Publications by authors named "Michael D Threadgill"

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Synthesis, Aromatase Inhibition, Cytotoxicity and Molecular Docking Studies of New Fluorinated and Non-Fluorinated Thiourea Derivatives of Desloratadine.
Muhammad Sajid, Hina Siddiqui, Muhammad Atif, Ruby Sharif, Humaira Zafar, Michael D Threadgill

Chem Biodivers· March 2025

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Thiourea-functionalized aminoglutethimide derivatives as anti-leishmanial agents.
Muhammad Sajid, Hina Siddiqui, Humaira Zafar, Sammer Yousuf, Michael D Threadgill

Future Med Chem· August 2024

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Correction to "Compounds Related to Saudin and Three New Series of Diterpenoids from ".
Sarfaraz Ahmed, Mohammad Nur-E-Alam, Ifat Parveen, Michael D Threadgill, James B Orton

J Nat Prod· October 2023

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Compounds Related to Saudin and Three New Series of Diterpenoids from .
Sarfaraz Ahmed, Mohammad Nur-E-Alam, Ifat Parveen, Michael D Threadgill, James B Orton

J Nat Prod· May 2023

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Macrolides from rare actinomycetes: Structures and bioactivities.
Ammar A Al-Fadhli, Michael D Threadgill, Faez Mohammed, Paul Sibley, Wadie Al-Ariqi

Int J Antimicrob Agents· February 2022

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Racemases and epimerases operating through a 1,1-proton transfer mechanism: reactivity, mechanism and inhibition.
Matthew D Lloyd, Maksims Yevglevskis, Amit Nathubhai, Tony D James, Michael D Threadgill

Chem Soc Rev· May 2021

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A neoclerodane orthoester and other new neoclerodane diterpenoids from Teucrium yemense chemistry and effect on secretion of insulin.
Mohammad Nur-E-Alam, Ifat Parveen, Barrie Wilkinson, Sarfaraz Ahmed, Rahman M Hafizur, Michael D Threadgill

Sci Rep· April 2021

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Derivatives of a PARP Inhibitor TIQ-A through the Synthesis of 8-Alkoxythieno[2,3-]isoquinolin-5(4)-ones.
Mirko M Maksimainen, Antti Nurmesjärvi, Reima A Terho, Michael D Threadgill, Lari Lehtiö

ACS Omega· June 2020

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Stimulation of insulin secretion by 5-methylcoumarins and its sulfur analogues isolated from Clutia lanceolata Forssk.
Sarfaraz Ahmed, Mohammad Nur-E-Alam, Ifat Parveen, Simon J Coles, Rahman M Hafizur, Michael D Threadgill

Phytochemistry· February 2020

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Novel 2-arylthiopropanoyl-CoA inhibitors of α-methylacyl-CoA racemase 1A (AMACR; P504S) as potential anti-prostate cancer agents.
Maksims Yevglevskis, Amit Nathubhai, Katty Wadda, Guat L Lee, Suzanne Al-Rawi, Michael D Threadgill

Bioorg Chem· November 2019

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Identification of novel small-molecule inhibitors of α-methylacyl-CoA racemase (AMACR; P504S) and structure-activity relationships.
Yoana D Petrova, Katty Wadda, Amit Nathubhai, Maksims Yevglevskis, Paul J Mitchell, Michael D Threadgill

Bioorg Chem· November 2019

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New flavonoids from the Saudi Arabian plant Retama raetam which stimulates secretion of insulin and inhibits α-glucosidase.
Mohammad Nur-E-Alam, Muhammad Yousaf, Ifat Parveen, Rahman M Hafizur, Usman Ghani, Michael D Threadgill

Org Biomol Chem· January 2019

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Structure-activity relationships of rationally designed AMACR 1A inhibitors.
Maksims Yevglevskis, Guat L Lee, Amit Nathubhai, Yoana D Petrova, Tony D James, Michael D Threadgill

Bioorg Chem· September 2018

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25th Conference of GP2A.
Michael D Threadgill, Susan E Matthews, Francesca Giuntini

Pharmaceuticals (Basel)· December 2017

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Mono-ADP-ribosylation of histone 3 at arginine-117 promotes proliferation through its interaction with P300.
Feng Ling, Yi Tang, Ming Li, Qing-Shu Li, Xian Li, Michael D Threadgill

Oncotarget· September 2017

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Neoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense.
Mohammad Nur-E-Alam, Muhammad Yousaf, Sarfaraz Ahmed, Ebtesam S Al-Sheddi, Ifat Parveen, Michael D Threadgill

J Nat Prod· June 2017

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A novel colorimetric assay for α-methylacyl-CoA racemase 1A (AMACR; P504S) utilizing the elimination of 2,4-dinitrophenolate.
Maksims Yevglevskis, Guat L Lee, Amit Nathubhai, Yoana D Petrova, Tony D James, Michael D Threadgill

Chem Commun (Camb)· May 2017

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Highly Potent and Isoform Selective Dual Site Binding Tankyrase/Wnt Signaling Inhibitors That Increase Cellular Glucose Uptake and Have Antiproliferative Activity.
Amit Nathubhai, Teemu Haikarainen, Jarkko Koivunen, Sudarshan Murthy, Françoise Koumanov, Michael D Threadgill

J Med Chem· January 2017

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5-Aminoisoquinolin-1-one (5-AIQ), a Water-Soluble Inhibitor of the Poly(ADP-Ribose)Polymerases (PARPs).
Michael D Threadgill

Curr Med Chem· August 2016

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Structure-activity relationships of 2-arylquinazolin-4-ones as highly selective and potent inhibitors of the tankyrases.
Amit Nathubhai, Teemu Haikarainen, Penelope C Hayward, Silvia Muñoz-Descalzo, Andrew S Thompson, Michael D Threadgill

Eur J Med Chem· August 2016

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Exploration of the nicotinamide-binding site of the tankyrases, identifying 3-arylisoquinolin-1-ones as potent and selective inhibitors in vitro.
Helen A Paine, Amit Nathubhai, Esther C Y Woon, Peter T Sunderland, Pauline J Wood, Michael D Threadgill

Bioorg Med Chem· September 2015

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Initial development of a cytotoxic amino-seco-CBI warhead for delivery by prodrug systems.
Elvis A Twum, Amit Nathubhai, Pauline J Wood, Matthew D Lloyd, Andrew S Thompson, Michael D Threadgill

Bioorg Med Chem· July 2015

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Structure-based design, synthesis and evaluation in vitro of arylnaphthyridinones, arylpyridopyrimidinones and their tetrahydro derivatives as inhibitors of the tankyrases.
Katerina Kumpan, Amit Nathubhai, Chenlu Zhang, Pauline J Wood, Matthew D Lloyd, Michael D Threadgill

Bioorg Med Chem· July 2015

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ART1 promotes starvation-induced autophagy: a possible protective role in the development of colon carcinoma.
Yi Tang, Ming Li, Ya-Lan Wang, Michael D Threadgill, Ming Xiao

Am J Cancer Res· May 2015

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The perils of rational design--unexpected irreversible elimination of fluoride from 3-fluoro-2-methylacyl-CoA esters catalysed by α-methylacyl-CoA racemase (AMACR; P504S).
Maksims Yevglevskis, Guat L Lee, Michael D Threadgill, Timothy J Woodman, Matthew D Lloyd

Chem Commun (Camb)· November 2014

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