Publications by authors named "Meacham Harrell"

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Insomnia disorder and cerebrospinal fluid markers of dementia.
Philip Gehrman, Terry McDonald, Holly Barilla, Ruda Lee, Meacham Harrell

J Alzheimers Dis· November 2025

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Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements.
Anthony J Roecker, Swati P Mercer, Jeffrey M Bergman, Kevin F Gilbert, Scott D Kuduk, C Meacham Harrell

Bioorg Med Chem Lett· November 2015

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Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant.
Izzat T Raheem, Michael J Breslin, Joseph Bruno, Tamara D Cabalu, Andrew Cooke, C Meacham Harrell

Bioorg Med Chem Lett· February 2015

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Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Thomas S Reger, M Christa Mattern, Swati P Mercer, Jeffrey M Bergman, C Meacham Harrell

Bioorg Med Chem Lett· October 2014

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Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis.
Anthony J Roecker, Swati P Mercer, C Meacham Harrell, Susan L Garson, Steven V Fox

Bioorg Med Chem Lett· May 2014

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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia.
Anthony J Roecker, Swati P Mercer, John D Schreier, Christopher D Cox, Mark E Fraley, C Meacham Harrell

ChemMedChem· February 2014

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Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs).
Swati P Mercer, Anthony J Roecker, Susan Garson, Duane R Reiss, C Meacham Harrell

Bioorg Med Chem Lett· December 2013

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Discovery of [(2R,5R)-5-{[(5-fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): a dual orexin receptor antagonist with potent sleep-promoting properties.
Paul J Coleman, John D Schreier, Christopher D Cox, Michael J Breslin, David B Whitman, C Meacham Harrell

ChemMedChem· March 2012

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Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia.
Christopher D Cox, Michael J Breslin, David B Whitman, John D Schreier, Georgia B McGaughey, C Meacham Harrell

J Med Chem· July 2010

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Discovery of 3,9-diazabicyclo[4.2.1]nonanes as potent dual orexin receptor antagonists with sleep-promoting activity in the rat.
Paul J Coleman, John D Schreier, Anthony J Roecker, Swati P Mercer, Georgia B McGaughey, C Meacham Harrell

Bioorg Med Chem Lett· July 2010

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Design and synthesis of conformationally constrained N,N-disubstituted 1,4-diazepanes as potent orexin receptor antagonists.
Paul J Coleman, John D Schreier, Georgia B McGaughey, Michael J Bogusky, Christopher D Cox, C Meacham Harrell

Bioorg Med Chem Lett· April 2010

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Discovery of a potent, CNS-penetrant orexin receptor antagonist based on an n,n-disubstituted-1,4-diazepane scaffold that promotes sleep in rats.
David B Whitman, Christopher D Cox, Michael J Breslin, Karen M Brashear, John D Schreier, C Meacham Harrell

ChemMedChem· July 2009

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2-Aminobenzophenones as a novel class of bradykinin B1 receptor antagonists.
Dai-Shi Su, John L Lim, Elizabeth Tinney, Bang-Lin Wan, Kathy L Murphy, C Meacham Harrell

J Med Chem· July 2008

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Proline bis-amides as potent dual orexin receptor antagonists.
Jeffrey M Bergman, Anthony J Roecker, Swati P Mercer, Rodney A Bednar, Duane R Reiss, C Meacham Harrell

Bioorg Med Chem Lett· February 2008

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Potent bradykinin B1 receptor antagonists: 4-substituted phenyl cyclohexanes.
Dai-Shi Su, John L Lim, M Kristine Markowitz, Bang-Lin Wan, Kathy L Murphy, C Meacham Harrell

Bioorg Med Chem Lett· June 2007

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Development of orally bioavailable and CNS penetrant biphenylaminocyclopropane carboxamide bradykinin B1 receptor antagonists.
Scott D Kuduk, Christina N Di Marco, Ronald K Chang, Michael R Wood, Kathy M Schirripa, C Meacham Harrell

J Med Chem· January 2007

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Binding modes of dihydroquinoxalinones in a homology model of bradykinin receptor 1.
Sookhee N Ha, Pat J Hey, Rick W Ransom, C Meacham Harrell, Kathryn L Murphy

Biochem Biophys Res Commun· May 2005

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Development of an efficient and selective radioligand for bradykinin B1 receptor occupancy studies.
Dai-Shi Su, M Kristine Markowitz, Kathy L Murphy, Bang-Lin Wan, Matthew M Zrada, C Meacham Harrell

Bioorg Med Chem Lett· December 2004

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Discovery of a potent, non-peptide bradykinin B1 receptor antagonist.
Dai-Shi Su, M Kristine Markowitz, Robert M DiPardo, Kathy L Murphy, C Meacham Harrell

J Am Chem Soc· June 2003

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