Publications by authors named "Kirk Wright"

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Multimodal small-molecule screening for human prion protein binders.
Andrew G Reidenbach, Michael F Mesleh, Dominick Casalena, Sonia M Vallabh, Jayme L Dahlin, S Kirk Wright

J Biol Chem· September 2020

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A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays.
Christian Bergsdorf, S Kirk Wright

Methods Enzymol· June 2019

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Biophysics: for HTS hit validation, chemical lead optimization, and beyond.
Christine C Genick, S Kirk Wright

Expert Opin Drug Discov· September 2017

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Allosteric Mutant IDH1 Inhibitors Reveal Mechanisms for IDH1 Mutant and Isoform Selectivity.
Xiaoling Xie, Daniel Baird, Kimberly Bowen, Vladimir Capka, Jinyun Chen, Kirk Wright

Structure· March 2017

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Toward the Validation of Maternal Embryonic Leucine Zipper Kinase: Discovery, Optimization of Highly Potent and Selective Inhibitors, and Preliminary Biology Insight.
B Barry Touré, John Giraldes, Troy Smith, Elizabeth R Sprague, Yaping Wang, Kirk Wright

J Med Chem· May 2016

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A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
Christian G Noble, Siew Pheng Lim, Rishi Arora, Fumiaki Yokokawa, Shahul Nilar, S Kirk Wright

J Biol Chem· April 2016

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Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies.
Peter S Kutchukian, Anne Mai Wassermann, Mika K Lindvall, S Kirk Wright, Johannes Ottl

J Biomol Screen· June 2015

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Isothermal chemical denaturation to determine binding affinity of small molecules to G-protein coupled receptors.
Patrick Ross, Wilhelm Weihofen, Fai Siu, Amy Xie, Hetal Katakia, S Kirk Wright

Anal Biochem· March 2015

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Identifying initiation and elongation inhibitors of dengue virus RNA polymerase in a high-throughput lead-finding campaign.
Thomas M Smith, Siew Pheng Lim, Kimberley Yue, Scott A Busby, Rishi Arora, S Kirk Wright

J Biomol Screen· January 2015

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The structure of the BIR3 domain of cIAP1 in complex with the N-terminal peptides of SMAC and caspase-9.
Raviraj Kulathila, Brian Vash, David Sage, Susan Cornell-Kennon, Kirk Wright

Acta Crystallogr D Biol Crystallogr· January 2009

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Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.
Allen A Thomas, Y Le Huerou, J De Meese, Indrani Gunawardana, Tomas Kaplan, S Kirk Wright

Bioorg Med Chem Lett· March 2008

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Prodrug thiamine analogs as inhibitors of the enzyme transketolase.
Yvan Le Huerou, Indrani Gunawardana, Allen A Thomas, Steven A Boyd, Jason de Meese, S Kirk Wright

Bioorg Med Chem Lett· January 2008

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Non-charged thiamine analogs as inhibitors of enzyme transketolase.
Allen A Thomas, J De Meese, Y Le Huerou, Steven A Boyd, Todd T Romoff, S Kirk Wright

Bioorg Med Chem Lett· January 2008

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Isotope effects on the enzymatic and nonenzymatic reactions of chorismate.
S Kirk Wright, Michael S DeClue, Ajay Mandal, Lac Lee, Olaf Wiest

J Am Chem Soc· September 2005

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2H, 13C, and 15N kinetic isotope effects on the reaction of the ammonia-rescued K258A mutant of aspartate aminotransferase.
S Kirk Wright, Mark A Rishavy, W W Cleland

Biochemistry· July 2003

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Crystal structure of F65A/Y131C-methylimidazole carbonic anhydrase V reveals architectural features of an engineered proton shuttle.
Kevin M Jude, S Kirk Wright, Chingkuang Tu, David N Silverman, Ronald E Viola

Biochemistry· February 2002

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