Publications by authors named "Michael Bova"

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Common Pain Disorders in Women: Diagnosis, Treatment, and Rehabilitation Management.
Alexander Shustorovich, Michael Bova, Laurent V Delavaux

Phys Med Rehabil Clin N Am· May 2025

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Answering the Rehabilitation 2030 Call.
Emily Hillaker, Michael Bova, Jina Libby, Maria Tricarico, Patrick Andrews

PM R· September 2024

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Novel Small Molecules Targeting the Intrinsically Disordered Structural Ensemble of α-Synuclein Protect Against Diverse α-Synuclein Mediated Dysfunctions.
Gergely Tóth, Thomas Neumann, Amandine Berthet, Eliezer Masliah, Brian Spencer, Michael Bova

Sci Rep· November 2019

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Have outcomes improved in trauma patients age 90 years and older over the past decade: Experience at a level II trauma center.
Andres X Samayoa, Thai Vu, Tanya Olszewski, Michael Bova, Qi Yan

Am J Surg· June 2018

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Targeting the intrinsically disordered structural ensemble of α-synuclein by small molecules as a potential therapeutic strategy for Parkinson's disease.
Gergely Tóth, Shyra J Gardai, Wagner Zago, Carlos W Bertoncini, Nunilo Cremades, Michael Bova

PLoS One· October 2014

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Label free fragment screening using surface plasmon resonance as a tool for fragment finding - analyzing parkin, a difficult CNS target.
Karin Regnström, Jiangli Yan, Lan Nguyen, Kari Callaway, Yanli Yang, Michael P Bova

PLoS One· February 2014

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Thermodynamic and kinetic characterization of hydroxyethylamine β-secretase-1 inhibitors.
Kalyani Mondal, Karin Regnstrom, Winse Morishige, Robin Barbour, Gary Probst, Michael P Bova

Biochem Biophys Res Commun· November 2013

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Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce α-synuclein phosphorylation in rat brain.
Danielle L Aubele, Roy K Hom, Marc Adler, Robert A Galemmo, Simeon Bowers, Michael P Bova

ChemMedChem· August 2013

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: prime side chromane-containing inhibitors.
Raymond A Ng, Minghua Sun, Simeon Bowers, Roy K Hom, Gary D Probst, Michael P Bova

Bioorg Med Chem Lett· August 2013

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Development of a novel β-secretase binding assay using the AlphaScreen platform.
Zhao Ren, Danny Tam, Ying-Zi Xu, David Wone, Shendong Yuan, Michael P Bova

J Biomol Screen· July 2013

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Discovery of (R)-4-cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline (ELND006) and (R)-4-cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (ELND007): metabolically stable γ-secretase Inhibitors that selectively inhibit the production of amyloid-β over Notch.
Gary Probst, Danielle L Aubele, Simeon Bowers, Darren Dressen, Albert W Garofalo, Michael P Bova

J Med Chem· July 2013

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Design and synthesis of highly selective, orally active Polo-like kinase-2 (Plk-2) inhibitors.
Simeon Bowers, Anh P Truong, Michael Ye, Danielle L Aubele, Jennifer M Sealy, Michael P Bova

Bioorg Med Chem Lett· May 2013

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Design and synthesis of thiophene dihydroisoquinolines as novel BACE1 inhibitors.
Ying-Zi Xu, Shendong Yuan, Simeon Bowers, Roy K Hom, Wayman Chan, Michael P Bova

Bioorg Med Chem Lett· May 2013

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Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.
Simeon Bowers, Ying-zi Xu, Shendong Yuan, Gary D Probst, Roy K Hom, Michael P Bova

Bioorg Med Chem Lett· April 2013

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Discovery of a novel [3.2.1] benzo fused bicyclic sulfonamide-pyrazoles as potent, selective and efficacious γ-secretase inhibitors.
Xiaocong M Ye, Andrei W Konradi, Minghua Sun, Shendong Yuan, Danielle L Aubele, Michael Bova

Bioorg Med Chem Lett· February 2013

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Monitoring signaling by the p75(NTR) receptor utilizing a caspase-3 activation assay amenable to small-molecule screening.
J Michael Bradshaw, Lan Nguyen, William Wallace, Calvin Li, John-Michael Sauer, Michael P Bova

Assay Drug Dev Technol· August 2012

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Quantifying amyloid beta (Aβ)-mediated changes in neuronal morphology in primary cultures: implications for phenotypic screening.
Lan Nguyen, Sarah Wright, Mike Lee, Zhao Ren, John-Michael Sauer, Michael P Bova

J Biomol Screen· July 2012

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Combining label-free technologies: discovery in strength.
Robin Barbour, Michael P Bova

Bioanalysis· March 2012

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Chemoproteomics-based design of potent LRRK2-selective lead compounds that attenuate Parkinson's disease-related toxicity in human neurons.
Nigel Ramsden, Jessica Perrin, Zhao Ren, Byoung Dae Lee, Nico Zinn, Michael Bova

ACS Chem Biol· October 2011

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Design, synthesis and structure-activity relationship of novel [3.3.1] bicyclic sulfonamide-pyrazoles as potent γ-secretase inhibitors.
Danielle L Aubele, Anh P Truong, Darren B Dressen, Gary D Probst, Simeon Bowers, Michael P Bova

Bioorg Med Chem Lett· October 2011

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A label-free approach to identify inhibitors of alpha4beta7-mediated cell adhesion to MadCAM.
Michael P Bova, Lan Nguyen, William Wallace, Caroline Garrido, Ying-Zi Xu

J Biomol Screen· June 2011

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Amino-caprolactam γ-secretase inhibitors showing potential for the treatment of Alzheimer's disease.
Martin L Neitzel, Danielle L Aubele, Jennifer L Marugg, Jacek J Jagodzinski, Andrei W Konradi, Michael P Bova

Bioorg Med Chem Lett· June 2011

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Amyloid precursor protein selective gamma-secretase inhibitors for treatment of Alzheimer's disease.
Guriqbal S Basi, Susanna Hemphill, Elizabeth F Brigham, Anna Liao, Danielle L Aubele, Michael Bova

Alzheimers Res Ther· December 2010

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Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model.
Anh P Truong, Gergley Tóth, Gary D Probst, Jennifer M Sealy, Simeon Bowers, Michael P Bova

Bioorg Med Chem Lett· November 2010

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Design and synthesis of hydroxyethylamine (HEA) BACE-1 inhibitors: structure-activity relationship of the aryl region.
Gary D Probst, Simeon Bowers, Jennifer M Sealy, Brian Stupi, Darren Dressen, Michael P Bova

Bioorg Med Chem Lett· October 2010

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