Publications by authors named "Michael Sinz"

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Identification and characterization of a novel ergothioneine conjugate of raloxifene.
Abhijith Rao, Sivaprasad Putluru, Prasanth Eapen, Hemantha Kumar, Raviraj Landge, Michael Sinz

Drug Metab Dispos· February 2025

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A close examination of BCRP's role in lactation and methods for predicting drug distribution into milk.
Caroline Sychterz, Hong Shen, Yueping Zhang, Michael Sinz, Amin Rostami-Hodjegan

CPT Pharmacometrics Syst Pharmacol· November 2024

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A Pilot Study To Assess the Suitability of Riboflavin As a Surrogate Marker of Breast Cancer Resistance Protein in Healthy Participants.
Hong Shen, Runlan Huo, Yueping Zhang, Linna Wang, Nian Tong, Michael Sinz

J Pharmacol Exp Ther· July 2024

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Evaluation of Encequidar as An Intestinal P-gp and BCRP Specific Inhibitor to Assess the Role of Intestinal P-gp and BCRP in Drug-Drug Interactions.
Jessica Chu, Erika Panfen, Linna Wang, Anthony Marino, Xue-Qing Chen, Michael Sinz

Pharm Res· November 2023

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Metabolomic Profiling and Drug Interaction Characterization Reveal Riboflavin As a Breast Cancer Resistance Protein-Specific Endogenous Biomarker That Demonstrates Prediction of Transporter Activity In Vivo.
Yueping Zhang, Petia A Shipkova, Bethanne M Warrack, David M Nelson, Linna Wang, Michael Sinz

Drug Metab Dispos· July 2023

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Synthesis and biological evaluation of biaryl alkyl ethers as inhibitors of IDO1.
Jay A Markwalder, Aaron J Balog, David K Williams, Susheel J Nara, Ratnakar Reddy, Michael W Sinz

Bioorg Med Chem Lett· May 2023

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Development of BET Inhibitors as Potential Treatments for Cancer: Optimization of Pharmacokinetic Properties.
Matthew D Hill, Haiquan Fang, Derek Norris, George V Delucca, Hong Huang, Michael Sinz

ACS Med Chem Lett· July 2022

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Development of BET inhibitors as potential treatments for cancer: A new carboline chemotype.
Matthew D Hill, Claude Quesnelle, John Tokarski, Haiquan Fang, Carolynn Fanslau, Michael Sinz

Bioorg Med Chem Lett· November 2021

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Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Sagnik Chatterjee, Sambuddho Mukherjee, L V J Sankara Sivaprasad, Tanvi Naik, Shashyendra Singh Gautam, Michael Sinz

J Pharmacol Exp Ther· January 2021

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Absence of OATP1B (Organic Anion-Transporting Polypeptide) Induction by Rifampin in Cynomolgus Monkeys: Determination Using the Endogenous OATP1B Marker Coproporphyrin and Tissue Gene Expression.
Yueping Zhang, Cliff Chen, Shen-Jue Chen, Xue-Qing Chen, David J Shuster, Michael Sinz

J Pharmacol Exp Ther· October 2020

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Detection of Weak Organic Anion-Transporting Polypeptide 1B Inhibition by Probenecid with Plasma-Based Coproporphyrin in Humans.
Yueping Zhang, Vinay K Holenarsipur, Hamza Kandoussi, Jianing Zeng, T Thanga Mariappan, Michael Sinz

Drug Metab Dispos· October 2020

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Absorption and Disposition of Coproporphyrin I (CPI) in Cynomolgus Monkeys and Mice: Pharmacokinetic Evidence to Support the Use of CPI to Inform the Potential for Organic Anion-Transporting Polypeptide Inhibition.
Xiaomei Gu, Lifei Wang, Jinping Gan, R Marcus Fancher, Yuan Tian, Michael Sinz

Drug Metab Dispos· August 2020

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Identification of novel glutathione conjugates of terbinafine in liver microsomes and hepatocytes across species.
Amol Patil, Mayurbhai Kathadbhai Ladumor, Shyam H Kamble, Benjamin M Johnson, Murali Subramanian, Michael W Sinz

Xenobiotica· December 2019

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Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.
Erika Panfen, Weiqi Chen, Yueping Zhang, Michael Sinz, Punit Marathe

Drug Metab Dispos· November 2019

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Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Hong Shen, Ming Yao, Michael Sinz, Punit Marathe, A David Rodrigues

Mol Pharm· September 2019

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Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.
Yueping Zhang, Erika Panfen, Marcus Fancher, Michael Sinz, Punit Marathe

Mol Pharm· June 2019

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Preface.
Michael Sinz

Curr Drug Metab· January 2019

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Preface.
Michael W Sinz

Curr Drug Metab· October 2018

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Evaluation of Farnesoid X Receptor Target Gene Induction in Human Hepatocytes: Amino Acid Conjugation.
Jean Simmermacher, Michael Sinz

Drug Metab Lett· October 2018

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A Novel Liquid Chromatography Tandem Mass Spectrometry Method for the Estimation of Bilirubin Glucuronides and its Application to In Vitro Enzyme Assays.
Siva P Putluru, Murali K Matta, Deepak Ahire, Murali Subramanian, Michael Sinz

Drug Metab Lett· May 2018

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BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder.
Lawrence R Marcin, Jayakumar Warrier, Srinivasan Thangathirupathy, Jianliang Shi, George N Karageorge, Michael Sinz

ACS Med Chem Lett· May 2018

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Preclinical Characterization of ()-3-((3,4)-3-fluoro-4-(4-hydroxyphenyl)piperidin-1-yl)-1-(4-methylbenzyl)pyrrolidin-2-one (BMS-986169), a Novel, Intravenous, Glutamate -Methyl-d-Aspartate 2B Receptor Negative Allosteric Modulator with Potential in Major Depressive Disorder.
Linda J Bristow, Jyoti Gulia, Michael R Weed, Bettadapura N Srikumar, Yu-Wen Li, Michael Sinz

J Pharmacol Exp Ther· December 2017

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Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Niresh Hariparsad, Diane Ramsden, Jairam Palamanda, Joshua G Dekeyser, Odette A Fahmi, Michael Sinz

Drug Metab Dispos· October 2017

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Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies.
Kap-Sun Yeung, Brett R Beno, Kyle Parcella, John A Bender, Katherine A Grant-Young, Michael Sinz

J Med Chem· May 2017

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Discovery of a Potent Acyclic, Tripeptidic, Acyl Sulfonamide Inhibitor of Hepatitis C Virus NS3 Protease as a Back-up to Asunaprevir with the Potential for Once-Daily Dosing.
Li-Qiang Sun, Eric Mull, Barbara Zheng, Stanley D'Andrea, Qian Zhao, Michael W Sinz

J Med Chem· September 2016

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