Publications by authors named "Maria Karlgren"

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Animal product-free formation and cultivation of three-dimensional primary hepatocyte spheroids.
Evgeniya Mickols, Rejeen Mohammedamin, Lazaros Primpas, Stina Oredsson, Maria Karlgren

Drug Metab Dispos· October 2025

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OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids.
Evgeniya Mickols, Alina Meyer, Niklas Handin, Malin Stüwe, Jens Eriksson, Maria Karlgren

Sci Rep· July 2024

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Pharmaceutical Quality by Design Approach to Develop High-Performance Nanoparticles for Magnetic Hyperthermia.
Shaquib Rahman Ansari, Yael Del Carmen Suárez-López, Thomas Thersleff, Lennart Häggström, Tore Ericsson, Maria Karlgren

ACS Nano· June 2024

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Integration of Mass Spectrometry Imaging and Machine Learning Visualizes Region-Specific Age-Induced and Drug-Target Metabolic Perturbations in the Brain.
Theodosia Vallianatou, Reza Shariatgorji, Anna Nilsson, Maria Karlgren, Heather Hulme

ACS Chem Neurosci· May 2021

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Expanding the Efflux In Vitro Assay Toolbox: A CRISPR-Cas9 Edited MDCK Cell Line with Human BCRP and Completely Lacking Canine MDR1.
Christine Wegler, Meryem Gazit, Karolina Issa, Sujay Subramaniam, Per Artursson, Maria Karlgren

J Pharm Sci· January 2021

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Acamprosate Is a Substrate of the Human Organic Anion Transporter (OAT) 1 without OAT3 Inhibitory Properties: Implications for Renal Acamprosate Secretion and Drug-Drug Interactions.
Irina E Antonescu, Maria Karlgren, Maria L Pedersen, Ivailo Simoff, Christel A S Bergström

Pharmaceutics· April 2020

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The Permeation of Acamprosate Is Predominantly Caused by Paracellular Diffusion across Caco-2 Cell Monolayers: A Paracellular Modeling Approach.
Irina E Antonescu, Karina F Rasmussen, Sibylle Neuhoff, Xavier Fretté, Maria Karlgren

Mol Pharm· November 2019

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An imidazole based H-Phe-Phe-NH peptidomimetic with anti-allodynic effect in spared nerve injury mice.
Anna Skogh, Anna Lesniak, Christian Sköld, Maria Karlgren, Fabienne Z Gaugaz

Bioorg Med Chem Lett· August 2018

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A mass spectrometry imaging approach for investigating how drug-drug interactions influence drug blood-brain barrier permeability.
Theodosia Vallianatou, Nicole Strittmatter, Anna Nilsson, Mohammadreza Shariatgorji, Gregory Hamm, Maria Karlgren

Neuroimage· May 2018

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A CRISPR-Cas9 Generated MDCK Cell Line Expressing Human MDR1 Without Endogenous Canine MDR1 (cABCB1): An Improved Tool for Drug Efflux Studies.
Maria Karlgren, Ivailo Simoff, Maria Backlund, Christine Wegler, Markus Keiser

J Pharm Sci· September 2017

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Intracellular drug bioavailability: a new predictor of system dependent drug disposition.
André Mateus, Andrea Treyer, Christine Wegler, Maria Karlgren, Pär Matsson

Sci Rep· February 2017

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Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells.
Paola Pellegrini, Matheus Dyczynski, Francesca Vittoria Sbrana, Maria Karlgren, Maria Buoncervello

Oncotarget· June 2016

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Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach.
Anna Vildhede, André Mateus, Elin K Khan, Yurong Lai, Maria Karlgren

Drug Metab Dispos· April 2016

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Complete Knockout of Endogenous Mdr1 (Abcb1) in MDCK Cells by CRISPR-Cas9.
Ivailo Simoff, Maria Karlgren, Maria Backlund, Anne-Christine Lindström, Fabienne Z Gaugaz

J Pharm Sci· February 2016

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Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure.
Anna Vildhede, Jacek R Wiśniewski, Agneta Norén, Maria Karlgren, Per Artursson

J Proteome Res· August 2015

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Hepatic uptake of atorvastatin: influence of variability in transporter expression on uptake clearance and drug-drug interactions.
Anna Vildhede, Maria Karlgren, Elin K Svedberg, Jacek R Wisniewski, Yurong Lai

Drug Metab Dispos· July 2014

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Combined in vitro-in vivo approach to assess the hepatobiliary disposition of a novel oral thrombin inhibitor.
Elin M Matsson, Ulf G Eriksson, Johan E Palm, Per Artursson, Maria Karlgren

Mol Pharm· November 2013

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An integrated in vitro model for simultaneous assessment of drug uptake, metabolism, and efflux.
Etienne P A Neve, Per Artursson, Magnus Ingelman-Sundberg, Maria Karlgren

Mol Pharm· August 2013

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Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
Maria Karlgren, Anna Vildhede, Ulf Norinder, Jacek R Wisniewski, Emi Kimoto

J Med Chem· May 2012

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In vitro and in silico strategies to identify OATP1B1 inhibitors and predict clinical drug-drug interactions.
Maria Karlgren, Gustav Ahlin, Christel A S Bergström, Richard Svensson, Johan Palm

Pharm Res· February 2012

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Molecular genetics and epigenetics of the cytochrome P450 gene family and its relevance for cancer risk and treatment.
Cristina Rodriguez-Antona, Alvin Gomez, Maria Karlgren, Sarah C Sim, Magnus Ingelman-Sundberg

Hum Genet· January 2010

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The expression of the novel CYP2W1 enzyme is an independent prognostic factor in colorectal cancer - a pilot study.
David Edler, Kristina Stenstedt, Katarina Ohrling, Marja Hallström, Maria Karlgren

Eur J Cancer· March 2009

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Expression of CYP2W1 in colon tumors: regulation by gene methylation.
Alvin Gomez, Maria Karlgren, David Edler, Maria Luisa Bernal, Souren Mkrtchian

Pharmacogenomics· October 2007

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Tumour-specific expression of CYP2W1: its potential as a drug target in cancer therapy.
Maria Karlgren, Magnus Ingelman-Sundberg

Expert Opin Ther Targets· January 2007

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Novel aspects of drug metabolism and transport.
Lovisa Afzelius, Magnus Ingelman-Sundberg, Maria Karlgren, Cristina Rodriguez-Antona

Drug News Perspect· December 2006

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