Publications by authors named "Peer Jacobson"

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Neutralizing RGMa with Elezanumab Promotes Cerebroprotection and Recovery in Rabbit Middle Cerebral Artery Occlusion.
Peer B Jacobson, Andrea Mothe, Aharon Levy, Michael Krakovsky, Bradley A Hooker

Transl Stroke Res· August 2024

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Delayed administration of elezanumab, a human anti-RGMa neutralizing monoclonal antibody, promotes recovery following cervical spinal cord injury.
Andrea J Mothe, Peer B Jacobson, Mitchell Caprelli, Antigona Ulndreaj, Radmehr Rahemipour

Neurobiol Dis· October 2022

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Intrathecal amyloid-beta oligomer administration increases tau phosphorylation in the medial temporal lobe in the African green monkey: A nonhuman primate model of Alzheimer's disease.
Dustin R Wakeman, Michael R Weed, Sylvia E Perez, Erika N Cline, Kirsten L Viola, Peer B Jacobson

Neuropathol Appl Neurobiol· June 2022

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Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates.
Peer B Jacobson, Robin Goody, Matthew Lawrence, Bernhard K Mueller, Xiaomeng Zhang

Neurobiol Dis· July 2021

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Delayed administration of the human anti-RGMa monoclonal antibody elezanumab promotes functional recovery including spontaneous voiding after spinal cord injury in rats.
Andrea J Mothe, Marlon Coelho, Lili Huang, Philippe P Monnier, Yi-Fang Cui, Peer B Jacobson

Neurobiol Dis· September 2020

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The Vasopressin 1b Receptor Antagonist A-988315 Blocks Stress Effects on the Retrieval of Object-Recognition Memory.
Areg Barsegyan, Piray Atsak, Wilfried B Hornberger, Peer B Jacobson, Marcel M van Gaalen

Neuropsychopharmacology· July 2015

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Effect of analgesic therapy on clinical outcome measures in a randomized controlled trial using client-owned dogs with hip osteoarthritis.
Sarah Malek, Susannah J Sample, Zeev Schwartz, Brett Nemke, Peer B Jacobson

BMC Vet Res· October 2012

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Differential effects of domoic acid and E. coli lipopolysaccharide on tumor necrosis factor-alpha, transforming growth factor-beta1 and matrix metalloproteinase-9 release by rat neonatal microglia: evaluation of the direct activation hypothesis.
Alejandro M S Mayer, Marcio Guzman, Renee Peksa, Mary Hall, Michael J Fay, Peer B Jacobson

Mar Drugs· September 2012

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Estimating efficacy and drug ED50's using von Frey thresholds: impact of weber's law and log transformation.
Charles Mills, David Leblond, Shailen Joshi, Chang Zhu, Gin Hsieh, Peer Jacobson

J Pain· June 2012

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Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats.
Chang Z Zhu, Chih-Liang Chin, Nathan R Rustay, Chengmin Zhong, Joe Mikusa, Peer B Jacobson

Biochem Pharmacol· October 2011

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Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition.
Eric G Mohler, Kaitlin E Browman, Victoria A Roderwald, Elizabeth A Cronin, Stella Markosyan, Peer B Jacobson

J Neurosci· April 2011

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Effect of 11 beta-hydroxysteroid dehydrogenase-1 inhibition on hepatic glucose metabolism in the conscious dog.
Dale S Edgerton, Rita Basu, Christopher J Ramnanan, Tiffany D Farmer, Doss Neal, Peer Jacobson

Am J Physiol Endocrinol Metab· May 2010

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Liver is the site of splanchnic cortisol production in obese nondiabetic humans.
Rita Basu, Ananda Basu, Meagan Grudzien, Paul Jung, Peer Jacobson

Diabetes· January 2009

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Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice.
Ruojing Yang, Denise M Wilcox, Deanna L Haasch, Paul M Jung, Phong T Nguyen, Peer B Jacobson

J Biol Chem· August 2007

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Hepatic knockdown of stearoyl-CoA desaturase 1 via RNA interference in obese mice decreases lipid content and changes fatty acid composition.
Haiyan Xu, Denise Wilcox, Phong Nguyen, Martin Voorbach, Harriet Smith, Peer B Jacobson

Front Biosci· May 2007

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Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance.
Bradley Zinker, Amanda Mika, Phong Nguyen, Denise Wilcox, Lars Ohman, Peer Jacobson

Metabolism· March 2007

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Discovery of adamantane ethers as inhibitors of 11beta-HSD-1: Synthesis and biological evaluation.
Jyoti R Patel, Qi Shuai, Jurgen Dinges, Marty Winn, Marina Pliushchev, Peer Jacobson

Bioorg Med Chem Lett· February 2007

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Adamantane sulfone and sulfonamide 11-beta-HSD1 Inhibitors.
Bryan Sorensen, Martin Winn, Jeff Rohde, Qi Shuai, Jiahong Wang, Peer Jacobson

Bioorg Med Chem Lett· January 2007

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Parallel strategies for the preparation and selection of liver-targeted glucocorticoid receptor antagonists.
Bradley J Backes, Gregory L Hamilton, Phong Nguyen, Denise Wilcox, Steven Fung, Peer B Jacobson

Bioorg Med Chem Lett· January 2007

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Discovery and metabolic stabilization of potent and selective 2-amino-N-(adamant-2-yl) acetamide 11beta-hydroxysteroid dehydrogenase type 1 inhibitors.
Jeffrey J Rohde, Marina A Pliushchev, Bryan K Sorensen, Dariusz Wodka, Qi Shuai, Peer B Jacobson

J Med Chem· January 2007

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Synthesis and activity of novel bile-acid conjugated glucocorticoid receptor antagonists.
Steven J Richards, Thomas W von Geldern, Peer Jacobson, Denise Wilcox, Phong Nguyen

Bioorg Med Chem Lett· December 2006

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Adamantane 11-beta-HSD-1 inhibitors: Application of an isocyanide multicomponent reaction.
Bryan Sorensen, Jeff Rohde, Jiahong Wang, Steven Fung, Katina Monzon, Peer Jacobson

Bioorg Med Chem Lett· December 2006

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Discovery of potent and selective inhibitors of 11beta-HSD1 for the treatment of metabolic syndrome.
Steven Richards, Bryan Sorensen, Hwan-Soo Jae, Marty Winn, Yixian Chen, Peer Jacobson

Bioorg Med Chem Lett· December 2006

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Discovery of orally active butyrolactam 11beta-HSD1 inhibitors.
Vince S C Yeh, Ravi Kurukulasuriya, Steven Fung, Katina Monzon, William Chiou, Peer Jacobson

Bioorg Med Chem Lett· November 2006

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Hepatic knockdown of mitochondrial GPAT1 in ob/ob mice improves metabolic profile.
Haiyan Xu, Denise Wilcox, Phong Nguyen, Martin Voorbach, Thomas Suhar, Peer B Jacobson

Biochem Biophys Res Commun· October 2006

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