Publications by authors named "Leo Price"

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Ex vivo 3D micro-tumour testing platform for predicting clinical response to platinum-based therapy in patients with high-grade serous ovarian cancer.
Esmee Koedoot, Dieudonné J van der Meer, Anne M van Altena, Lieke J Ceton, Timothy J P Sijsenaar, Leo Price

NPJ Precis Oncol· August 2025

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A Patient-Derived 3D Cyst Model of Polycystic Kidney Disease That Mimics Disease Development and Responds to Repurposing Candidates.
Alina Meyer, Bola Khalil, Margarita Iljin, Hester Bange, Leo S Price

Clin Transl Sci· April 2025

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A 3D human co-culture to model neuron-astrocyte interactions in tauopathies.
Kevin L Batenburg, Claudia Sestito, Paulien Cornelissen-Steijger, Jan R T van Weering, Leo S Price

Biol Proced Online· February 2023

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Functional patient-derived organoid screenings identify MCLA-158 as a therapeutic EGFR × LGR5 bispecific antibody with efficacy in epithelial tumors.
Bram Herpers, Berina Eppink, Mark I James, Carme Cortina, Adrià Cañellas-Socias, Leo S Price

Nat Cancer· April 2022

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Differential reprogramming of breast cancer subtypes in 3D cultures and implications for sensitivity to targeted therapy.
Esmee Koedoot, Liesanne Wolters, Marcel Smid, Peter Stoilov, Gerhard A Burger, Leo S Price

Sci Rep· March 2021

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3D imaging of colorectal cancer organoids identifies responses to Tankyrase inhibitors.
Luned M Badder, Andrew J Hollins, Bram Herpers, Kuan Yan, Kenneth B Ewan, Leo S Price

PLoS One· September 2020

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In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease.
Tijmen H Booij, Wouter N Leonhard, Hester Bange, Kuan Yan, Michiel Fokkelman, Leo S Price

J Mol Cell Biol· August 2020

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Renal cyst growth is attenuated by a combination treatment of tolvaptan and pioglitazone, while pioglitazone treatment alone is not effective.
Anish A Kanhai, Hester Bange, Lotte Verburg, Kyra L Dijkstra, Leo S Price

Sci Rep· February 2020

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Prioritization of novel ADPKD drug candidates from disease-stage specific gene expression profiles.
Tareq B Malas, Wouter N Leonhard, Hester Bange, Zoraide Granchi, Kristina M Hettne, Leo S Price

EBioMedicine· January 2020

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High-throughput confocal imaging of differentiated 3D liver-like spheroid cellular stress response reporters for identification of drug-induced liver injury liability.
Steven Hiemstra, Sreenivasa C Ramaiahgari, Steven Wink, Giulia Callegaro, Maarten Coonen, Leo Price

Arch Toxicol· October 2019

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3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis.
Tijmen H Booij, Leo S Price, Erik H J Danen

SLAS Discov· July 2019

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Hydrophilic Auristatin Glycoside Payload Enables Improved Antibody-Drug Conjugate Efficacy and Biocompatibility.
Tero Satomaa, Henna Pynnönen, Anja Vilkman, Titta Kotiranta, Virve Pitkänen, Leo S Price

Antibodies (Basel)· March 2018

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High-Throughput Phenotypic Screening of Kinase Inhibitors to Identify Drug Targets for Polycystic Kidney Disease.
Tijmen H Booij, Hester Bange, Wouter N Leonhard, Kuan Yan, Michiel Fokkelman, Leo S Price

SLAS Discov· September 2017

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Screening out irrelevant cell-based models of disease.
Peter Horvath, Nathalie Aulner, Marc Bickle, Anthony M Davies, Elaine Del Nery, Leo S Price

Nat Rev Drug Discov· November 2016

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Development of a 3D Tissue Culture-Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases.
Tijmen H Booij, Maarten J D Klop, Kuan Yan, Csaba Szántai-Kis, Balint Szokol, Leo S Price

J Biomol Screen· October 2016

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Ultra high content image analysis and phenotype profiling of 3D cultured micro-tissues.
Zi Di, Maarten J D Klop, Vasiliki-Maria Rogkoti, Sylvia E Le Dévédec, Bob van de Water, Leo S Price

PLoS One· December 2015

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MEK inhibition induces apoptosis in osteosarcoma cells with constitutive ERK1/2 phosphorylation.
Zuzanna Baranski, Tijmen H Booij, Marieke L Kuijjer, Yvonne de Jong, Anne-Marie Cleton-Jansen, Leo S Price

Genes Cancer· November 2015

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Aven-mediated checkpoint kinase control regulates proliferation and resistance to chemotherapy in conventional osteosarcoma.
Zuzanna Baranski, Tijmen H Booij, Anne-Marie Cleton-Jansen, Leo S Price, Bob van de Water

J Pathol· July 2015

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Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling.
Alan M Sandercock, Steven Rust, Sandrine Guillard, Kris F Sachsenmeier, Nick Holoweckyj, Leo S Price

Mol Cancer· July 2015

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Epac-Rap signaling reduces oxidative stress in the tubular epithelium.
Geurt Stokman, Yu Qin, Tijmen H Booij, Sreenivasa Ramaiahgari, Marie Lacombe, Leo S Price

J Am Soc Nephrol· July 2014

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A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.
Sreenivasa C Ramaiahgari, Michiel W den Braver, Bram Herpers, Valeska Terpstra, Jan N M Commandeur, Leo S Price

Arch Toxicol· May 2014

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A screen for apoptotic synergism between clinical relevant nephrotoxicant and the cytokine TNF-α.
Giulia Benedetti, Sreenivasa Ramaiahgaris, Bram Herpers, Bob van de Water, Leo S Price

Toxicol In Vitro· December 2013

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Combining doublecortin-like kinase silencing and vinca alkaloids results in a synergistic apoptotic effect in neuroblastoma cells.
Carla S Verissimo, Sou Cheng, Jordi C Puigvert, Yu Qin, Anne Vroon, Leo S Price

J Pharmacol Exp Ther· July 2012

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Automated microinjection of cell-polymer suspensions in 3D ECM scaffolds for high-throughput quantitative cancer invasion screens.
Hoa H Truong, Jan de Sonneville, Veerander P S Ghotra, Jiangling Xiong, Leo Price

Biomaterials· January 2012

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Focal adhesion kinase signaling mediates acute renal injury induced by ischemia/reperfusion.
Yu Qin, Maaike C Alderliesten, Geurt Stokman, Petra Pennekamp, Joseph V Bonventre, Leo S Price

Am J Pathol· December 2011

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