October 2012

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N-Aryl pyrrolidinonyl oxadiazoles as potent mGluR5 positive allosteric modulators.
Mathivanan Packiarajan, Christine G Mazza Ferreira, Sang-Phyo Hong, Andrew D White, Gamini Chandrasena, Robbin M Brodbeck

Bioorg Med Chem Lett· September 2012

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Efficacy switching SAR of mGluR5 allosteric modulators: highly potent positive and negative modulators from one chemotype.
Anette Graven Sams, Gitte Kobberøe Mikkelsen, Robbin M Brodbeck, Xiaosui Pu, Andreas Ritzén

Bioorg Med Chem Lett· June 2011

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Discovery of N-(1-ethylpropyl)-[3-methoxy-5-(2-methoxy-4-trifluoromethoxyphenyl)-6-methyl-pyrazin-2-yl]amine 59 (NGD 98-2): an orally active corticotropin releasing factor-1 (CRF-1) receptor antagonist.
Kevin J Hodgetts, Ping Ge, Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck

J Med Chem· June 2011

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Novel heterocyclic compounds as mGlu5 antagonists: WO2009015897.
Dario Doller, Guiying Li, Robbin M Brodbeck, Christian Thomsen

Expert Opin Ther Pat· March 2010

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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator.
Andreas Ritzén, Rikke Sindet, Morten Hentzer, Nannette Svendsen, Robbin M Brodbeck

Bioorg Med Chem Lett· June 2009

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Identification and characterization of NDT 9513727 [N,N-bis(1,3-benzodioxol-5-ylmethyl)-1-butyl-2,4-diphenyl-1H-imidazole-5-methanamine], a novel, orally bioavailable C5a receptor inverse agonist.
Robbin M Brodbeck, Daniel N Cortright, Andrzej P Kieltyka, Jianying Yu, Carolyn O Baltazar

J Pharmacol Exp Ther· December 2008

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2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, James E Krause

Bioorg Med Chem Lett· August 2008

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Aminopyrazine CB1 receptor inverse agonists.
David J Wustrow, George D Maynard, Jun Yuan, He Zhao, Jianmin Mao, Robbin M Brodbeck

Bioorg Med Chem Lett· June 2008

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The design, synthesis and structure-activity relationships of 1-aryl-4-aminoalkylisoquinolines: a novel series of CRF-1 receptor antagonists.
Taeyoung Yoon, Stéphane De Lombaert, Robbin Brodbeck, Michael Gulianello, Jayaraman Chandrasekhar

Bioorg Med Chem Lett· February 2008

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Leukocyte effects of C5a-receptor blockade during simulated extracorporeal circulation.
Christine S Rinder, Michael J Smith, Henry M Rinder, Daniel N Cortright, Robbin M Brodbeck

Ann Thorac Surg· January 2007

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Molecular characterization of the gerbil C5a receptor and identification of a transmembrane domain V amino acid that is crucial for small molecule antagonist interaction.
Stephen M Waters, Robbin M Brodbeck, Jeremy Steflik, Jianying Yu, Carolyn Baltazar

J Biol Chem· December 2005

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1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.
Andrew Thurkauf, Xi Chen, Suoming Zhang, Yang Gao, Andrzej Kieltyka, Robbin Brodbeck

Bioorg Med Chem Lett· September 2003

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2-Aryl-3,6-dialkyl-5-dialkylaminopyrimidin-4-ones as novel crf-1 receptor antagonists.
Kevin J Hodgetts, Taeyoung Yoon, Jianhua Huang, Michael Gulianello, Andrzej Kieltyka, Robbin Brodbeck

Bioorg Med Chem Lett· August 2003

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C5L2, a nonsignaling C5A binding protein.
Shoji Okinaga, Dubhfeasa Slattery, Alison Humbles, Zsusanna Zsengeller, Olivier Morteau, Robbin M Brodbeck

Biochemistry· August 2003

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Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.
He Zhao, Xiaoyan Zhang, Kevin Hodgetts, Andrew Thurkauf, Jack Hammer, Robbin Brodbeck

Bioorg Med Chem Lett· February 2003

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Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.
He Zhao, Andrew Thurkauf, Xiaoshu He, Kevin Hodgetts, Xiaoyan Zhang, Robbin Brodbeck

Bioorg Med Chem Lett· November 2002

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Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.
He Zhao, Xiaoshu He, Andrew Thurkauf, Diane Hoffman, Andrzej Kieltyka, Robbin Brodbeck

Bioorg Med Chem Lett· November 2002

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3-Aryl pyrazolo[4,3-d]pyrimidine derivatives: Nonpeptide CRF-1 antagonists.
Jun Yuan, Michael Gulianello, Stéphane De Lombaert, Robbin Brodbeck, Andrzej Kieltyka

Bioorg Med Chem Lett· August 2002

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