Publications by authors named "Lesley Howell"

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Identification of a Cannabinoid Receptor 2 Allosteric Site Using Computational Modeling and Pharmacological Analysis.
Zara Farooq, Pietro Delre, Stylianos Iliadis, Giuseppe Felice Mangiatordi, Marialessandra Contino, Lesley A Howell

ACS Pharmacol Transl Sci· February 2025

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Elucidating the Activation Mechanism of the Proton-sensing GPR68 Receptor.
Christos Matsingos, Lesley A Howell, Peter J McCormick, Arianna Fornili

J Mol Biol· August 2024

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Probing GPCR Dimerization Using Peptides.
Zara Farooq, Lesley A Howell, Peter J McCormick

Front Endocrinol (Lausanne)· August 2022

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peptide-directed ligand design complements experimental peptide-directed binding for protein-protein interaction modulator discovery.
Lesley Ann Howell, Andrew Michael Beekman

RSC Chem Biol· February 2021

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Modulation of dopamine D receptors via histamine H receptors is a novel therapeutic target for Huntington's disease.
David Moreno-Delgado, Mar Puigdellívol, Estefanía Moreno, Mar Rodríguez-Ruiz, Joaquín Botta, Lesley A Howell

Elife· June 2020

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Design and development of stapled transmembrane peptides that disrupt the activity of G-protein-coupled receptor oligomers.
Joaquín Botta, Lucka Bibic, Patrick Killoran, Peter J McCormick, Lesley A Howell

J Biol Chem· November 2019

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Singular Location and Signaling Profile of Adenosine A-Cannabinoid CB Receptor Heteromers in the Dorsal Striatum.
Estefanía Moreno, Anna Chiarlone, Mireia Medrano, Mar Puigdellívol, Lucka Bibic, Lesley A Howell

Neuropsychopharmacology· April 2018

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Rac1 plays a role in CXCL12 but not CCL3-induced chemotaxis and Rac1 GEF inhibitor NSC23766 has off target effects on CXCR4.
Shirley C Mills, Lesley Howell, Andrew Beekman, Leanne Stokes, Anja Mueller

Cell Signal· January 2018

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Peptide-Directed Binding for the Discovery of Modulators of α-Helix-Mediated Protein-Protein Interactions: Proof-of-Concept Studies with the Apoptosis Regulator Mcl-1.
Andrew Michael Beekman, Maria Anne O'Connell, Lesley Ann Howell

Angew Chem Int Ed Engl· August 2017

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Design and Characterization of Superpotent Bivalent Ligands Targeting Oxytocin Receptor Dimers via a Channel-Like Structure.
Marta Busnelli, Gunnar Kleinau, Markus Muttenthaler, Stoytcho Stoev, Maurice Manning, Lesley A Howell

J Med Chem· August 2016

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Identification of Small-Molecule Inhibitors of the Antiapoptotic Protein Myeloid Cell Leukaemia-1 (Mcl-1).
Andrew M Beekman, Maria A O'Connell, Lesley A Howell

ChemMedChem· April 2016

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Small-Molecule and Peptide Inhibitors of the Pro-Survival Protein Mcl-1.
Andrew M Beekman, Lesley A Howell

ChemMedChem· April 2016

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Unveiling the "Three-Finger Pharmacophore" Required for p53-MDM2 Inhibition by Saturation-Transfer Difference (STD) NMR Initial Growth-Rates Approach.
Jesus Angulo, Sarah A Goffin, Daivik Gandhi, Mark Searcey, Lesley A Howell

Chemistry· April 2016

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Identification of a new p53/MDM2 inhibitor motif inspired by studies of chlorofusin.
Marco M D Cominetti, Sarah A Goffin, Ewan Raffel, Kerrie D Turner, Jordann C Ramoutar, Lesley A Howell

Bioorg Med Chem Lett· November 2015

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Solid-Phase Synthesis of Duocarmycin Analogues and the Effect of C-Terminal Substitution on Biological Activity.
Michael J Stephenson, Lesley A Howell, Maria A O'Connell, Keith R Fox, Claire Adcock

J Org Chem· October 2015

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Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors.
Xavier Viñals, Estefanía Moreno, Laurence Lanfumey, Arnau Cordomí, Antoni Pastor, Lesley A Howell

PLoS Biol· July 2015

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Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine.
Gemma Navarro, César Quiroz, David Moreno-Delgado, Adam Sierakowiak, Kimberly McDowell, Lesley A Howell

J Neurosci· April 2015

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Identification and characterisation of a G-quadruplex forming sequence in the promoter region of nuclear factor (erythroid-derived 2)-like 2 (Nrf2).
Zoë A E Waller, Lesley A Howell, Colin J Macdonald, Maria A O'Connell, Mark Searcey

Biochem Biophys Res Commun· April 2014

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Non-covalent duplex to duplex crosslinking of DNA in solution revealed by single molecule force spectroscopy.
Benjamin D Rackham, Lesley A Howell, Andrew N Round, Mark Searcey

Org Biomol Chem· December 2013

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A rapid screen for molecules that form duplex to duplex crosslinks in DNA.
María J Marín, Benjamin D Rackham, Andrew N Round, Lesley A Howell, David A Russell

Chem Commun (Camb)· October 2013

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Synthesis of small molecules targeting multiple DNA structures using click chemistry.
Lesley A Howell, Richard A Bowater, Maria A O'Connell, Anthony P Reszka, Stephen Neidle

ChemMedChem· May 2012

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A small molecule that induces assembly of a four way DNA junction at low temperature.
Lesley A Howell, Zoë A E Waller, Richard Bowater, Maria O'Connell, Mark Searcey

Chem Commun (Camb)· August 2011

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Design and synthesis of threading intercalators to target DNA.
Lesley A Howell, Rosul Gulam, Anja Mueller, Maria A O'Connell, Mark Searcey

Bioorg Med Chem Lett· December 2010

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Synthesis and evaluation of 9-aminoacridines derived from benzyne click chemistry.
Lesley A Howell, Aaron Howman, Maria A O'Connell, Anja Mueller, Mark Searcey

Bioorg Med Chem Lett· October 2009

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Targeting higher-order DNA: beyond the G-quadruplex.
Lesley A Howell, Mark Searcey

Chembiochem· September 2009

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