Publications by authors named "Paula Loria"

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Type I interferon regulation by USP18 is a key vulnerability in cancer.
Veronica Jové, Heather Wheeler, Chiachin Wilson Lee, David R Healy, Kymberly Levine, Paula Loria

iScience· April 2024

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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.
Allyn T Londregan, Karlygash Aitmakhanova, James Bennett, Laura J Byrnes, Daniel P Canterbury, Paula M Loria

J Med Chem· January 2023

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Discovery of Ervogastat (PF-06865571): A Potent and Selective Inhibitor of Diacylglycerol Acyltransferase 2 for the Treatment of Non-alcoholic Steatohepatitis.
Kentaro Futatsugi, Shawn Cabral, Daniel W Kung, Kim Huard, Esther Lee, Paula M Loria

J Med Chem· November 2022

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Molecular basis for the regulation of human glycogen synthase by phosphorylation and glucose-6-phosphate.
Thomas J McCorvie, Paula M Loria, Meihua Tu, Seungil Han, Leela Shrestha

Nat Struct Mol Biol· July 2022

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A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor.
David A Griffith, David J Edmonds, Jean-Philippe Fortin, Amit S Kalgutkar, J Brent Kuzmiski, Paula M Loria

J Med Chem· June 2022

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Modulation of SF3B1 in the pre-mRNA spliceosome induces a RIG-I-dependent type I IFN response.
Aaron Y Chang, Yu Jerry Zhou, Sharanya Iyengar, Piotr W Pobiarzyn, Pavel Tishchenko, Paula M Loria

J Biol Chem· November 2021

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Hit Triage and Validation in Phenotypic Screening: Considerations and Strategies.
Fabien Vincent, Paula M Loria, Andrea D Weston, Claire M Steppan, Regis Doyonnas

Cell Chem Biol· November 2020

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Discovery of Diphenylacetamides as CXCR7 Inhibitors with Novel β-Arrestin Antagonist Activity.
Elnaz Menhaji-Klotz, Jessica Ward, Janice A Brown, Paula M Loria, Carina Tan

ACS Med Chem Lett· June 2020

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Discovery of N-(piperidin-3-yl)-N-(pyridin-2-yl)piperidine/piperazine-1-carboxamides as small molecule inhibitors of PCSK9.
Allyn T Londregan, Gary Aspnes, Chris Limberakis, Paula M Loria, Kim F McClure

Bioorg Med Chem Lett· December 2018

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Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1).
Kevin J Filipski, Matthew F Sammons, Samit K Bhattacharya, Jane Panteleev, Janice A Brown, Paula M Loria

ACS Med Chem Lett· May 2018

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Correction: Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
Nathanael G Lintner, Kim F McClure, Donna Petersen, Allyn T Londregan, David W Piotrowski, Paula M Loria

PLoS Biol· April 2018

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Identification of Morpholino-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-ones as Nonsteroidal Mineralocorticoid Antagonists.
David W Piotrowski, Kentaro Futatsugi, Agustin Casimiro-Garcia, Liuqing Wei, Matthew F Sammons, Paula M Loria

J Med Chem· February 2018

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Liver-Targeted Small-Molecule Inhibitors of Proprotein Convertase Subtilisin/Kexin Type 9 Synthesis.
Kim F McClure, David W Piotrowski, Donna Petersen, Liuqing Wei, Jun Xiao, Paula M Loria

Angew Chem Int Ed Engl· December 2017

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Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA).
Ariamala Gopalsamy, Arjun Narayanan, Shenping Liu, Mihir D Parikh, Robert E Kyne, Paula M Loria

J Med Chem· April 2017

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Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain.
Nathanael G Lintner, Kim F McClure, Donna Petersen, Allyn T Londregan, David W Piotrowski, Paula M Loria

PLoS Biol· March 2017

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Helixconstraints and amino acid substitution in GLP-1 increase cAMP and insulin secretion but not beta-arrestin 2 signaling.
Fabien Plisson, Timothy A Hill, Justin M Mitchell, Huy N Hoang, Aline D de Araujo, Paula M Loria

Eur J Med Chem· February 2017

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A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation.
Donna N Petersen, Julie Hawkins, Wanida Ruangsiriluk, Kimberly A Stevens, Bruce A Maguire, Paula M Loria

Cell Chem Biol· November 2016

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Truncated Glucagon-like Peptide-1 and Exendin-4 α-Conotoxin pl14a Peptide Chimeras Maintain Potency and α-Helicity and Reveal Interactions Vital for cAMP Signaling in Vitro.
Joakim E Swedberg, Christina I Schroeder, Justin M Mitchell, David P Fairlie, David J Edmonds, Paula M Loria

J Biol Chem· July 2016

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Optimization of amide-based EP3 receptor antagonists.
Esther C Y Lee, Kentaro Futatsugi, Joel T Arcari, Kevin Bahnck, Steven B Coffey, Paula M Loria

Bioorg Med Chem Lett· June 2016

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Discovery and characterization of novel inhibitors of the sodium-coupled citrate transporter (NaCT or SLC13A5).
Kim Huard, Janice Brown, Jessica C Jones, Shawn Cabral, Kentaro Futatsugi, Paula Loria

Sci Rep· December 2015

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Discovery of an in Vivo Tool to Establish Proof-of-Concept for MAP4K4-Based Antidiabetic Treatment.
Mark Ammirati, Scott W Bagley, Samit K Bhattacharya, Leonard Buckbinder, Anthony A Carlo, Paula M Loria

ACS Med Chem Lett· November 2015

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Cyclic alpha-conotoxin peptidomimetic chimeras as potent GLP-1R agonists.
Joakim E Swedberg, Christina I Schroeder, Justin M Mitchell, Thomas Durek, David P Fairlie, Paula M Loria

Eur J Med Chem· October 2015

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Developing predictive assays: the phenotypic screening "rule of 3".
Fabien Vincent, Paula Loria, Marko Pregel, Robert Stanton, Linda Kitching

Sci Transl Med· June 2015

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Short Hydrophobic Peptides with Cyclic Constraints Are Potent Glucagon-like Peptide-1 Receptor (GLP-1R) Agonists.
Huy N Hoang, Kun Song, Timothy A Hill, David R Derksen, David J Edmonds, Paula M Loria

J Med Chem· May 2015

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Evaluation and synthesis of polar aryl- and heteroaryl spiroazetidine-piperidine acetamides as ghrelin inverse agonists.
Suvi T M Orr, Ramsay Beveridge, Samit K Bhattacharya, Kimberly O Cameron, Steven Coffey, Paula M Loria

ACS Med Chem Lett· February 2015

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