Publications by authors named "Peter MacKenzie"

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UDP-glucuronosyltransferase 1A9 function is mediated by the two C-terminal lysine residues and proper mobility/flexibility of the cytoplasmic tail.
Yuu Miyauchi, Yume Sadato, Madoka Sawai, Shinji Takechi, Masahiro Hiratsuka, Peter I Mackenzie

Biochem Biophys Res Commun· January 2026

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Racial disparities in child welfare: A propensity score matched analysis of Black and White children in Canada.
Alicia Boatswain-Kyte, Kofi Antwi-Boasiako, Philip Baiden, Nico Trocmé, Barbara Fallon, Peter Mackenzie

Child Abuse Negl· November 2025

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Disulfide bond-mediated stabilization of the oligomers of UDP-glucuronosyltransferase 2B7.
Yuu Miyauchi, Haruna Koba, Madoka Sawai, Hisao Kansui, Shinji Takechi, Peter I Mackenzie

J Biol Chem· September 2025

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Sex-specific UGT expression and function: prevalence, potential mechanisms and significance.
Robyn Meech, Dong Gui Hu, Julie-Ann Hulin, Peter I Mackenzie

Expert Opin Drug Metab Toxicol· May 2025

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Activation of Cryptic Donor Splice Sites within the UDP-Glucuronosyltransferase (UGT)1A First-Exon Region Generates Variant Transcripts That Encode UGT1A Proteins with Truncated Aglycone-Binding Domains.
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Radwan Ansaar, Peter I Mackenzie

Drug Metab Dispos· May 2024

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Examining the role of child welfare worker characteristics and the substantiation decision.
Kristen Lwin, Alex Hoagland, Kofi Antwi-Boasiako, Peter MacKenzie, Barbara Fallon

Child Abuse Negl· March 2024

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A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers.
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A McKinnon, Peter I Mackenzie

Cancers (Basel)· January 2024

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The Somatic Mutation Landscape of UDP-Glycosyltransferase () Genes in Human Cancers.
Dong Gui Hu, Shashikanth Marri, Julie-Ann Hulin, Ross A McKinnon, Peter I Mackenzie

Cancers (Basel)· November 2022

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Regulation of human UDP-glycosyltransferase () genes by miRNAs.
Dong Gui Hu, Peter I Mackenzie, Julie-Ann Hulin, Ross A McKinnon, Robyn Meech

Drug Metab Rev· May 2022

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Use of a Baculovirus-Mammalian Cell Expression-System for Expression of Drug-Metabolizing Enzymes: Optimization of Infection With a Focus on Cytochrome P450 3A4.
Yuu Miyauchi, Akane Kimura, Madoka Sawai, Keiko Fujimoto, Yuko Hirota, Peter I Mackenzie

Front Pharmacol· February 2022

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The Expression Profiles and Deregulation of UDP-Glycosyltransferase () Genes in Human Cancers and Their Association with Clinical Outcomes.
Dong Gui Hu, Shashikanth Marri, Peter I Mackenzie, Julie-Ann Hulin, Ross A McKinnon

Cancers (Basel)· September 2021

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Circular RNAs of UDP-Glycosyltransferase () Genes Expand the Complexity and Diversity of the UGT Transcriptome.
Dong Gui Hu, Peter I Mackenzie, Julie-Ann Hulin, Ross A McKinnon, Robyn Meech

Mol Pharmacol· June 2021

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The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.
Dong Gui Hu, Peter I Mackenzie, Pramod C Nair, Ross A McKinnon, Robyn Meech

Cancers (Basel)· November 2020

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The carboxyl-terminal di-lysine motif is essential for catalytic activity of UDP-glucuronosyltransferase 1A9.
Yuu Miyauchi, Ken Kurohara, Akane Kimura, Madoka Esaki, Keiko Fujimoto, Peter I Mackenzie

