Publications by authors named "Michael Winther"

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Improving prescribing: a feasibility study of pharmacogenetic testing with clinical decision support in primary healthcare in Singapore.
Helen Smith, Martin Dawes, Hagit Katzov-Eckert, Sarah Burrell, Sam Xin Hui, Michael D Winther

Fam Pract· August 2024

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Southeast Asian Pharmacogenomics Research Network (SEAPharm): Current Status and Perspectives.
Supatat Chumnumwat, Zen Huat Lu, Chonlaphat Sukasem, Michael David Winther, Francis R Capule

Public Health Genomics· May 2020

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CYP2C19 phenotype in South-East Asian Acute Coronary Syndrome patients and impact on major adverse cardiovascular events.
Doreen Su-Yin Tan, Jernice Wan Xin Aw, Michael Winther, Liuh Ling Goh, Hean Yee Ong

J Clin Pharm Ther· February 2020

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In search of a genetic explanation for LDLc variability in an FH family: common SNPs and a rare mutation in explain only part of LDL variability in an FH family.
Michael Winther, Shoshi Shpitzen, Or Yaacov, Jakob Landau, Limor Oren

J Lipid Res· October 2019

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Economic burden of adverse drug reactions and potential for pharmacogenomic testing in Singaporean adults.
Sze Ling Chan, Hong Yen Ng, Cynthia Sung, Alexandre Chan, Michael D Winther

Pharmacogenomics J· August 2019

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Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial.
Nicholas L Syn, Andrea Li-Ann Wong, Soo-Chin Lee, Hock-Luen Teoh, James Wei Luen Yip, Michael D Winther

BMC Med· July 2018

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Pharmacogenomics in Asia: a systematic review on current trends and novel discoveries.
Hazel Xiaohui Ang, Sze Ling Chan, Levana L Sani, Clarissa Bernice Quah, Liam R Brunham, Michael D Winther

Pharmacogenomics· June 2017

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Prevalence and characteristics of adverse drug reactions at admission to hospital: a prospective observational study.
Sze Ling Chan, Xiaohui Ang, Levana L Sani, Hong Yen Ng, Michael D Winther

Br J Clin Pharmacol· December 2016

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Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.
Shaoyi Sun, Zaihui Zhang, Natalia Pokrovskaia, Sultan Chowdhury, Qi Jia, Michael D Winther

Bioorg Med Chem· February 2015

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Identification of four novel genes contributing to familial elevated plasma HDL cholesterol in humans.
Roshni R Singaraja, Ian Tietjen, G Kees Hovingh, Patrick L Franchini, Chris Radomski, Michael Winther

J Lipid Res· August 2014

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Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease.
Zaihui Zhang, Natalie A Dales, Michael D Winther

J Med Chem· June 2014

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Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.
Shaoyi Sun, Zaihui Zhang, Vandna Raina, Natalia Pokrovskaia, Duanjie Hou, Michael D Winther

Bioorg Med Chem Lett· January 2014

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Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases.
Shaoyi Sun, Zaihui Zhang, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Julia Fonarev, Michael D Winther

Bioorg Med Chem Lett· January 2014

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Discovery of XEN445: a potent and selective endothelial lipase inhibitor raises plasma HDL-cholesterol concentration in mice.
Shaoyi Sun, Richard Dean, Qi Jia, Alla Zenova, Jing Zhong, Michael D Winther

Bioorg Med Chem· December 2013

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Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands.
Josef G Meingassner, Heinrich Aschauer, Anthony P Winiski, Natalie Dales, David Yowe, Michael D Winther

J Invest Dermatol· August 2013

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The impact of partial and complete loss-of-function mutations in endothelial lipase on high-density lipoprotein levels and functionality in humans.
Roshni R Singaraja, Suthesh Sivapalaratnam, Kees Hovingh, Marie-Pierre Dubé, José Castro-Perez, Michael Winther

Circ Cardiovasc Genet· February 2013

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Discovery of piperazin-1-ylpyridazine-based potent and selective stearoyl-CoA desaturase-1 inhibitors for the treatment of obesity and metabolic syndrome.
Zaihui Zhang, Shaoyi Sun, Vishnumurthy Kodumuru, Duanjie Hou, Shifeng Liu, Michael D Winther

J Med Chem· January 2013

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Use of bioanalyzer electropherograms for quality control and target evaluation in microarray expression profiling studies of ocular tissues.
Christina A Harrington, Michael Winther, Michelle M Garred

J Ocul Biol Dis Infor· December 2009

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