Publications by authors named "Peter M Finan"

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Potent, Selective, and Orally Bioavailable Inhibitors of VPS34 Provide Chemical Tools to Modulate Autophagy in Vivo.
Ayako Honda, Edmund Harrington, Ivan Cornella-Taracido, Pascal Furet, Mark S Knapp, Peter M Finan

ACS Med Chem Lett· January 2016

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Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo.
William E Dowdle, Beat Nyfeler, Jane Nagel, Robert A Elling, Shanming Liu, Peter M Finan

Nat Cell Biol· November 2014

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Target identification for a Hedgehog pathway inhibitor reveals the receptor GPR39.
Frederic Bassilana, Adam Carlson, Jennifer A DaSilva, Bianka Grosshans, Solange Vidal, Peter M Finan

Nat Chem Biol· May 2014

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PIKfyve, a class III PI kinase, is the target of the small molecular IL-12/IL-23 inhibitor apilimod and a player in Toll-like receptor signaling.
Xinming Cai, Yongyao Xu, Atwood K Cheung, Ronald C Tomlinson, Abel Alcázar-Román, Peter M Finan

Chem Biol· July 2013

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RAD001 enhances the potency of BEZ235 to inhibit mTOR signaling and tumor growth.
Beat Nyfeler, Yan Chen, Xiaoyan Li, Maria Pinzon-Ortiz, Zuncai Wang, Peter M Finan

PLoS One· May 2013

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Defective autophagy and mTORC1 signaling in myotubularin null mice.
Kristina M Fetalvero, Yenyen Yu, Margaret Goetschkes, Guiqing Liang, Reginald A Valdez, Peter M Finan

Mol Cell Biol· January 2013

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Genetic ablation of PI3Kγ results in defective IL-17RA signalling in T lymphocytes and increased IL-17 levels.
Stephanie J Harris, Loredana Ciuclan, Peter M Finan, Matthias P Wymann, Christoph Walker

Eur J Immunol· December 2012

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Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.
Fred Harbinski, Vanessa J Craig, Sneha Sanghavi, Douglas Jeffery, Lijuan Liu, Peter M Finan

Cancer Discov· October 2012

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TBC1D7 is a third subunit of the TSC1-TSC2 complex upstream of mTORC1.
Christian C Dibble, Winfried Elis, Suchithra Menon, Wei Qin, Justin Klekota, Peter M Finan

Mol Cell· August 2012

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ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner.
Huai-Xiang Hao, Yang Xie, Yue Zhang, Olga Charlat, Emma Oster, Peter M Finan

Nature· April 2012

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Relieving autophagy and 4EBP1 from rapamycin resistance.
Beat Nyfeler, Philip Bergman, Ellen Triantafellow, Christopher J Wilson, Yanyi Zhu, Peter M Finan

Mol Cell Biol· July 2011

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RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling.
Yue Zhang, Shanming Liu, Craig Mickanin, Yan Feng, Olga Charlat, Peter M Finan

Nat Cell Biol· May 2011

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COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.
Cory M Johannessen, Jesse S Boehm, So Young Kim, Sapana R Thomas, Leslie Wardwell, Peter M Finan

Nature· December 2010

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Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies.
Seth A Ettenberg, Olga Charlat, Michael P Daley, Shanming Liu, Karen J Vincent, Peter M Finan

Proc Natl Acad Sci U S A· August 2010

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Activation of a metabolic gene regulatory network downstream of mTOR complex 1.
Katrin Düvel, Jessica L Yecies, Suchithra Menon, Pichai Raman, Alex I Lipovsky, Peter M Finan

Mol Cell· July 2010

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Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling.
Shih-Min A Huang, Yuji M Mishina, Shanming Liu, Atwood Cheung, Frank Stegmeier, Peter M Finan

Nature· October 2009

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Bidirectional transport of amino acids regulates mTOR and autophagy.
Paul Nicklin, Philip Bergman, Bailin Zhang, Ellen Triantafellow, Henry Wang, Peter M Finan

Cell· February 2009

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Down-regulation of class II phosphoinositide 3-kinase alpha expression below a critical threshold induces apoptotic cell death.
Winfried Elis, Ellen Triantafellow, Natalie M Wolters, Katie R Sian, Giordano Caponigro, Peter M Finan

Mol Cancer Res· April 2008

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