Publications by authors named "Punit Marathe"

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Discovery of liver-selective glucokinase activators comprising N-(4-alkylthiazol-2-yl)benzamides and N-(3-alkyl-1,2,4-thiadiazol-5-yl)benzamides for the treatment of metabolic disorders.
David S Yoon, Shung Wu, Sean S Chen, Rebecca A Smirk, Robert P Brigance, Punit Marathe

Bioorg Med Chem Lett· July 2025

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Response to Mitapivat: A Quinolone Sulfonamide to Manage Hemolytic Anemia in Adults With Pyruvate Kinase Deficiency.
Audra Boscoe, Rebecca McCracken, Punit Marathe, Kareem Osman

Am J Ther· August 2024

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Reporting on Therapeutic Advancements Requires Accurate Language.
Rebecca McCracken, Audra Boscoe, Punit Marathe, Kareem Osman

Am J Ther· July 2024

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Volumetric absorptive microsampling as an effective microsampling technique for LC-MS/MS bioanalysis of biomarkers in drug discovery.
Unnati Kapadnis, Chuck Locuson, Heidi Okamura, Gianluca De Rienzo, Cece Cotter, Punit Marathe

Bioanalysis· July 2023

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Current Approaches for Predicting Human PK for Small Molecule Development Candidates: Findings from the IQ Human PK Prediction Working Group Survey.
Carl Petersson, Xin Zhou, Joerg Berghausen, David Cebrian, Michael Davies, Punit Marathe

AAPS J· July 2022

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Pharmacokinetics of 40 kDa Polyethylene glycol (PEG) in mice, rats, cynomolgus monkeys and predicted pharmacokinetics in humans.
Nidhi Sharda, Purnima Khandelwal, Lisa Zhang, Janet Caceres-Cortes, Punit Marathe

Eur J Pharm Sci· October 2021

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Pharmacological Optimization for Successful Traumatic Brain Injury Drug Development.
Samuel M Poloyac, Richard J Bertz, Lee A McDermott, Punit Marathe

J Neurotrauma· November 2020

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A novel semi-mechanistic tumor growth fraction model for translation of preclinical efficacy of anti-glypican 3 antibody drug conjugate to human.
Renu Singh, Alexander Kozhich, Chin Pan, Francis Lee, Pina Cardarelli, Punit Marathe

Biopharm Drug Dispos· November 2020

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Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A.
Erika Panfen, Weiqi Chen, Yueping Zhang, Michael Sinz, Punit Marathe

Drug Metab Dispos· November 2019

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Renal Excretion of Dabigatran: The Potential Role of Multidrug and Toxin Extrusion (MATE) Proteins.
Hong Shen, Ming Yao, Michael Sinz, Punit Marathe, A David Rodrigues

Mol Pharm· September 2019

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Pharmacokinetics of 40 kDa PEG in rodents using high-field NMR spectroscopy.
Purnima Khandelwal, Lisa Zhang, Anjaneya Chimalakonda, Janet Caceres-Cortes, Christine Huang, Punit Marathe

J Pharm Biomed Anal· July 2019

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Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate.
Yueping Zhang, Erika Panfen, Marcus Fancher, Michael Sinz, Punit Marathe

Mol Pharm· June 2019

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Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.
Hong Shen, Vinay K Holenarsipur, T Thanga Mariappan, Dieter M Drexler, Joseph L Cantone, Punit Marathe

J Pharmacol Exp Ther· January 2019

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UHPLC-MS/MS bioanalysis of human plasma coproporphyrins as potential biomarkers for organic anion-transporting polypeptide-mediated drug interactions.
Hamza Kandoussi, Jianing Zeng, Kumar Shah, Patricia Paterson, Rasa Santockyte, Punit Marathe

Bioanalysis· May 2018

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Discovery and Validation of Pyridoxic Acid and Homovanillic Acid as Novel Endogenous Plasma Biomarkers of Organic Anion Transporter (OAT) 1 and OAT3 in Cynomolgus Monkeys.
Hong Shen, David M Nelson, Regina V Oliveira, Yueping Zhang, Colleen A Mcnaney, Punit Marathe

Drug Metab Dispos· February 2018

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Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs.
Li Di, Christopher Breen, Rob Chambers, Sean T Eckley, Robert Fricke, Punit Marathe

J Pharm Sci· December 2017

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Physiologically Based Pharmacokinetic Modeling of Transporter-Mediated Hepatic Clearance and Liver Partitioning of OATP and OCT Substrates in Cynomolgus Monkeys.
Bridget L Morse, Jamus G MacGuire, Anthony M Marino, Yue Zhao, Maxine Fox, Punit Marathe

AAPS J· November 2017

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Endogenous Biomarkers to Assess Drug-Drug Interactions by Drug Transporters and Enzymes.
T Thanga Mariappan, Hong Shen, Punit Marathe

Curr Drug Metab· October 2017

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Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.
Hong Shen, Weiqi Chen, Dieter M Drexler, Sandhya Mandlekar, Vinay K Holenarsipur, Punit Marathe

Drug Metab Dispos· August 2017

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Unmasking the Role of Uptake Transporters for Digoxin Uptake Across the Barriers of the Central Nervous System in Rat.
Kunal S Taskar, T Thanga Mariappan, Vishwanath Kurawattimath, Shashyendra Singh Gautam, T V Radhakrishna Mullapudi, Punit Marathe

J Cent Nerv Syst Dis· March 2017

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Challenges and Opportunities with Non-CYP Enzymes Aldehyde Oxidase, Carboxylesterase, and UDP-Glucuronosyltransferase: Focus on Reaction Phenotyping and Prediction of Human Clearance.
Upendra A Argikar, Philip M Potter, J Matthew Hutzler, Punit H Marathe

AAPS J· November 2016

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Coproporphyrins in Plasma and Urine Can Be Appropriate Clinical Biomarkers to Recapitulate Drug-Drug Interactions Mediated by Organic Anion Transporting Polypeptide Inhibition.
Yurong Lai, Sandhya Mandlekar, Hong Shen, Vinay K Holenarsipur, Robert Langish, Punit Marathe

J Pharmacol Exp Ther· September 2016

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Small Molecule Reversible Inhibitors of Bruton's Tyrosine Kinase (BTK): Structure-Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177).
George V De Lucca, Qing Shi, Qingjie Liu, Douglas G Batt, Myra Beaudoin Bertrand, Punit Marathe

J Med Chem· September 2016

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Coproporphyrins I and III as Functional Markers of OATP1B Activity: In Vitro and In Vivo Evaluation in Preclinical Species.
Hong Shen, Jun Dai, Tongtong Liu, Yaofeng Cheng, Weiqi Chen, Punit Marathe

J Pharmacol Exp Ther· May 2016

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Disruption of BSEP Function in HepaRG Cells Alters Bile Acid Disposition and Is a Susceptive Factor to Drug-Induced Cholestatic Injury.
Xi Qiu, Yueping Zhang, Tongtong Liu, Hong Shen, Yongling Xiao, Punit Marathe

Mol Pharm· April 2016

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