Publications by authors named "Peter McNamara"

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The role of organisational- and country-level factors in the volume and public visibility of business and management research.
Kevin Credit, Olga Ryazanova, Peter McNamara

PLoS One· June 2024

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A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877.
Yahu A Liu, Qihui Jin, Qiang Ding, Xueshi Hao, Tingting Mo, Peter McNamara

ChemMedChem· August 2020

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Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells.
Hans E Hohmeier, Lu Zhang, Brandon Taylor, Samuel Stephens, Danhong Lu, Peter McNamara

PLoS One· May 2020

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Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis.
Donatella Chianelli, Paul V Rucker, Jason Roland, David C Tully, John Nelson, Peter McNamara

J Med Chem· April 2020

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Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
Yahu A Liu, Qihui Jin, Yefen Zou, Qiang Ding, Shanshan Yan, Peter McNamara

J Med Chem· March 2020

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Tropifexor-Mediated Abrogation of Steatohepatitis and Fibrosis Is Associated With the Antioxidative Gene Expression Profile in Rodents.
Eloy D Hernandez, Lianxing Zheng, Young Kim, Bin Fang, Bo Liu, Peter McNamara

Hepatol Commun· August 2019

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Structure-guided combination therapy to potently improve the function of mutant CFTRs.
Guido Veit, Haijin Xu, Elise Dreano, Radu G Avramescu, Miklos Bagdany, Peter McNamara

Nat Med· November 2018

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Guide Swap enables genome-scale pooled CRISPR-Cas9 screening in human primary cells.
Pamela Y Ting, Albert E Parker, J Scott Lee, Chris Trussell, Orzala Sharif, Peter McNamara

Nat Methods· November 2018

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Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH).
David C Tully, Paul V Rucker, Donatella Chianelli, Jennifer Williams, Agnès Vidal, Peter McNamara

J Med Chem· December 2017

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EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor.
Yong Jia, Jose Juarez, Jie Li, Mari Manuia, Matthew J Niederst, Peter McNamara

Cancer Res· March 2016

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Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.
Weijun Shen, Brandon Taylor, Qihui Jin, Van Nguyen-Tran, Shelly Meeusen, Peter McNamara

Nat Commun· October 2015

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IL-2 immunotherapy reveals potential for innate beta cell regeneration in the non-obese diabetic mouse model of autoimmune diabetes.
Yaiza Diaz-de-Durana, Janet Lau, Deborah Knee, Christophe Filippi, Marco Londei, Peter McNamara

PLoS One· February 2015

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Novel tricyclic pyrazolopyrimidines as potent and selective GPR119 agonists.
Mihai Azimioara, Phil Alper, Christopher Cow, Daniel Mutnick, Victor Nikulin, Peter McNamara

Bioorg Med Chem Lett· December 2014

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The ALK inhibitor ceritinib overcomes crizotinib resistance in non-small cell lung cancer.
Luc Friboulet, Nanxin Li, Ryohei Katayama, Christian C Lee, Justin F Gainor, Peter McNamara

Cancer Discov· June 2014

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Discovery of structurally novel, potent and orally efficacious GPR119 agonists.
Phil Alper, Mihai Azimioara, Christopher Cow, Daniel Mutnick, Victor Nikulin, Peter McNamara

Bioorg Med Chem Lett· May 2014

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Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.
Dean P Phillips, Wenqi Gao, Yang Yang, Guobao Zhang, Isabelle K Lerario, Peter McNamara

J Med Chem· April 2014

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Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974.
Jun Liu, Shifeng Pan, Mindy H Hsieh, Nicholas Ng, Fangxian Sun, Peter McNamara

Proc Natl Acad Sci U S A· December 2013

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Small-molecule inducer of β cell proliferation identified by high-throughput screening.
Weijun Shen, Matthew S Tremblay, Vishal A Deshmukh, Weidong Wang, Christophe M Filippi, Peter McNamara

J Am Chem Soc· February 2013

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Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.
Laura H Jacobson, S Renee Commerford, Sarah P Gerber, Yu Alice Chen, Beatriz Dardik, Peter McNamara

Naunyn Schmiedebergs Arch Pharmacol· December 2011

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Surfactants, aromatic and isoprenoid compounds, and fatty acid biosynthesis inhibitors suppress Staphylococcus aureus production of toxic shock syndrome toxin 1.
Peter J McNamara, Rae Ellen Syverson, Kathy Milligan-Myhre, Olga Frolova, Sarah Schroeder

Antimicrob Agents Chemother· May 2009

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A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus.
Christian Kohler, Christof von Eiff, Manuel Liebeke, Peter J McNamara, Michael Lalk

J Bacteriol· October 2008

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In vitro susceptibility of Staphylococcus aureus to thrombin-induced platelet microbicidal protein-1 (tPMP-1) is influenced by cell membrane phospholipid composition and asymmetry.
Kasturi Mukhopadhyay, William Whitmire, Yan Q Xiong, Jaime Molden, Tiffanny Jones, Peter J McNamara

Microbiology (Reading)· April 2007

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A role for Alström syndrome protein, alms1, in kidney ciliogenesis and cellular quiescence.
Guochun Li, Raquel Vega, Keats Nelms, Nicholas Gekakis, Christopher Goodnow, Peter McNamara

PLoS Genet· January 2007

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Bacterial interactions and the microevolution of cytochrome bd: implications for pathogenesis.
Peter J McNamara, Richard A Proctor

J Bacteriol· December 2006

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Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotype.
Jochen Seggewiss, Karsten Becker, Oliver Kotte, Martin Eisenacher, Mohammad Reza Khoschkhoi Yazdi, Peter McNamara

J Bacteriol· November 2006

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