Publications by authors named "Leonid Beigelman"

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Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.
Dorothée Bardiot, David C McGowan, Kusum Gupta, Jerome Deval, Sandra Chang, Leonid Beigelman

J Med Chem· July 2025

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The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.
Sandrine Vendeville, Franck Amblard, Leda Bassit, Leonid N Beigelman, Lawrence M Blatt

J Med Chem· December 2024

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Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.
Koen Vandyck, David C McGowan, Xuan G Luong, Sarah K Stevens, Andreas Jekle, Leonid N Beigelman

J Med Chem· September 2024

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An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Yannick Debing, Hannah Vanrusselt, Lars Degrauwe, Daniel Apolônio Silva de Oliveira, Christopher Kinyanjui Kariuki, Leonid Beigelman

Antiviral Res· April 2024

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Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Andreas Jekle, Santosh Kumar Thatikonda, Ruchika Jaisinghani, Suping Ren, April Kinkade, Leonid Beigelman

Int J Mol Sci· November 2023

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Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Dieudonné Buh Kum, Hannah Vanrusselt, Abel Acosta Sanchez, Valerio Taverniti, Eloi R Verrier, Leonid Beigelman

Hepatology· October 2023

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New Oligonucleotide 2'-O-Alkyl N3'→P5' (Thio)-Phosphoramidates as Potent Antisense Agents: Physicochemical Properties and Biological Activity.
Saúl Martínez-Montero, Vivek K Rajwanshi, Rajendra K Pandey, N Tilani S De Costa, Jin Hong, Leonid Beigelman

Nucleic Acid Ther· October 2023

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Novel non-HAP class A HBV capsid assembly modulators have distinct and profiles.
Hannah Vanrusselt, Dieudonné Buh Kum, Valerio Taverniti, Cheng Liu, Abel Acosta Sanchez, Leonid Beigelman

J Virol· October 2023

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The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor and Confer Resistance To Nirmatrelvir.
Dirk Jochmans, Cheng Liu, Kim Donckers, Antitsa Stoycheva, Sandro Boland, Leonid Beigelman

mBio· February 2023

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Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.
C Cheng Kao, Yuchun Nie, Suping Ren, N Tilani T S De Costa, Rajendra K Pandey, Leonid Beigelman

Mol Ther Nucleic Acids· March 2022

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Targeting TLR9 agonists to secondary lymphoid organs induces potent immune responses against HBV infection.
Irina Ushach, Ren Zhu, Elen Rosler, Rajendra K Pandey, N Tilani S De Costa, Leonid Beigelman

Mol Ther Nucleic Acids· March 2022

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ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Koen Vandyck, Rana Abdelnabi, Kusum Gupta, Dirk Jochmans, Andreas Jekle, Leonid Beigelman

Biochem Biophys Res Commun· May 2021

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Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.
Cheng Liu, Sandro Boland, Michael D Scholle, Dorothee Bardiot, Arnaud Marchand, Leonid Beigelman

Antiviral Res· March 2021

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Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
Xuan G Luong, Sarah K Stevens, Andreas Jekle, Tse-I Lin, Kusum Gupta, Leonid N Beigelman

PLoS One· January 2021

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Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.
Zachary A Gurard-Levin, Cheng Liu, Andreas Jekle, Ruchika Jaisinghani, Suping Ren, Leonid Beigelman

Antiviral Res· October 2020

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Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, Leonid Beigelman

J Med Chem· September 2020

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Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.
Guangyi Wang, Natalia Dyatkina, Marija Prhavc, Caroline Williams, Vladimir Serebryany, Leonid Beigelman

J Med Chem· May 2019

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Safety, tolerability, and pharmacokinetics of AL-335 in healthy volunteers and hepatitis C virus-infected subjects.
Matthew W McClure, Elina Berliba, Tengiz Tsertsvadze, Adrian Streinu-Cercel, Leen Vijgen, Leonid Beigelman

PLoS One· March 2019

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Synthesis of Protected Amino Hexitol Nucleosides as Building Blocks for Oligonucleotide Synthesis.
Swarup De, Amit M Jabgunde, Rahul S Patil, Steven De Jonghe, Leonid Beigelman

J Org Chem· December 2018

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Preclinical Characterization and Human Microdose Pharmacokinetics of ITMN-8187, a Nonmacrocyclic Inhibitor of the Hepatitis C Virus NS3 Protease.
Ravi Rajagopalan, Lin Pan, Caralee Schaefer, John Nicholas, Sharlene Lim, Leonid Beigelman

Antimicrob Agents Chemother· January 2017

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Synthesis and Anti-Influenza Activity of Pyridine, Pyridazine, and Pyrimidine C-Nucleosides as Favipiravir (T-705) Analogues.
Guangyi Wang, Jinqiao Wan, Yujian Hu, Xiangyang Wu, Marija Prhavc, Leonid Beigelman

J Med Chem· May 2016

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Development of a Hyperglycosylated IFN Alfacon-1 (CIFN): Toward Bimonthly or Monthly Dosing for Antiviral Therapies.
Joshua S Taylor, Qingling Zhang, Justin G Julander, Antitsa D Stoycheva, Hua Tan, Leonid N Beigelman

J Interferon Cytokine Res· August 2015

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Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease.
Yutong Jiang, Steven W Andrews, Kevin R Condroski, Brad Buckman, Vlad Serebryany, Leonid Beigelman

J Med Chem· March 2014

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Solid-phase synthesis of 5'-triphosphate 2'-5'-oligoadenylates analogs with 3'-O-biolabile groups and their evaluation as RNase L activators and antiviral drugs.
Yann Thillier, Sarah K Stevens, Christabel Moy, Joshua Taylor, Jean-Jacques Vasseur, Leonid Beigelman

Bioorg Med Chem· September 2013

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2,2-Disubstituted 4-acylthio-3-oxobutyl groups as esterase- and thermolabile protecting groups of phosphodiesters.
Emilia Kiuru, Zafar Ahmed, Harri Lönnberg, Leonid Beigelman, Mikko Ora

J Org Chem· February 2013

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