Publications by authors named "Peter B Simpson"

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Advanced molecular imaging for the characterisation of complex medicines.
Duygu Yilmaz, Paul S Sharp, Martin J Main, Peter B Simpson

Drug Discov Today· June 2022

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IMI European Lead Factory - democratizing access to high-throughput screening.
Philip S Jones, Sylviane Boucharens, Stuart P McElroy, Angus Morrison, Saman Honarnejad, Peter B Simpson

Nat Rev Drug Discov· April 2022

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Ultrasound-triggered therapeutic microbubbles enhance the efficacy of cytotoxic drugs by increasing circulation and tumor drug accumulation and limiting bioavailability and toxicity in normal tissues.
Nicola Ingram, Laura E McVeigh, Radwa H Abou-Saleh, Juliana Maynard, Sally A Peyman, Peter B Simpson

Theranostics· May 2021

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What makes a drug discovery consortium successful?
Peter B Simpson, Graeme F Wilkinson

Nat Rev Drug Discov· November 2020

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Organ-on-a-chip technology: turning its potential for clinical benefit into reality.
Malcolm Haddrick, Peter B Simpson

Drug Discov Today· May 2019

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Open innovation in early drug discovery: roadmaps and roadblocks.
Melvin Reichman, Peter B Simpson

Drug Discov Today· May 2016

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Opening the lead generation toolbox.
Peter B Simpson, Melvin Reichman

Nat Rev Drug Discov· January 2014

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Enzymatic characterisation of USP7 deubiquitinating activity and inhibition.
Jonathan D Wrigley, Kay Eckersley, Ian M Hardern, Lindsey Millard, Michael Walters, Peter B Simpson

Cell Biochem Biophys· June 2011

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Methacholine and PDGF activate store-operated calcium entry in neuronal precursor cells via distinct calcium entry channels.
Paul Cuddon, Martin D Bootman, Gillian R Richards, Alison J Smith, Peter B Simpson

Biol Res· August 2009

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The discovery of AZD5597, a potent imidazole pyrimidine amide CDK inhibitor suitable for intravenous dosing.
Clifford D Jones, David M Andrews, Andrew J Barker, Kevin Blades, Paula Daunt, Peter B Simpson

Bioorg Med Chem Lett· December 2008

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High-content assays in oncology drug discovery: opportunities and challenges.
Elizabeth H Mouchet, Peter B Simpson

IDrugs· June 2008

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Measurement and analysis of calcium signaling in heterogeneous cell cultures.
Gillian R Richards, Andrew D Jack, Amy Platts, Peter B Simpson

Methods Enzymol· December 2006

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Automated cell plating and sample treatments for fixed cells in high content assays.
Gillian R Richards, Julie E Kerby, Grace K Y Chan, Peter B Simpson

Methods Mol Biol· November 2006

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A morphology- and kinetics-based cascade for human neural cell high content screening.
Gillian R Richards, Alison J Smith, Frances Parry, Amy Platts, Grace K Y Chan, Peter B Simpson

Assay Drug Dev Technol· April 2006

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New directions in kinetic high information content assays.
Peter B Simpson, Keith A Wafford

Drug Discov Today· March 2006

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High content kinetic assays of neuronal signaling implemented on BD pathway HT.
Grace K Y Chan, Gillian R Richards, Marco Peters, Peter B Simpson

Assay Drug Dev Technol· December 2005

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A new pyridazine series of GABAA alpha5 ligands.
Monique B van Niel, Kevin Wilson, Charles H Adkins, John R Atack, José L Castro, Peter B Simpson

J Med Chem· September 2005

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A high-throughput assay for modulators of ligand-gated chloride channels.
Michel Hamelin, Xin Meng, Michael Cuddy, Keith Korsun, John Ondeyka, Peter B Simpson

Assay Drug Dev Technol· February 2005

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Compounds exhibiting selective efficacy for different beta subunits of human recombinant gamma-aminobutyric acid A receptors.
Alison J Smith, Beth Oxley, Sallie Malpas, Gopalan V Pillai, Peter B Simpson

J Pharmacol Exp Ther· November 2004

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Quantitative assays of chemotaxis and chemokinesis for human neural cells.
Gillian R Richards, Rachel M Millard, Mathew Leveridge, Julie Kerby, Peter B Simpson

Assay Drug Dev Technol· October 2004

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Multiple structural features of steroids mediate subtype-selective effects on human alpha4beta3delta GABAA receptors.
Gopalan V Pillai, Alison J Smith, Peter A Hunt, Peter B Simpson

Biochem Pharmacol· September 2004

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Methodological approaches for the study of GABA(A) receptor pharmacology and functional responses.
Alison J Smith, Peter B Simpson

Anal Bioanal Chem· November 2003

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Characterisation of a sphingosine 1-phosphate-activated Ca2+ signalling pathway in human neuroblastoma cells.
Israel Ramos Villullas, Alison J Smith, Robert P Heavens, Peter B Simpson

J Neurosci Res· July 2003

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Native and recombinant human Edg4 receptor-mediated Ca(2+) signalling.
Peter B Simpson, Israel Ramos Villullas, Irina Schurov, Julie Kerby, Rachel Millard

Assay Drug Dev Technol· November 2002

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Estrogen receptor ligands affect mitochondrial activity in SH-SY5Y human neuroblastoma cells.
Peter B Simpson, Anthony J Woollacott, Zahid Moneer, Vikki Rand, Guy R Seabrook

Neuroreport· May 2002

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