Publications by authors named "Nitin A Patil"

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Identifying Novel Spiro-Indenoquinoxaline-Pyrrolidine-Based Amyloid Beta Inhibitors in Alzheimer's Disease from to .
Shital Rani, Mandeep Kaur, Pritiman Pothal, Kshitij Rajput, Alisha Khera, Nitin Aniruddha Patil

ACS Chem Neurosci· November 2025

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Structure-Activity Relationship of the Diaminobutyric Acid Residues in Polymyxins.
Wendong Ma, Xukai Jiang, Kaijie Mu, Sixin Tian, Heidi H Yu, Nitin A Patil

JACS Au· October 2025

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Exploring Structure-Activity Relationships and Modes of Action of Laterocidine.
Varsha J Thombare, James D Swarbrick, Mohammad A K Azad, Yan Zhu, Jing Lu, Nitin A Patil

ACS Cent Sci· September 2024

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Advancing Nitrile-Aminothiol Strategy for Dual and Sequential Bioconjugation.
Varsha J Thombare, Yimin Wu, Kavya Pamulapati, Meiling Han, Julien Tailhades, Nitin A Patil

Chemistry· August 2024

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Arginine catabolism is essential to polymyxin dependence in Acinetobacter baumannii.
Mei-Ling Han, Yasser Alsaadi, Jinxin Zhao, Yan Zhu, Jing Lu, Nitin A Patil

Cell Rep· July 2024

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Structure-Interaction Relationship of Polymyxins with Lung Surfactant.
Xukai Jiang, Nitin A Patil, Yuwen Xu, Hasini Wickremasinghe, Qi Tony Zhou

J Med Chem· December 2023

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Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity.
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu

J Med Chem· February 2023

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An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant .
Xukai Jiang, Meiling Han, Kevin Tran, Nitin A Patil, Wendong Ma

J Med Chem· July 2022

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A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens.
Kade D Roberts, Yan Zhu, Mohammad A K Azad, Mei-Ling Han, Jiping Wang, Nitin A Patil

Nat Commun· March 2022

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An Efficient Approach for the Design and Synthesis of Antimicrobial Peptide-Peptide Nucleic Acid Conjugates.
Nitin A Patil, Varsha J Thombare, Rong Li, Xiaoji He, Jing Lu

Front Chem· March 2022

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A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening .
Xukai Jiang, Nitin A Patil, Mohammad A K Azad, Hasini Wickremasinghe, Heidi Yu

Chem Sci· September 2021

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2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease.
Nitin A Patil, Jun-Ping Quek, Barbara Schroeder, Richard Morewood, Jörg Rademann

ACS Med Chem Lett· May 2021

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Molecular dynamics simulations informed by membrane lipidomics reveal the structure-interaction relationship of polymyxins with the lipid A-based outer membrane of Acinetobacter baumannii.
Xukai Jiang, Kai Yang, Bing Yuan, Meiling Han, Yan Zhu, Nitin A Patil

J Antimicrob Chemother· December 2020

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Simulations of octapeptin-outer membrane interactions reveal conformational flexibility is linked to antimicrobial potency.
Xukai Jiang, Kai Yang, Bing Yuan, Bin Gong, Lin Wan, Nitin A Patil

J Biol Chem· November 2020

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Polymyxins Bind to the Cell Surface of Unculturable and Cause Unique Dependent Resistance.
Yan Zhu, Jing Lu, Mei-Ling Han, Xukai Jiang, Mohammad A K Azad, Nitin A Patil

Adv Sci (Weinh)· August 2020

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Adsorption of Amyloidogenic Peptides to Functionalized Surfaces Is Biased by Charge and Hydrophilicity.
Torsten John, George W Greene, Nitin A Patil, Tiara J A Dealey, Mohammed A Hossain

Langmuir· November 2019

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The Kinetics of Amyloid Fibrillar Aggregation of Uperin 3.5 Is Directed by the Peptide's Secondary Structure.
Torsten John, Tiara J A Dealey, Nicholas P Gray, Nitin A Patil, Mohammed A Hossain

Biochemistry· September 2019

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Rapid Photolysis-Mediated Folding of Disulfide-Rich Peptides.
Nitin A Patil, John A Karas, John D Wade, Mohammed Akhter Hossain, Julien Tailhades

Chemistry· June 2019

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Thiol-Cyanobenzothiazole Ligation for the Efficient Preparation of Peptide-PNA Conjugates.
Nitin A Patil, John A Karas, Bradley J Turner, Fazel Shabanpoor

Bioconjug Chem· March 2019

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Relaxin family peptides: structure-activity relationship studies.
Nitin A Patil, K Johan Rosengren, Frances Separovic, John D Wade, Ross A D Bathgate

Br J Pharmacol· May 2017

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A One-Pot Chemically Cleavable Bis-Linker Tether Strategy for the Synthesis of Heterodimeric Peptides.
Nitin A Patil, Julien Tailhades, John A Karas, Frances Separovic, John D Wade

Angew Chem Int Ed Engl· November 2016

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Total Chemical Synthesis of an Intra-A-Chain Cystathionine Human Insulin Analogue with Enhanced Thermal Stability.
John A Karas, Nitin A Patil, Julien Tailhades, Marc-Antoine Sani, Denis B Scanlon

Angew Chem Int Ed Engl· November 2016

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A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1.
Mohammed Akhter Hossain, Martina Kocan, Song T Yao, Simon G Royce, Vinojini B Nair, Nitin A Patil

Chem Sci· June 2016

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The C-terminus of the B-chain of human insulin-like peptide 5 is critical for cognate RXFP4 receptor activity.
Nitin A Patil, Ross A D Bathgate, Martina Kocan, Sheng Yu Ang, Julien Tailhades

Amino Acids· April 2016

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Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist.
Nitin A Patil, Richard A Hughes, K Johan Rosengren, Martina Kocan, Sheng Yu Ang

J Med Chem· March 2016

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