Publications by authors named "Lisa Shewchuk"

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Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library.
Ann M Rowley, Gang Yao, Logan Andrews, Aaron Bedermann, Ross Biddulph, Lisa M Shewchuk

J Med Chem· February 2024

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Discovery of Proline-Based p300/CBP Inhibitors Using DNA-Encoded Library Technology in Combination with High-Throughput Screening.
Xinrong Tian, Dominic Suarez, Douglas Thomson, William Li, Elizabeth A King, Lisa Shewchuk

J Med Chem· November 2022

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Identification of Diarylurea Inhibitors of the Cardiac-Specific Kinase TNNI3K by Designing Selectivity Against VEGFR2, p38α, and B-Raf.
Jaclyn R Patterson, Alan P Graves, Patrick Stoy, Mui Cheung, Tina A Desai, Lisa Shewchuk

J Med Chem· November 2021

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Characterization of Apo-Form Selective Inhibition of Indoleamine 2,3-Dioxygenase*.
Rodrigo F Ortiz-Meoz, Liping Wang, Rosalie Matico, Anna Rutkowska-Klute, Martha De la Rosa, Lisa Shewchuk

Chembiochem· February 2021

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Half-Life Extension of BMP1/TLL Metalloproteinase Inhibitors Using Small-Molecule Human Serum Albumin Binders.
Julien C Vantourout, Andrew M Mason, Josephine Yuen, Graham L Simpson, Ghotas Evindar, Lisa Shewchuk

Bioconjug Chem· February 2021

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The exploration of aza-quinolines as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors with low brain exposure.
Rodolfo Cadilla, David N Deaton, Young Do, Patricia A Elkins, Daniela Ennulat, Lisa M Shewchuk

Bioorg Med Chem· December 2020

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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors.
Curt D Haffner, Adam K Charnley, Christopher J Aquino, Linda Casillas, Máire A Convery, Lisa Shewchuk

ACS Med Chem Lett· November 2019

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The discovery of quinoline-3-carboxamides as hematopoietic prostaglandin D synthase (H-PGDS) inhibitors.
David N Deaton, Young Do, Jason Holt, Michael R Jeune, H Fritz Kramer, Lisa M Shewchuk

Bioorg Med Chem· April 2019

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4,6-Diaminopyrimidines as Highly Preferred Troponin I-Interacting Kinase (TNNI3K) Inhibitors.
Joanne Philp, Brian G Lawhorn, Alan P Graves, Lisa Shewchuk, Katrina L Rivera

J Med Chem· April 2018

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Discovery of a Highly Selective Tankyrase Inhibitor Displaying Growth Inhibition Effects against a Diverse Range of Tumor Derived Cell Lines.
Douglas W Thomson, Anne J Wagner, Marcus Bantscheff, R Edward Benson, Lars Dittus, Lisa Shewchuk

J Med Chem· July 2017

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GSK114: A selective inhibitor for elucidating the biological role of TNNI3K.
Brian G Lawhorn, Joanne Philp, Alan P Graves, Lisa Shewchuk, Dennis A Holt

Bioorg Med Chem Lett· July 2016

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Discovery of 4-Amino-8-quinoline Carboxamides as Novel, Submicromolar Inhibitors of NAD-Hydrolyzing Enzyme CD38.
J David Becherer, Eric E Boros, Tiffany Y Carpenter, David J Cowan, David N Deaton, Lisa M Shewchuk

J Med Chem· September 2015

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Identification of Purines and 7-Deazapurines as Potent and Selective Type I Inhibitors of Troponin I-Interacting Kinase (TNNI3K).
Brian G Lawhorn, Joanne Philp, Yongdong Zhao, Christopher Louer, Marlys Hammond, Lisa Shewchuk

J Med Chem· September 2015

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A pre-steady state and steady state kinetic analysis of the N-ribosyl hydrolase activity of hCD157.
Frank Preugschat, Luke H Carter, Eric E Boros, David J T Porter, Eugene L Stewart, Lisa M Shewchuk

Arch Biochem Biophys· December 2014

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Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase.
Reema K Thalji, Jeff J McAtee, Svetlana Belyanskaya, Martin Brandt, Gregory D Brown, Lisa M Shewchuk

Bioorg Med Chem Lett· June 2013

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Structures of human DPP7 reveal the molecular basis of specific inhibition and the architectural diversity of proline-specific peptidases.
Gustavo Arruda Bezerra, Elena Dobrovetsky, Aiping Dong, Almagul Seitova, Lissete Crombett, Lisa M Shewchuk

PLoS One· February 2013

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Discovery of 7-methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a potent and selective first-in-class inhibitor of protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK).
Jeffrey M Axten, Jesús R Medina, Yanhong Feng, Arthur Shu, Stuart P Romeril, Lisa M Shewchuk

J Med Chem· August 2012

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Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor.
Edgar R Wood, Lisa Shewchuk, Anne Hassel, Jim Nichols, Anne T Truesdale

Biochem Pharmacol· December 2009

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Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R).
Kyle A Emmitte, Brian J Wilson, Erich W Baum, Holly K Emerson, Kevin W Kuntz, Lisa M Shewchuk

Bioorg Med Chem Lett· February 2009

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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Tara R Rheault, Thomas R Caferro, Scott H Dickerson, Kelly H Donaldson, Michael D Gaul, Lisa M Shewchuk

Bioorg Med Chem Lett· February 2009

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Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
Stanley D Chamberlain, Joseph W Wilson, Felix Deanda, Samarjit Patnaik, Anikó M Redman, Lisa Shewchuk

Bioorg Med Chem Lett· January 2009

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Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity.
Stanley D Chamberlain, Anikó M Redman, Joseph W Wilson, Felix Deanda, J Brad Shotwell, Lisa M Shewchuk

Bioorg Med Chem Lett· January 2009

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Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors.
Kirk L Stevens, Michael J Reno, Jennifer B Alberti, Daniel J Price, Laurie S Kane-Carson, Lisa M Shewchuk

Bioorg Med Chem Lett· November 2008

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X-ray crystal structure of the novel enhanced-affinity glucocorticoid agonist fluticasone furoate in the glucocorticoid receptor-ligand binding domain.
Keith Biggadike, Randy K Bledsoe, Anne M Hassell, Barrie E Kirk, Iain M McLay, Lisa M Shewchuk

J Med Chem· June 2008

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6-Ethynylthieno[3,2-d]- and 6-ethynylthieno[2,3-d]pyrimidin-4-anilines as tunable covalent modifiers of ErbB kinases.
Edgar R Wood, Lisa M Shewchuk, Byron Ellis, Perry Brignola, Ronald L Brashear

Proc Natl Acad Sci U S A· February 2008

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