Publications by authors named "Pascal Sanchez"

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Pascal E Sanchez

Science· August 2025

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Development of Thin Carbon-Ceramic Based Coatings in Roll-to-Roll Mode: Tribological and Corrosion Results on Stainless Steel.
Mª Fe Menéndez Suárez, Pascal Sanchez, Ana L Martínez Díez, Beatriz Mingo Roman, Marta Mohedano Sánchez

Materials (Basel)· May 2025

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DNL343 is an investigational CNS penetrant eukaryotic initiation factor 2B activator that prevents and reverses the effects of neurodegeneration caused by the integrated stress response.
Ernie Yulyaningsih, Jung H Suh, Melania Fanok, Roni Chau, Hilda Solanoy, Pascal E Sanchez

Elife· September 2024

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Targeting the transferrin receptor to transport antisense oligonucleotides across the mammalian blood-brain barrier.
Scarlett J Barker, Mai B Thayer, Chaeyoung Kim, David Tatarakis, Matthew J Simon, Pascal E Sanchez

Sci Transl Med· August 2024

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Discovery of DNL343: A Potent, Selective, and Brain-Penetrant eIF2B Activator Designed for the Treatment of Neurodegenerative Diseases.
Robert A Craig, Javier De Vicente, Anthony A Estrada, Jianwen A Feng, Katrina W Lexa, Pascal E Sanchez

J Med Chem· April 2024

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Pascal E Sanchez

Cell· March 2024

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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Pascal E Sanchez

Nat Neurosci· March 2023

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H Suh, Pascal E Sanchez

Mol Neurodegener· June 2022

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, Darren Chan, Jason C Dugas, Pascal E Sanchez

J Exp Med· March 2022

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Iduronate-2-sulfatase transport vehicle rescues behavioral and skeletal phenotypes in a mouse model of Hunter syndrome.
Annie Arguello, René Meisner, Elliot R Thomsen, Hoang N Nguyen, Ritesh Ravi, Pascal E Sanchez

JCI Insight· October 2021

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Pascal E Sanchez

Cell· September 2021

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Behavioral and neural network abnormalities in human APP transgenic mice resemble those of App knock-in mice and are modulated by familial Alzheimer's disease mutations but not by inhibition of BACE1.
Erik C B Johnson, Kaitlyn Ho, Gui-Qiu Yu, Melanie Das, Pascal E Sanchez

Mol Neurodegener· September 2020

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Leveraging preclinical models for the development of Alzheimer disease therapeutics.
Kimberly Scearce-Levie, Pascal E Sanchez, Joseph W Lewcock

Nat Rev Drug Discov· July 2020

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Brain delivery and activity of a lysosomal enzyme using a blood-brain barrier transport vehicle in mice.
Julie C Ullman, Annie Arguello, Jennifer A Getz, Akhil Bhalla, Cathal S Mahon, Pascal E Sanchez

Sci Transl Med· May 2020

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Mihalis S Kariolis, Robert C Wells, Jennifer A Getz, Wanda Kwan, Cathal S Mahon, Pascal E Sanchez

Sci Transl Med· May 2020

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TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Pascal E Sanchez

Neuron· March 2020

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Cross-species translation of the Morris maze for Alzheimer's disease.
Katherine L Possin, Pascal E Sanchez, Clifford Anderson-Bergman, Roland Fernandez, Geoffrey A Kerchner

J Clin Invest· February 2016

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Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.
Meaghan Morris, Pascal E Sanchez, Laure Verret, Alexander J Beagle, Weikun Guo

Ann Clin Transl Neurol· November 2015

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Depth profile analysis of amorphous silicon thin film solar cells by pulsed radiofrequency glow discharge time of flight mass spectrometry.
Aitor Alvarez-Toral, Pascal Sanchez, Armando Menéndez, Rosario Pereiro, Alfredo Sanz-Medel

J Am Soc Mass Spectrom· February 2015

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Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice.
Dena B Dubal, Lei Zhu, Pascal E Sanchez, Kurtresha Worden, Lauren Broestl

J Neurosci· February 2015

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Tau reduction prevents disease in a mouse model of Dravet syndrome.
Ania L Gheyara, Ravikumar Ponnusamy, Biljana Djukic, Ryan J Craft, Kaitlyn Ho, Pascal E Sanchez

Ann Neurol· September 2014

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Standardized environmental enrichment supports enhanced brain plasticity in healthy rats and prevents cognitive impairment in epileptic rats.
Raafat P Fares, Amor Belmeguenai, Pascal E Sanchez, Hayet Y Kouchi, Jacques Bodennec

PLoS One· July 2013

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Physiologic brain activity causes DNA double-strand breaks in neurons, with exacerbation by amyloid-β.
Elsa Suberbielle, Pascal E Sanchez, Alexxai V Kravitz, Xin Wang, Kaitlyn Ho

Nat Neurosci· May 2013

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Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model.
Pascal E Sanchez, Lei Zhu, Laure Verret, Keith A Vossel, Anna G Orr

Proc Natl Acad Sci U S A· October 2012

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Endogenous and exogenous hydrogen influence on amorphous silicon thin films analysis by pulsed radiofrequency glow discharge optical emission spectrometry.
Pascal Sánchez, Deborah Alberts, Beatriz Fernández, Armando Menéndez, Rosario Pereiro

Anal Chim Acta· February 2012

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