Publications by authors named "Natalie Dales"

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Discovery and Optimization of First-in-Class Molecular Glue Degraders of the WIZ Transcription Factor for Fetal Hemoglobin Induction to Treat Sickle Cell Disease.
John Ryan Kerrigan, Noel M Thomsen, Artiom Cernijenko, Sarah E Kochanek, Janetta Dewhurst, Natalie A Dales

J Med Chem· November 2024

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A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Pamela Y Ting, Sneha Borikar, John Ryan Kerrigan, Noel M Thomsen, Eamon Aghania, Natalie A Dales

Science· July 2024

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Discovery and characterization of a selective IKZF2 glue degrader for cancer immunotherapy.
Simone Bonazzi, Eva d'Hennezel, Rohan E J Beckwith, Lei Xu, Aleem Fazal, Natalie A Dales

Cell Chem Biol· March 2023

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An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion.
Caroline Gubser Keller, Youngah Shin, Alex Mas Monteys, Nicole Renaud, Martin Beibel, Natalie Dales

Nat Commun· March 2022

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Use of Intramolecular 1,5-Sulfur-Oxygen and 1,5-Sulfur-Halogen Interactions in the Design of -Methyl-5-aryl--(2,2,6,6-tetramethylpiperidin-4-yl)-1,3,4-thiadiazol-2-amine SMN2 Splicing Modulators.
Jake Axford, Moo Je Sung, John Manchester, Donovan Chin, Monish Jain, Natalie A Dales

J Med Chem· April 2021

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BET bromodomain inhibitors regulate keratinocyte plasticity.
Gabi Schutzius, Christian Kolter, Sebastian Bergling, Federico Tortelli, Florian Fuchs, Natalie Dales

Nat Chem Biol· March 2021

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Discovery of a novel indole pharmacophore for the irreversible inhibition of myeloperoxidase (MPO).
Anup Patnaik, Laura Axford, Lin Deng, Evan Cohick, Xianglin Ren, Natalie Dales

Bioorg Med Chem· June 2020

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Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).
Atwood K Cheung, Brian Hurley, Ryan Kerrigan, Lei Shu, Donovan N Chin, Natalie A Dales

J Med Chem· December 2018

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Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Natalie A Dales

Nat Chem Biol· April 2016

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Corrigendum: SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Natalie A Dales

Nat Chem Biol· September 2015

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SMN2 splice modulators enhance U1-pre-mRNA association and rescue SMA mice.
James Palacino, Susanne E Swalley, Cheng Song, Atwood K Cheung, Lei Shu, Natalie A Dales

Nat Chem Biol· July 2015

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Discovery of triazolone derivatives as novel, potent stearoyl-CoA desaturase-1 (SCD1) inhibitors.
Shaoyi Sun, Zaihui Zhang, Natalia Pokrovskaia, Sultan Chowdhury, Qi Jia, Natalie A Dales

Bioorg Med Chem· February 2015

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Opportunities and challenges in developing stearoyl-coenzyme A desaturase-1 inhibitors as novel therapeutics for human disease.
Zaihui Zhang, Natalie A Dales, Michael D Winther

J Med Chem· June 2014

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Discovery of thiazolylpyridinone SCD1 inhibitors with preferential liver distribution and reduced mechanism-based adverse effects.
Shaoyi Sun, Zaihui Zhang, Vandna Raina, Natalia Pokrovskaia, Duanjie Hou, Natalie Dales

Bioorg Med Chem Lett· January 2014

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Systematic evaluation of amide bioisosteres leading to the discovery of novel and potent thiazolylimidazolidinone inhibitors of SCD1 for the treatment of metabolic diseases.
Shaoyi Sun, Zaihui Zhang, Vishnumurthy Kodumuru, Natalia Pokrovskaia, Julia Fonarev, Natalie A Dales

Bioorg Med Chem Lett· January 2014

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Pharmacological inhibition of stearoyl CoA desaturase in the skin induces atrophy of the sebaceous glands.
Josef G Meingassner, Heinrich Aschauer, Anthony P Winiski, Natalie Dales, David Yowe

J Invest Dermatol· August 2013

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Enzymatic characterization of the pancreatic islet-specific glucose-6-phosphatase-related protein (IGRP).
Anthony J Petrolonis, Qing Yang, Peter J Tummino, Susan M Fish, Andrea E Prack, Natalie A Dales

J Biol Chem· April 2004

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ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
Paul Towler, Bart Staker, Sridhar G Prasad, Saurabh Menon, Jin Tang, Natalie A Dales

J Biol Chem· April 2004

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Substrate-based design of the first class of angiotensin-converting enzyme-related carboxypeptidase (ACE2) inhibitors.
Natalie A Dales, Alexandra E Gould, James A Brown, Emily F Calderwood, Bing Guan

J Am Chem Soc· October 2002

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