Publications by authors named "Philip Lograsso"

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Identification of a highly neurotoxic α-synuclein species inducing mitochondrial damage and mitophagy in Parkinson's disease.
Diego Grassi, Shannon Howard, Minghai Zhou, Natalia Diaz-Perez, Nicolai T Urban, Philip LoGrasso

Proc Natl Acad Sci U S A· March 2018

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Pharmacological Inhibition of c-Jun N-terminal Kinase Reduces Food Intake and Sensitizes Leptin's Anorectic Signaling Actions.
Su Gao, Shannon Howard, Philip V LoGrasso

Sci Rep· February 2017

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Correction to Design and Synthesis of Highly Potent and Isoform Selective JNK3 Inhibitors: SAR Studies on Aminopyrazole Derivatives.
Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V LoGrasso

J Med Chem· October 2016

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Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential.
Yangbo Feng, Philip V LoGrasso, Olivier Defert, Rongshi Li

J Med Chem· March 2016

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Serum- and Glucocorticoid-Inducible Kinase 1 Confers Protection in Cell-Based and in In Vivo Neurotoxin Models via the c-Jun N-Terminal Kinase Signaling Pathway.
Sarah Iqbal, Shannon Howard, Philip V LoGrasso

Mol Cell Biol· June 2015

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Pyridopyrimidinone Derivatives as Potent and Selective c-Jun N-Terminal Kinase (JNK) Inhibitors.
Ke Zheng, Chul Min Park, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V LoGrasso

ACS Med Chem Lett· April 2015

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Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.
Yan Yin, Ke Zheng, Nibal Eid, Shannon Howard, Ji-Hak Jeong, Philip V LoGrasso

J Med Chem· February 2015

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Structural basis and biological consequences for JNK2/3 isoform selective aminopyrazoles.
HaJeung Park, Sarah Iqbal, Pamela Hernandez, Rudy Mora, Ke Zheng, Philip LoGrasso

Sci Rep· January 2015

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Design and synthesis of highly potent and isoform selective JNK3 inhibitors: SAR studies on aminopyrazole derivatives.
Ke Zheng, Sarah Iqbal, Pamela Hernandez, HaJeung Park, Philip V LoGrasso

J Med Chem· December 2014

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Rho kinase inhibitors: a patent review (2012 - 2013).
Yangbo Feng, Philip V LoGrasso

Expert Opin Ther Pat· March 2014

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Synthesis and SAR of novel isoxazoles as potent c-jun N-terminal kinase (JNK) inhibitors.
Yuanjun He, Derek Duckett, Weimin Chen, Yuan Yuan Ling, Michael D Cameron, Philip V Lograsso

Bioorg Med Chem Lett· January 2014

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A small molecule bidentate-binding dual inhibitor probe of the LRRK2 and JNK kinases.
Yangbo Feng, Jeremy W Chambers, Sarah Iqbal, Marcel Koenig, HaJeung Park, Philip V LoGrasso

ACS Chem Biol· August 2013

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Synthesis and biological evaluation of urea derivatives as highly potent and selective rho kinase inhibitors.
Yan Yin, Li Lin, Claudia Ruiz, Susan Khan, Michael D Cameron, Philip V Lograsso

J Med Chem· May 2013

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Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid.
Valer Jeso, Sarah Iqbal, Pamela Hernandez, Michael D Cameron, HaJeung Park, Philip V LoGrasso

Angew Chem Int Ed Engl· April 2013

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Amino acid derived quinazolines as Rock/PKA inhibitors.
Sarwat Chowdhury, Yen Ting Chen, Xingang Fang, Wayne Grant, Jennifer Pocas, Philip V Lograsso

Bioorg Med Chem Lett· March 2013

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Inhibition of JNK mitochondrial localization and signaling is protective against ischemia/reperfusion injury in rats.
Jeremy W Chambers, Alok Pachori, Shannon Howard, Sarah Iqbal, Philip V LoGrasso

J Biol Chem· February 2013

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Blocking c-Jun N-terminal kinase (JNK) translocation to the mitochondria prevents 6-hydroxydopamine-induced toxicity in vitro and in vivo.
Jeremy W Chambers, Shannon Howard, Philip V LoGrasso

J Biol Chem· January 2013

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Structural mechanisms of allostery and autoinhibition in JNK family kinases.
John D Laughlin, Jerome C Nwachukwu, Mariana Figuera-Losada, Lisa Cherry, Kendall W Nettles, Philip V LoGrasso

Structure· December 2012

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Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: implications for long-term culture expansion.
Siddaraju V Boregowda, Veena Krishnappa, Jeremy W Chambers, Philip V Lograsso, Wen-Tzu Lai

Stem Cells· May 2012

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Enzyme kinetics and interaction studies for human JNK1β1 and substrates activating transcription factor 2 (ATF2) and c-Jun N-terminal kinase (c-Jun).
Mariana Figuera-Losada, Philip V LoGrasso

J Biol Chem· April 2012

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Discovery of potent and selective covalent inhibitors of JNK.
Tinghu Zhang, Francisco Inesta-Vaquera, Mario Niepel, Jianming Zhang, Scott B Ficarro, Philip V LoGrasso

Chem Biol· January 2012

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Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I).
Sarwat Chowdhury, E Hampton Sessions, Jennifer R Pocas, Wayne Grant, Thomas Schröter, Philip LoGrasso

Bioorg Med Chem Lett· December 2011

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Discovery and optimization of indole and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-II).
E Hampton Sessions, Sarwat Chowdhury, Yan Yin, Jennifer R Pocas, Wayne Grant, Philip LoGrasso

Bioorg Med Chem Lett· December 2011

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Convergent synthesis and discovery of a natural product-inspired paralog-selective Hsp90 inhibitor.
Valer Jeso, Lisa Cherry, Todd K Macklin, Subhas Chandra Pan, Philip V LoGrasso

Org Lett· October 2011

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Small Molecule c-jun-N-terminal Kinase (JNK) Inhibitors Protect Dopaminergic Neurons in a Model of Parkinson's Disease.
Jeremy W Chambers, Alok Pachori, Shannon Howard, Michelle Ganno, Donald Hansen, Philip Lograsso

ACS Chem Neurosci· April 2011

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