Publications by authors named "Larry Higgins"

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Comparative evaluation of rat and human in vitro assays for evaluation of thyroid toxicity.
Laure Asselin, Audrey Baze, Betty Ory, Lucille Wiss, Amélie Schäfer, Larry Higgins

ALTEX· April 2025

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A weight of evidence review on the mode of action, adversity, and the human relevance of xylene's observed thyroid effects in rats.
Keith Morris-Schaffer, Larry Higgins, Neslihan Aygun Kocabas, Frank Faulhammer, Alexandra Cordova

Crit Rev Toxicol· January 2025

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Xylene: weight of evidence approach case study to determine the need for an extended one generation reproductive study with a developmental neurotoxicity animal cohort.
Frank Faulhammer, Martijn Rooseboom, Neslihan Aygun Kocabas, Josje H E Arts, Alexandra Cordova, Larry G Higgins

Crit Rev Toxicol· November 2024

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The short-term toxicity and metabolome of Benzene.
Frank Faulhammer, Bennard van Ravenzwaay, A Robert Schnatter, Martijn Rooseboom, Hennicke Kamp, Larry G Higgins

Toxicol Lett· October 2024

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The short-term toxicity and metabolome of dicyclopentadiene.
Bennard van Ravenzwaay, Neslihan Aygun Kocabas, Frank Faulhammer, Burkhard Flick, Varun Giri, Larry G Higgins

Toxicol Lett· March 2024

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Kinetics of metabolism of deltamethrin and - and -permethrin . Studies using rat and human liver microsomes, isolated rat hepatocytes and rat liver cytosol.
Roger J Price, Mary P Scott, Carina Cantrill, Larry G Higgins, Marjory Moreau

Xenobiotica· January 2021

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Differential lymphatic versus portal vein uptake of the synthetic pyrethroids deltamethrin and cis-permethrin in rats.
Larry G Higgins, Lynsey R Chatham, Sara L Tomczynski, A Kenneth MacLeod, Marjory Moreau

Toxicology· October 2020

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Combining In Vivo and Organotypic In Vitro Approaches to Assess the Human Relevance of Basimglurant (RG7090), a Potential CAR Activator.
Ramona Nudischer, Kasper Renggli, Cristina Bertinetti-Lapatki, Jean-Christophe Hoflack, Nicholas Flint, Larry G Higgins

Toxicol Sci· August 2020

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An assay for screening xenobiotics for inhibition of rat thyroid gland peroxidase activity.
Roger J Price, Rachel Burch, Lynsey R Chatham, Larry G Higgins, Richard A Currie

Xenobiotica· March 2020

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Comparison of the effects of sodium phenobarbital in wild type and humanized constitutive androstane receptor (CAR)/pregnane X receptor (PXR) mice and in cultured mouse, rat and human hepatocytes.
Corinne Haines, Barbara M Elcombe, Lynsey R Chatham, Audrey Vardy, Larry G Higgins

Toxicology· March 2018

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Mode of action and human relevance of THF-induced mouse liver tumors.
Christopher J Choi, Erik K Rushton, Audrey Vardy, Larry Higgins, Andrea Augello

Toxicol Lett· July 2017

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PPARα Is Required for PPARδ Action in Regulation of Body Weight and Hepatic Steatosis in Mice.
Wojciech G Garbacz, Jeffrey T J Huang, Larry G Higgins, Walter Wahli, Colin N A Palmer

PPAR Res· November 2015

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Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.
Azman Abdullah, Neil R Kitteringham, Rosalind E Jenkins, Christopher Goldring, Larry Higgins

Pharmacol Rep· January 2013

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Conditional Expression of Human PPARδ and a Dominant Negative Variant of hPPARδ In Vivo.
Larry G Higgins, Wojciech G Garbacz, Mattias C U Gustafsson, Sitheswaran Nainamalai, Peter R Ashby

PPAR Res· August 2012

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The cap'n'collar transcription factor Nrf2 mediates both intrinsic resistance to environmental stressors and an adaptive response elicited by chemopreventive agents that determines susceptibility to electrophilic xenobiotics.
Larry G Higgins, John D Hayes

Chem Biol Interact· June 2011

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Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents.
Larry G Higgins, John D Hayes

Drug Metab Rev· May 2011

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Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver.
Neil R Kitteringham, Azman Abdullah, Joanne Walsh, Laura Randle, Rosalind E Jenkins, Larry Higgins

J Proteomics· June 2010

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Expression and localization of rat aldo-keto reductases and induction of the 1B13 and 1D2 isoforms by phenolic antioxidants.
A Kenneth MacLeod, Vincent P Kelly, Larry G Higgins, Michael O Kelleher, Sally A Price

Drug Metab Dispos· February 2010

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Activation of the NRF2 signaling pathway by copper-mediated redox cycling of para- and ortho-hydroquinones.
Xiu Jun Wang, John D Hayes, Larry G Higgins, C Roland Wolf, Albena T Dinkova-Kostova

Chem Biol· January 2010

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Characterization of the cancer chemopreventive NRF2-dependent gene battery in human keratinocytes: demonstration that the KEAP1-NRF2 pathway, and not the BACH1-NRF2 pathway, controls cytoprotection against electrophiles as well as redox-cycling compounds.
A Kenneth MacLeod, Michael McMahon, Simon M Plummer, Larry G Higgins, Trevor M Penning

Carcinogenesis· September 2009

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Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents.
Larry G Higgins, Michael O Kelleher, Ian M Eggleston, Ken Itoh, Masayuki Yamamoto

Toxicol Appl Pharmacol· June 2009

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Induction of sulfiredoxin expression and reduction of peroxiredoxin hyperoxidation by the neuroprotective Nrf2 activator 3H-1,2-dithiole-3-thione.
Francesc X Soriano, Frédéric Léveillé, Sofia Papadia, Larry G Higgins, James Varley

J Neurochem· October 2008

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Induction of cancer chemopreventive enzymes by coffee is mediated by transcription factor Nrf2. Evidence that the coffee-specific diterpenes cafestol and kahweol confer protection against acrolein.
Larry G Higgins, Christophe Cavin, Ken Itoh, Masayuki Yamamoto, John D Hayes

Toxicol Appl Pharmacol· February 2008

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Reduction in antioxidant defenses may contribute to ochratoxin A toxicity and carcinogenicity.
Christophe Cavin, Thierry Delatour, Maricel Marin-Kuan, Daisy Holzhäuser, Larry Higgins

Toxicol Sci· March 2007

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Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.
Gail K McWalter, Larry G Higgins, Lesley I McLellan, Colin J Henderson, Lijiang Song

J Nutr· December 2004

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