Publications by authors named "Louise Major"

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High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.
Laura Aitken, Gemma Baillie, Andrew Pannifer, Angus Morrison, Louise L Major

ACS Chem Biol· July 2025

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Building a cell-factory in Crithidia fasciculata: a bio-sustainable system to produce high-value polyunsaturated fatty acids.
Michela Cerone, Louise L Major, Terry K Smith

Microb Cell Fact· June 2025

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Revisiting the dipeptidyl carboxypeptidase inhibitor captopril as a source of pan anti-trypanosomatid agents.
Jean-Baptiste Garsi, Sofiane Hocine, Raphaël Hensienne, Matthieu Moitessier, Helen Denton, Louise L Major

Bioorg Med Chem Lett· September 2024

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An eggshell-localised annexin plays a key role in the coordination of the life cycle of a plant-parasitic nematode with its host.
James A Price, Mohammad Farhan Ali, Louise L Major, Terry K Smith, John T Jones

PLoS Pathog· February 2023

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Surface-Functionalized Metal-Organic Frameworks for Binding Coronavirus Proteins.
Aamod V Desai, Simon M Vornholt, Louise L Major, Romy Ettlinger, Christian Jansen

ACS Appl Mater Interfaces· February 2023

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Toward Chemical Validation of Leishmania infantum Ribose 5-Phosphate Isomerase as a Drug Target.
Emily A Dickie, Céline Ronin, Mónica Sá, Fabrice Ciesielski, Nathalie Trouche, Louise L Major

Antimicrob Agents Chemother· June 2021

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Synthesis, study of antileishmanial and antitrypanosomal activity of imidazo pyridine fused triazole analogues.
Adinarayana Nandikolla, Singireddi Srinivasarao, Banoth Karan Kumar, Sankaranarayanan Murugesan, Himanshu Aggarwal, Louise L Major

RSC Adv· October 2020

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Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer's Disease Treatment.
Laura Aitken, Ondrej Benek, Brogan E McKelvie, Rebecca E Hughes, Lukas Hroch, Louise L Major

Molecules· July 2019

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Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
Luís Gaspar, Ross P Coron, Paul KongThoo Lin, David M Costa, Begoña Perez-Cabezas, Louise L Major

PLoS Negl Trop Dis· January 2018

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Trypanosoma brucei Bloodstream Forms Depend upon Uptake of myo-Inositol for Golgi Complex Phosphatidylinositol Synthesis and Normal Cell Growth.
Amaia González-Salgado, Michael Steinmann, Louise L Major, Erwin Sigel, Jean-Louis Reymond

Eukaryot Cell· June 2015

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The essential roles of cytidine diphosphate-diacylglycerol synthase in bloodstream form Trypanosoma brucei.
Alison C Lilley, Louise Major, Simon Young, Michael J R Stark, Terry K Smith

Mol Microbiol· May 2014

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Discovery and validation of SIRT2 inhibitors based on tenovin-6: use of a ¹H-NMR method to assess deacetylase activity.
Lisa Pirrie, Anna R McCarthy, Louise L Major, Vaida Morkūnaitė, Asta Zubrienė

Molecules· October 2012

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Synthesis and biological evaluation of CTP synthetase inhibitors as potential agents for the treatment of African trypanosomiasis.
Lucia Tamborini, Andrea Pinto, Terry K Smith, Louise L Major, Maria C Iannuzzi

ChemMedChem· September 2012

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Screening the MayBridge Rule of 3 Fragment Library for Compounds That Interact with the Trypanosoma brucei myo-Inositol-3-Phosphate Synthase and/or Show Trypanocidal Activity.
Louise L Major, Terry K Smith

Mol Biol Int· November 2011

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Synthesis and in vitro/in vivo evaluation of the antitrypanosomal activity of 3-bromoacivicin, a potent CTP synthetase inhibitor.
Paola Conti, Andrea Pinto, Pui E Wong, Louise L Major, Lucia Tamborini

ChemMedChem· February 2011

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Lipidomic analysis of bloodstream and procyclic form Trypanosoma brucei.
Gregory S Richmond, Federica Gibellini, Simon A Young, Louise Major, Helen Denton

Parasitology· August 2010

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RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation.
Changjiang Dong, Louise L Major, Velupillai Srikannathasan, James C Errey, Marie-France Giraud

J Mol Biol· January 2007

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Comparison of characteristics and function of translation termination signals between and within prokaryotic and eukaryotic organisms.
Andrew G Cridge, Louise L Major, Alhad A Mahagaonkar, Elizabeth S Poole, Leif A Isaksson

Nucleic Acids Res· April 2006

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Structure and function of GDP-mannose-3',5'-epimerase: an enzyme which performs three chemical reactions at the same active site.
Louise L Major, Beata A Wolucka, James H Naismith

J Am Chem Soc· December 2005

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The position of a key tyrosine in dTDP-4-Keto-6-deoxy-D-glucose-5-epimerase (EvaD) alters the substrate profile for this RmlC-like enzyme.
Alexandra B Merkel, Louise L Major, James C Errey, Michael D Burkart, Robert A Field

J Biol Chem· July 2004

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Molecular mimicry in the decoding of translational stop signals.
Elizabeth S Poole, Marjan E Askarian-Amiri, Louise L Major, Kim K McCaughan, Debbie-Jane G Scarlett

Prog Nucleic Acid Res Mol Biol· January 2004

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High-resolution structures of RmlC from Streptococcus suis in complex with substrate analogs locate the active site of this class of enzyme.
Changjiang Dong, Louise L Major, Andrew Allen, Wulf Blankenfeldt, Duncan Maskell

Structure· June 2003

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Tandem termination signals: myth or reality?
Louise L Major, Tina D Edgar, Po Yee Yip, Leif A Isaksson, Warren P Tate

FEBS Lett· March 2002

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