Publications by authors named "Laura Codarri-Deak"

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PD-1-Cis IL-2R Agonism Determines the Predicted Pharmacological Dose Range for the Immunocytokine Eciskafusp Alfa (PD1-IL2v).
Lucy G Hutchinson, Thomas D Lewin, Laura Lauener, Meret Martin-Facklam, Merlind Muecke

CPT Pharmacometrics Syst Pharmacol· December 2025

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Advanced cytokine-based immunotherapies: targeted cis-delivery strategies for enhanced anti-tumor efficacy and reduced toxicity.
Laurène Pousse, Amrita Manchala, Christian Klein, Laura Codarri Deak

MAbs· December 2025

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PD-1-targeted cis-delivery of an IL-2 variant induces a multifaceted antitumoral T cell response in human lung cancer.
Irene Fusi, Clara Serger, Petra Herzig, Markus Germann, Michael T Sandholzer

Sci Transl Med· September 2025

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PD-1 cis-targeted IL-2v in combination with radiotherapy inhibits lung cancer growth and remodels the immune microenvironment.
Céline Godfroid, Jackeline Romero, Sara Labiano, Chia-Hsien Chuang, Andrea Kelemen

J Immunother Cancer· January 2025

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Selective targeting of IL2Rβγ combined with radiotherapy triggers CD8- and NK-mediated immunity, abrogating metastasis in HNSCC.
Jacob Gadwa, Maria Amann, Thomas E Bickett, Michael W Knitz, Laurel B Darragh

Cell Rep Med· August 2023

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Simultaneous targeting of PD-1 and IL-2Rβγ with radiation therapy inhibits pancreatic cancer growth and metastasis.
Miles Piper, Maureen Hoen, Laurel B Darragh, Michael W Knitz, Diemmy Nguyen

Cancer Cell· May 2023

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Beyond checkpoint inhibition: PD-1 cis-targeting of an IL-2Rβγ-biased interleukin-2 variant as a novel approach to build on checkpoint inhibition.
Laura Codarri Deak, Masao Hashimoto, Pablo Umaña, Christian Klein

Oncoimmunology· April 2023

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Bispecific PD1-IL2v and anti-PD-L1 break tumor immunity resistance by enhancing stem-like tumor-reactive CD8 T cells and reprogramming macrophages.
Mélanie Tichet, Stephan Wullschleger, Agnieszka Chryplewicz, Nadine Fournier, Rachel Marcone

Immunity· January 2023

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Deciphering molecular and cellular ex vivo responses to bispecific antibodies PD1-TIM3 and PD1-LAG3 in human tumors.
Marina Natoli, Klas Hatje, Pratiksha Gulati, Fabian Junker, Petra Herzig, Laura Codarri-Deak

J Immunother Cancer· November 2022

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PD-1-cis IL-2R agonism yields better effectors from stem-like CD8 T cells.
Laura Codarri Deak, Valeria Nicolini, Masao Hashimoto, Maria Karagianni, Petra C Schwalie

Nature· October 2022

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A human receptor occupancy assay to measure anti-PD-1 binding in patients with prior anti-PD-1.
Fabian Junker, Pratiksha Gulati, Uwe Wessels, Stefan Seeber, Kay-Gunnar Stubenrauch, Laura Codarri-Deak

Cytometry A· August 2021

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