Drug Metab Pharmacokinet· October 2020

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Coexpression of Human Hepatic Uridine Diphosphate Glucuronosyltransferase Proteins: Implications for Ontogenetic Mechanisms and Isoform Coregulation.
Yuejian Liu, Justine Badée, Ryan H Takahashi, Stephan Schmidt, Neil Parrott, Peter I Mackenzie

J Clin Pharmacol· June 2020

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Hetero-oligomer formation of mouse UDP-glucuronosyltransferase (UGT) 2b1 and 1a1 results in the gain of glucuronidation activity towards morphine, an activity which is absent in homo-oligomers of either UGT.
Yuu Miyauchi, Ayumi Kurita, Ryohei Yamashita, Tomoyuki Takamatsu, Shin'ichi Ikushiro, Peter I Mackenzie

Biochem Biophys Res Commun· April 2020

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UDP-Glucuronosyltransferase (UGT)-mediated attenuations of cytochrome P450 3A4 activity: UGT isoform-dependent mechanism of suppression.
Yuu Miyauchi, Yoshitaka Tanaka, Kiyoshi Nagata, Yasushi Yamazoe, Peter I Mackenzie

Br J Pharmacol· March 2020

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The UGTome: The expanding diversity of UDP glycosyltransferases and its impact on small molecule metabolism.
Dong Gui Hu, J Ulie-Ann Hulin, Pramod C Nair, Alex Z Haines, Ross A McKinnon, Peter I Mackenzie

Pharmacol Ther· December 2019

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Investigation of the Endoplasmic Reticulum Localization of UDP-Glucuronosyltransferase 2B7 with Systematic Deletion Mutants.
Yuu Miyauchi, Sora Kimura, Akane Kimura, Ken Kurohara, Yuko Hirota, Peter I Mackenzie

Mol Pharmacol· May 2019

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The UDP-Glycosyltransferase (UGT) Superfamily: New Members, New Functions, and Novel Paradigms.
Robyn Meech, Dong Gui Hu, Ross A McKinnon, Siti Nurul Mubarokah, Alex Z Haines, Peter I Mackenzie

Physiol Rev· April 2019

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Drug and Chemical Glucosidation by Control Supersomes and Membranes from (Sf) 9 Cells: Implications for the Apparent Glucuronidation of Xenobiotics by UDP-glucuronosyltransferase 1A5.
Nuy Chau, Leyla Kaya, Benjamin C Lewis, Peter I Mackenzie, John O Miners

Drug Metab Dispos· March 2019

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Deregulation of the Genes that Are Involved in Drug Absorption, Distribution, Metabolism, and Excretion in Hepatocellular Carcinoma.
Dong Gui Hu, Shashikanth Marri, Ross A McKinnon, Peter I Mackenzie, Robyn Meech

J Pharmacol Exp Ther· March 2019

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Plasma extracellular nanovesicle (exosome)-derived biomarkers for drug metabolism pathways: a novel approach to characterize variability in drug exposure.
Andrew Rowland, Warit Ruanglertboon, Madelé van Dyk, Dhilushi Wijayakumara, Linda S Wood, Peter I Mackenzie

Br J Clin Pharmacol· January 2019

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Intergenic Splicing between Four Adjacent Genes () Gives Rise to Variant UGT Proteins That Inhibit Glucuronidation via Protein-Protein Interactions.
Dong Gui Hu, Julie-Ann Hulin, Dhilushi D Wijayakumara, Ross A McKinnon, Peter I Mackenzie

Mol Pharmacol· September 2018

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Cooperative Regulation of Intestinal UDP-Glucuronosyltransferases 1A8, -1A9, and 1A10 by CDX2 and HNF4 Is Mediated by a Novel Composite Regulatory Element.
Nurul Mubarokah, Julie-Ann Hulin, Peter I Mackenzie, Ross A McKinnon, Alex Z Haines

Mol Pharmacol· May 2018

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