Publications by authors named "Luc Nelles"

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Discovery of 9-Cyclopropylethynyl-2-(()-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-]isoquinolin-4-one (GLPG1205), a Unique GPR84 Negative Allosteric Modulator Undergoing Evaluation in a Phase II Clinical Trial.
Frédéric Labéguère, Sonia Dupont, Luke Alvey, Florilène Soulas, Gregory Newsome, Luc Nelles

J Med Chem· November 2020

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Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators.
Gert de Wilde, Maarten Gees, Sara Musch, Katleen Verdonck, Mia Jans, Luc Nelles

Front Pharmacol· May 2019

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Identification and Characterization of Novel CFTR Potentiators.
Maarten Gees, Sara Musch, Steven Van der Plas, Anne-Sophie Wesse, Ann Vandevelde, Luc Nelles

Front Pharmacol· October 2018

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Discovery of N-(3-Carbamoyl-5,5,7,7-tetramethyl-5,7-dihydro-4H-thieno[2,3-c]pyran-2-yl)-lH-pyrazole-5-carboxamide (GLPG1837), a Novel Potentiator Which Can Open Class III Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels to a High Extent.
Steven E Van der Plas, Hans Kelgtermans, Tom De Munck, Sébastien L X Martina, Sébastien Dropsit, Luc Nelles

J Med Chem· February 2018

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Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic.
Mathieu Pizzonero, Sonia Dupont, Marielle Babel, Stéphane Beaumont, Natacha Bienvenu, Luc Nelles

J Med Chem· December 2014

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Triazolopyridines as selective JAK1 inhibitors: from hit identification to GLPG0634.
Christel J Menet, Stephen R Fletcher, Guy Van Lommen, Raphael Geney, Javier Blanc, Luc Nelles

J Med Chem· November 2014

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Preclinical characterization of GLPG0634, a selective inhibitor of JAK1, for the treatment of inflammatory diseases.
Luc Van Rompaey, René Galien, Ellen M van der Aar, Philippe Clement-Lacroix, Luc Nelles

J Immunol· October 2013

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Essential validation of gene trap mouse ES cell lines: a test case with the gene Ttrap.
Liesbeth Vermeire, Abdelilah Ibrahimi, Thierry Voet, Lieve Umans, Kathleen Coddens, Luc Nelles

Int J Dev Biol· October 2009

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Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination.
Camila V Esguerra, Luc Nelles, Liesbeth Vermeire, Abdelilah Ibrahimi, Alexander D Crawford

Development· December 2007

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Neural crest-specific removal of Zfhx1b in mouse leads to a wide range of neurocristopathies reminiscent of Mowat-Wilson syndrome.
Tom Van de Putte, Annick Francis, Luc Nelles, Leo A van Grunsven, Danny Huylebroeck

Hum Mol Genet· June 2007

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Cloning and expression of the cyclophilin Bet v 7, and analysis of immunological cross-reactivity among the cyclophilin A family.
Pascal Cadot, Luc Nelles, Mohammed Srahna, Ellen Dilissen, Jan L Ceuppens

Mol Immunol· February 2006

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Smicl is a novel Smad interacting protein and cleavage and polyadenylation specificity factor associated protein.
Clara Collart, Jacques E Remacle, Silvia Barabino, Leo A van Grunsven, Luc Nelles

Genes Cells· September 2005

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Organization of the mouse Zfhx1b gene encoding the two-handed zinc finger repressor Smad-interacting protein-1.
Luc Nelles, Tom Van de Putte, Leo van Grunsven, Danny Huylebroeck, Kristin Verschueren

Genomics· October 2003

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Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin.
Leo A van Grunsven, Christine Michiels, Tom Van de Putte, Luc Nelles, Gunther Wuytens

J Biol Chem· July 2003

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Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome.
Tom Van de Putte, Mitsuji Maruhashi, Annick Francis, Luc Nelles, Hisato Kondoh

Am J Hum Genet· February 2003

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Generation of the floxed allele of the SIP1 (Smad-interacting protein 1) gene for Cre-mediated conditional knockout in the mouse.
Yujiro Higashi, Mitsuji Maruhashi, Luc Nelles, Tom Van de Putte, Kristin Verschueren

Genesis· February 2002

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