Publications by authors named "Koppara Samuel"

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Driving to a Better Understanding of Acyl Glucuronide Transformations Using NMR and Molecular Modeling.
Alexei V Buevich, Cyndi Qixin He, Barbara Pio, Koppara Samuel, Kaushik Mitra

Chem Res Toxicol· March 2022

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Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic.
Jinlong Jiang, Fa-Xiang Ding, Xiaoyan Zhou, Thomas J Bateman, Shuzhi Dong, Koppara Samuel

J Med Chem· June 2021

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Bioactivation of GPR40 Agonist MK-8666: Formation of Protein Adducts in Vitro from Reactive Acyl Glucuronide and Acyl CoA Thioester.
Jackie Shang, Richard Tschirret-Guth, Mark Cancilla, Koppara Samuel, Qing Chen

Chem Res Toxicol· January 2020

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Design, synthesis and biological evaluation of indane derived GPR40 agoPAMs.
Barbara Pio, Harry R Chobanian, Yan Guo, Hubert Josien, William K Hagmann, Koppara Samuel

Bioorg Med Chem Lett· July 2019

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Absorption, metabolism and excretion of [C]omarigliptin, a once-weekly DPP-4 inhibitor, in humans.
Shiyao Xu, Dan Tatosian, Ian Mcintosh, Maria Caceres, Catherine Matthews, Koppara Samuel

Xenobiotica· June 2018

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SAR exploration at the C-3 position of tetrahydro-β-carboline sstr3 antagonists.
Shuwen He, Peter H Dobbelaar, Liangqin Guo, Zhixiong Ye, Jian Liu, Koppara Samuel

Bioorg Med Chem Lett· March 2016

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Discovery of MK-1421, a Potent, Selective sstr3 Antagonist, as a Development Candidate for Type 2 Diabetes.
Shrenik K Shah, Shuwen He, Liangqin Guo, Quang Truong, Hongbo Qi, Koppara Samuel

ACS Med Chem Lett· May 2015

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Investigation of Cardiovascular Effects of Tetrahydro-β-carboline sstr3 antagonists.
Shuwen He, Zhong Lai, Zhixiong Ye, Peter H Dobbelaar, Shrenik K Shah, Koppara Samuel

ACS Med Chem Lett· July 2014

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2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 receptor antagonist with multiple clearance pathways.
Andrew J Kassick, Jinlong Jiang, Jaime Bunda, David Wilson, Jianming Bao, Koppara Samuel

J Med Chem· July 2013

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The Discovery of MK-4256, a Potent SSTR3 Antagonist as a Potential Treatment of Type 2 Diabetes.
Shuwen He, Zhixiong Ye, Quang Truong, Shrenik Shah, Wu Du, Koppara Samuel

ACS Med Chem Lett· June 2012

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Potent, brain-penetrant, hydroisoindoline-based human neurokinin-1 receptor antagonists.
Jinlong Jiang, Jaime L Bunda, Geoge A Doss, Gary G Chicchi, Marc M Kurtz, Koppara Samuel

J Med Chem· May 2009

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Discovery of N-[(1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl]-2-methyl-2- {[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist for the treatment of obesity.
Linus S Lin, Thomas J Lanza, James P Jewell, Ping Liu, Shrenik K Shah, Koppara Samuel

J Med Chem· December 2006

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Addressing the metabolic activation potential of new leads in drug discovery: a case study using ion trap mass spectrometry and tritium labeling techniques.
Koppara Samuel, Wenji Yin, Ralph A Stearns, Yui S Tang, Ashok G Chaudhary

J Mass Spectrom· February 2003

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Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
Steven L Colletti, Jessica L Frie, Elizabeth C Dixon, Suresh B Singh, Bernard K Choi, Koppara Samuel

J Med Chem· January 2003

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Extrapolation of diclofenac clearance from in vitro microsomal metabolism data: role of acyl glucuronidation and sequential oxidative metabolism of the acyl glucuronide.
Sanjeev Kumar, Koppara Samuel, Ramaswamy Subramanian, Matthew P Braun, Ralph A Stearns

J Pharmacol Exp Ther· December 2002

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