Publications by authors named "Kia Sepassi"

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Canine Mdr1 Knockout MDCK Cells Reliably Estimate Human Small Intestinal Permeability () and Fraction Absorbed ().
Kristian Beran, Seong Hee Park, An Van den Bergh, Jennifer Dressman, Eline Hermans, Kia Sepassi

Mol Pharm· October 2025

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Improved estimation of intrinsic solubility of drug-like molecules through multi-task graph transformer.
Jiaxi Zhao, Eline Hermans, Kia Sepassi, Christophe Tistaert, Christel A S Bergström

J Cheminform· October 2025

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Identification of JNJ-61803534, a RORγt Inverse Agonist for the Treatment of Psoriasis.
Olaf Kinzel, Steven D Goldberg, Maxwell D Cummings, Christian Gege, Christoph Steeneck, Kia Sepassi

J Med Chem· April 2025

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Advantages of the refined developability classification system in early discovery.
Kristian Beran, Jennifer Dressman, Eline Hermans, René Holm, Kia Sepassi

J Pharm Sci· February 2025

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Using the refined Developability Classification System (rDCS) to guide the design of oral formulations.
Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman

J Pharm Sci· December 2024

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Effect of Data Quality and Data Quantity on the Estimation of Intrinsic Solubility: Analysis Based on a Single-Source Data Set.
Jiaxi Zhao, Eline Hermans, Kia Sepassi, Christophe Tistaert, Christel A S Bergström

Mol Pharm· October 2024

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A Stratified Analysis of Supersaturation and Precipitation Effects Based on the Refined Developability Classification System (rDCS).
Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman

J Pharm Sci· September 2024

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Projection of Target Drug Particle Size in Oral Formulations Using the Refined Developability Classification System (rDCS).
Kristian Beran, Eline Hermans, René Holm, Kia Sepassi, Jennifer Dressman

Pharmaceutics· July 2023

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Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Mark S Tichenor, John J M Wiener, Navin L Rao, Genesis M Bacani, Jianmei Wei, Kia Sepassi

J Med Chem· November 2022

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Design, Synthesis, and Preclinical Evaluation of 3-Methyl-6-(5-thiophenyl)-1,3-dihydro-imidazo[4,5-]pyridin-2-ones as Selective GluN2B Negative Allosteric Modulators for the Treatment of Mood Disorders.
Christa C Chrovian, Akinola Soyode-Johnson, Brice Stenne, Daniel J Pippel, Jeffrey Schoellerman, Kia Sepassi

J Med Chem· September 2020

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A Dipolar Cycloaddition Reaction To Access 6-Methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines Enables the Discovery Synthesis and Preclinical Profiling of a P2X7 Antagonist Clinical Candidate.
Christa C Chrovian, Akinola Soyode-Johnson, Alexander A Peterson, Christine F Gelin, Xiaohu Deng, Kia Sepassi

J Med Chem· January 2018

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Identification of (R)-(2-Chloro-3-(trifluoromethyl)phenyl)(1-(5-fluoropyridin-2-yl)-4-methyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)methanone (JNJ 54166060), a Small Molecule Antagonist of the P2X7 receptor.
Devin M Swanson, Brad M Savall, Kevin J Coe, Freddy Schoetens, Tatiana Koudriakova, Kia Sepassi

J Med Chem· September 2016

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Characterization of 2-(2,6-dichloro-benzyl)-thiazolo[5,4-d]pyrimidin-7-yl]-(4-trifluoromethyl-phenyl)-amine (JNJ-39729209) as a novel TRPV1 antagonist.
Michael P Maher, Anindya Bhattacharya, Hong Ao, Nadia Swanson, Nyan-Tsz Wu, Kia Sepassi

Eur J Pharmacol· August 2011

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Pharmacological characterization of 1-(5-chloro-6-(trifluoromethoxy)-1H-benzoimidazol-2-yl)-1H-pyrazole-4-carboxylic acid (JNJ-42041935), a potent and selective hypoxia-inducible factor prolyl hydroxylase inhibitor.
Terrance D Barrett, Heather L Palomino, Theresa I Brondstetter, Kimon C Kanelakis, Xiaodong Wu, Kia Sepassi

Mol Pharmacol· June 2011

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Pre-clinical characterization of aryloxypyridine amides as histamine H3 receptor antagonists: identification of candidates for clinical development.
Michael A Letavic, Leah Aluisio, John R Atack, Pascal Bonaventure, Nicholas I Carruthers, Kia Sepassi

Bioorg Med Chem Lett· July 2010

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Formulation and in vivo evaluation of chlorpropham (CIPC) oral formulations.
Philip J Kuehl, Tim Brenner, Parijat K Jain, Kelly Karlage, Kia Sepassi

J Pharm Sci· December 2008

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Accounting for the effects of moderately increased pressure on the energetics of melting and solubility in metered dose inhalers.
Erik Mogalian, Kia Sepassi, Paul Brian Myrdal

Drug Dev Ind Pharm· September 2008

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Comparison of aqueous solubility estimation from AQUAFAC and the GSE.
Parijat Jain, Kia Sepassi, Samuel H Yalkowsky

Int J Pharm· August 2008

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Solubility prediction in octanol: A technical note.
Kia Sepassi, Samuel H Yalkowsky

AAPS PharmSciTech· March 2006

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Solubility prediction in octanol: a technical note.
Kia Sepassi, Samuel H Yalkowsky

AAPS PharmSciTech· March 2006

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