Publications by authors named "Matilda Katan"

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Characterisation of an allosteric site in PLCγ enzymes and implications for development of their specific inhibitors.
Tom D Bunney, Hunter G Nyvall, Calum Macrae, Damjan Lalović, Ashley Gregory, Matilda Katan

Biochem J· October 2025

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Phosphoinositide-specific phospholipase C enzymes: Recent advances in a long journey.
Calum Macrae, Damjan Lalović, Tom D Bunney, Matilda Katan

Biochim Biophys Acta Mol Cell Biol Lipids· June 2025

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Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3.
Alexander J D Snow, Tharushi Wijesiriwardena, Benjamin J Lane, Brendan Farrell, Polly C Dowdle, Matilda Katan

Sci Rep· January 2025

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Characterisation of molecular mechanisms for PLCγ2 disease-linked variants.
Tom D Bunney, Charis Kampyli, Ashley Gregory, Matilda Katan

Adv Biol Regul· December 2024

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The hypermorphic PLCγ2 S707Y variant dysregulates microglial cell function - Insight into PLCγ2 activation in brain health and disease, and opportunities for therapeutic modulation.
Daniel Bull, Julie C Matte, Carmen M Navarron, Rebecca McIntyre, Paul Whiting, Matilda Katan

Biochim Biophys Acta Mol Basis Dis· February 2024

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A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Grace Q Gong, Benoit Bilanges, Ben Allsop, Glenn R Masson, Victoria Roberton, Matilda Katan

Nature· June 2023

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Targeting G-CSF to treat autoinflammation.
Tom D Bunney, Matilda Katan

Nat Immunol· May 2023

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A frequent PLCγ1 mutation in adult T-cell leukemia/lymphoma determines functional properties of the malignant cells.
Christy Prawiro, Tom D Bunney, Charis Kampyli, Hiroko Yaguchi, Matilda Katan

Biochim Biophys Acta Mol Basis Dis· February 2023

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Characterization of the membrane interactions of phospholipase Cγ reveals key features of the active enzyme.
Kyle I P Le Huray, Tom D Bunney, Nikos Pinotsis, Antreas C Kalli, Matilda Katan

Sci Adv· June 2022

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Cells of the human intestinal tract mapped across space and time.
Rasa Elmentaite, Natsuhiko Kumasaka, Kenny Roberts, Aaron Fleming, Emma Dann, Matilda Katan

Nature· September 2021

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Phospholipase C families: Common themes and versatility in physiology and pathology.
Matilda Katan, Shamshad Cockcroft

Prog Lipid Res· November 2020

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Severe Autoinflammatory Manifestations and Antibody Deficiency Due to Novel Hypermorphic PLCG2 Mutations.
Andrea Martín-Nalda, Claudia Fortuny, Lourdes Rey, Tom D Bunney, Laia Alsina, Matilda Katan

J Clin Immunol· October 2020

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Phosphatidylinositol(4,5)bisphosphate: diverse functions at the plasma membrane.
Matilda Katan, Shamshad Cockcroft

Essays Biochem· September 2020

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Targeting the Src Pathway Enhances the Efficacy of Selective FGFR Inhibitors in Urothelial Cancers with FGFR3 Alterations.
Nadia Carvalho Lima, Eliza Atkinson, Tom D Bunney, Matilda Katan, Paul H Huang

Int J Mol Sci· May 2020

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Frequent and Persistent PLCG1 Mutations in Sézary Cells Directly Enhance PLCγ1 Activity and Stimulate NFκB, AP-1, and NFAT Signaling.
Varsha M Patel, Charlotte E Flanagan, Marta Martins, Christine L Jones, Rosie M Butler, Matilda Katan

J Invest Dermatol· February 2020

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Structural insights and activating mutations in diverse pathologies define mechanisms of deregulation for phospholipase C gamma enzymes.
Yang Liu, Tom D Bunney, Sakshi Khosa, Kévin Macé, Katharina Beckenbauer, Matilda Katan

EBioMedicine· January 2020

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Novel Mutation in a Patient With APLAID and Cutis Laxa.
João Farela Neves, Rainer Doffinger, Gabriela Barcena-Morales, Catarina Martins, Olivier Papapietro, Matilda Katan

Front Immunol· October 2019

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Alzheimer's disease phospholipase C-gamma-2 (PLCG2) protective variant is a functional hypermorph.
Lorenza Magno, Christian B Lessard, Marta Martins, Verena Lang, Pedro Cruz, Matilda Katan

Alzheimers Res Ther· February 2019

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NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074.
Domenico Sanfelice, Hans Koss, Tom D Bunney, Gary S Thompson, Brendan Farrell, Matilda Katan

Biomol NMR Assign· October 2018

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Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.
Hans Koss, Tom D Bunney, Diego Esposito, Marta Martins, Matilda Katan

Biophys J· July 2018

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Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System.
Tom D Bunney, Alison J Inglis, Domenico Sanfelice, Brendan Farrell, Christopher J Kerr, Matilda Katan

Structure· March 2018

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Unique signalling connectivity of FGFR3-TACC3 oncoprotein revealed by quantitative phosphoproteomics and differential network analysis.
Benedetta Lombardi, Paul Ashford, Aurelio A Moya-Garcia, Aleksander Rust, Mark Crawford, Matilda Katan

Oncotarget· November 2017

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Conformational transition of FGFR kinase activation revealed by site-specific unnatural amino acid reporter and single molecule FRET.
Louis Perdios, Alan R Lowe, Giorgio Saladino, Tom D Bunney, Nethaji Thiyagarajan, Matilda Katan

Sci Rep· January 2017

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Corrigendum: Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).
Anca Margineanu, Jia Jia Chan, Douglas J Kelly, Sean C Warren, Delphine Flatters, Matilda Katan

Sci Rep· September 2016

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Screening for protein-protein interactions using Förster resonance energy transfer (FRET) and fluorescence lifetime imaging microscopy (FLIM).
Anca Margineanu, Jia Jia Chan, Douglas J Kelly, Sean C Warren, Delphine Flatters, Matilda Katan

Sci Rep· June 2016

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