Publications by authors named "Nicholas Agard"

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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy.
Pragya Adhikari, Guangmin Li, MaryAnn Go, Danielle Mandikian, Hanine Rafidi, Nicholas Agard

J Am Chem Soc· July 2024

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Potent and selective binders of the E3 ubiquitin ligase ZNRF3 stimulate Wnt signaling and intestinal organoid growth.
Yvonne T Kschonsak, Xinxin Gao, Stephen E Miller, Sunhee Hwang, Hadir Marei, Nicholas J Agard

Cell Chem Biol· June 2024

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Exposing the molecular heterogeneity of glycosylated biotherapeutics.
Luis F Schachner, Christopher Mullen, Wilson Phung, Joshua D Hinkle, Michelle Irwin Beardsley, Nicholas J Agard

Nat Commun· April 2024

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Translatability of Stress for Predicting Deamidation and Oxidation Biotransformation on Biotherapeutics.
Phillip Y Chu, Hui Wang, Emily Ross, Nicole Stephens, Hui-Min Zhang, Nicholas J Agard

Anal Chem· December 2023

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Antibody targeting of E3 ubiquitin ligases for receptor degradation.
Hadir Marei, Wen-Ting K Tsai, Yee-Seir Kee, Karen Ruiz, Jieyan He, Nicholas J Agard

Nature· October 2022

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Development of T-cell engagers selective for cells co-expressing two antigens.
Danielle M Dicara, Sunil Bhakta, Mary Ann Go, James Ziai, Ron Firestein, Nicholas J Agard

MAbs· October 2022

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Direct Tie2 Agonists Stabilize Vasculature for the Treatment of Diabetic Macular Edema.
Nicholas J Agard, Gu Zhang, John Ridgeway, Danielle M Dicara, Phillip Y Chu

Transl Vis Sci Technol· October 2022

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Generation of a Porcine Antibody Fab Fragment Using Protein Engineering to Facilitate the Evaluation of Ocular Sustained Delivery Technology.
Robert F Kelley, Devin B Tesar, Yue Wang, Nicholas J Agard, Patrick G Holder

Mol Pharm· May 2022

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Cleavage of talin by calpain promotes platelet-mediated fibrin clot contraction.
Karen P Fong, Kathleen S Molnar, Nicholas Agard, Rustem I Litvinov, Oleg V Kim

Blood Adv· December 2021

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Preclinical optimization of Ly6E-targeted ADCs for increased durability and efficacy of anti-tumor response.
Josefa Dela Cruz Chuh, MaryAnn Go, Yvonne Chen, Jun Guo, Hanine Rafidi, Nicholas J Agard

MAbs· October 2021

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Targeted IgMs agonize ocular targets with extended vitreal exposure.
Yvonne Chen, Maciej Paluch, Julie A Zorn, Sharmila Rajan, Brandon Leonard, Nicholas J Agard

MAbs· August 2021

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High-throughput screening of antibody variants for chemical stability: identification of deamidation-resistant mutants.
Danielle M DiCara, Nisana Andersen, Ruby Chan, James A Ernst, Gai Ayalon, Nicholas J Agard

MAbs· October 2018

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Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.
Alan M Hyde, Zhijian Liu, Birgit Kosjek, Lushi Tan, Artis Klapars, Nicholas J Agard

Org Lett· November 2016

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Unraveling the mechanism of cell death induced by chemical fibrils.
Olivier Julien, Martin Kampmann, Michael C Bassik, Julie A Zorn, Vincent J Venditto, Nicholas J Agard

Nat Chem Biol· November 2014

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Fibrils colocalize caspase-3 with procaspase-3 to foster maturation.
Julie A Zorn, Dennis W Wolan, Nicholas J Agard, James A Wells

J Biol Chem· September 2012

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Global kinetic analysis of proteolysis via quantitative targeted proteomics.
Nicholas J Agard, Sami Mahrus, Jonathan C Trinidad, Aenoch Lynn, Alma L Burlingame

Proc Natl Acad Sci U S A· February 2012

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Inflammatory stimuli regulate caspase substrate profiles.
Nicholas J Agard, David Maltby, James A Wells

Mol Cell Proteomics· May 2010

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Copper-free click chemistry in living animals.
Pamela V Chang, Jennifer A Prescher, Ellen M Sletten, Jeremy M Baskin, Isaac A Miller, Nicholas J Agard

Proc Natl Acad Sci U S A· February 2010

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Methods for the proteomic identification of protease substrates.
Nicholas J Agard, James A Wells

Curr Opin Chem Biol· December 2009

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Chemical approaches to perturb, profile, and perceive glycans.
Nicholas J Agard, Carolyn R Bertozzi

Acc Chem Res· June 2009

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Second-generation difluorinated cyclooctynes for copper-free click chemistry.
Julian A Codelli, Jeremy M Baskin, Nicholas J Agard, Carolyn R Bertozzi

J Am Chem Soc· August 2008

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Copper-free click chemistry for dynamic in vivo imaging.
Jeremy M Baskin, Jennifer A Prescher, Scott T Laughlin, Nicholas J Agard, Pamela V Chang

Proc Natl Acad Sci U S A· October 2007

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Metabolic labeling of glycans with azido sugars for visualization and glycoproteomics.
Scott T Laughlin, Nicholas J Agard, Jeremy M Baskin, Isaac S Carrico, Pamela V Chang

Methods Enzymol· February 2007

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A comparative study of bioorthogonal reactions with azides.
Nicholas J Agard, Jeremy M Baskin, Jennifer A Prescher, Anderson Lo, Carolyn R Bertozzi

ACS Chem Biol· November 2006

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Discovery of aminoacyl-tRNA synthetase activity through cell-surface display of noncanonical amino acids.
A James Link, Mandy K S Vink, Nicholas J Agard, Jennifer A Prescher, Carolyn R Bertozzi

Proc Natl Acad Sci U S A· July 2006

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