Publications by authors named "Louis Lombardo"

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Structure-activity relationship study of central pyridine-derived TYK2 JH2 inhibitors: Optimization of the PK profile through C4' and C6 variations.
Zili Xiao, Michael G Yang, Chunjian Liu, Trevor Sherwood, John L Gilmore, Louis J Lombardo

Bioorg Med Chem Lett· July 2023

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Long-Acting Tumor-Activated Prodrug of a TGFβR Inhibitor.
Yong Zhang, Karen E Parrish, David R Tortolani, Michael A Poss, Audris Huang, Louis J Lombardo

J Med Chem· November 2021

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Vehicle-related crash deaths: A continuing challenge.
Howard R Champion, Louis Vincent Lombardo

J Trauma Acute Care Surg· October 2021

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Discovery of BMS-986202: A Clinical Tyk2 Inhibitor that Binds to Tyk2 JH2.
Chunjian Liu, James Lin, Charles Langevine, Daniel Smith, Jianqing Li, Louis J Lombardo

J Med Chem· January 2021

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Identification of -Methyl Nicotinamide and -Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2).
Ryan Moslin, Yanlei Zhang, Stephen T Wrobleski, Shuqun Lin, Michael Mertzman, Louis Lombardo

J Med Chem· October 2019

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Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165.
Stephen T Wrobleski, Ryan Moslin, Shuqun Lin, Yanlei Zhang, Steven Spergel, Louis Lombardo

J Med Chem· October 2019

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Identification of Imidazo[1,2-]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
Chunjian Liu, James Lin, Ryan Moslin, John S Tokarski, Jodi Muckelbauer, Louis J Lombardo

ACS Med Chem Lett· March 2019

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Identification of potent tricyclic prodrug S1P receptor modulators.
David Marcoux, Hai-Yun Xiao, T G Murali Dhar, Jenny Xie, Lois D Lehman-McKeeman, Louis J Lombardo

Medchemcomm· April 2017

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Time and place of death from automobile crashes: Research endpoint implications.
Howard R Champion, Louis V Lombardo, Charles E Wade, Ellen J Kalin, Mary M Lawnick

J Trauma Acute Care Surg· September 2016

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Structure-Based Design of Selective Janus Kinase 2 Imidazo[4,5-d]pyrrolo[2,3-b]pyridine Inhibitors.
Amy C Hart, Gretchen M Schroeder, Honghe Wan, James Grebinski, Jennifer Inghrim, Louis J Lombardo

ACS Med Chem Lett· August 2015

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Discovery of a Highly Selective JAK2 Inhibitor, BMS-911543, for the Treatment of Myeloproliferative Neoplasms.
Honghe Wan, Gretchen M Schroeder, Amy C Hart, Jennifer Inghrim, James Grebinski, Louis J Lombardo

ACS Med Chem Lett· August 2015

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9H-Carbazole-1-carboxamides as potent and selective JAK2 inhibitors.
Kurt Zimmermann, Xiaopeng Sang, Harold A Mastalerz, Walter L Johnson, Guifen Zhang, Louis J Lombardo

Bioorg Med Chem Lett· July 2015

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Discovery of Clinical Candidate BMS-906024: A Potent Pan-Notch Inhibitor for the Treatment of Leukemia and Solid Tumors.
Ashvinikumar V Gavai, Claude Quesnelle, Derek Norris, Wen-Ching Han, Patrice Gill, Louis J Lombardo

ACS Med Chem Lett· May 2015

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Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain.
Andrew F Donnell, Christophe Michoud, Kenneth C Rupert, Xiaochun Han, Douglas Aguilar, Louis J Lombardo

J Med Chem· October 2013

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Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain.
Robert F Kester, Andrew F Donnell, Yan Lou, Stacy W Remiszewski, Louis J Lombardo

J Med Chem· October 2013

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Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists.
Gretchen M Schroeder, Donna Wei, Patrizia Banfi, Zhen-Wei Cai, Jonathan Lippy, Louis J Lombardo

Bioorg Med Chem Lett· June 2012

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Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists.
Heidi L Perez, Patrizia Banfi, Jay Bertrand, Zhen-Wei Cai, James W Grebinski, Louis J Lombardo

Bioorg Med Chem Lett· June 2012

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Pyrrolo[1,2-f]triazines as JAK2 inhibitors: achieving potency and selectivity for JAK2 over JAK3.
Lalgudi S Harikrishnan, Muthoni G Kamau, Honghe Wan, Jennifer A Inghrim, Kurt Zimmermann, Louis J Lombardo

Bioorg Med Chem Lett· March 2011

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Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.
David K Williams, Xiao-Tao Chen, Christine Tarby, Robert Kaltenbach, Zhen-Wei Cai, Louis J Lombardo

Bioorg Med Chem Lett· May 2010

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The antiangiogenic activity in xenograft models of brivanib, a dual inhibitor of vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 kinases.
Rajeev S Bhide, Louis J Lombardo, John T Hunt, Zhen-Wei Cai, Joel C Barrish

Mol Cancer Ther· February 2010

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Assessing compound binding to the Eg5 motor domain using a thermal shift assay.
Patricia A McDonnell, Joseph Yanchunas, John A Newitt, Li Tao, Susan E Kiefer, Louis Lombardo

Anal Biochem· September 2009

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The importance of vehicle rollover as a field triage criterion.
Howard R Champion, Louis V Lombardo, Ellen Kalin Shair

J Trauma· August 2009

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Discovery of N-(4-(2-amino-3-chloropyridin-4-yloxy)-3-fluorophenyl)-4-ethoxy-1-(4-fluorophenyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (BMS-777607), a selective and orally efficacious inhibitor of the Met kinase superfamily.
Gretchen M Schroeder, Yongmi An, Zhen-Wei Cai, Xiao-Tao Chen, Cheryl Clark, Louis J Lombardo

J Med Chem· March 2009

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Metabolism of 5-isopropyl-6-(5-methyl-1,3,4-oxadiazol-2-yl)-N-(2-methyl-1H-pyrrolo[2,3-b]pyridin-5-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine (BMS-645737): identification of an unusual N-acetylglucosamine conjugate in the cynomolgus monkey.
Benjamin M Johnson, Amrita V Kamath, John E Leet, Xiaohong Liu, Rajeev S Bhide, Louis J Lombardo

Drug Metab Dispos· December 2008

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Discovery of pyrrolopyridine-pyridone based inhibitors of Met kinase: synthesis, X-ray crystallographic analysis, and biological activities.
Kyoung Soon Kim, Liping Zhang, Robert Schmidt, Zhen-Wei Cai, Donna Wei, Louis J Lombardo

J Med Chem· September 2008

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