Publications by authors named "Philip Simister"

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A Polyproline Type II Peptidomimetic Disrupts a Grb2 SH3C Domain Protein-Protein Interaction Implicated in Breast Cancer.
James Luccarelli, Philip C Simister, Andrew D Hamilton, Stephan M Feller, Sam Thompson

Chembiochem· July 2025

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Structural insights into engineering a T-cell receptor targeting MAGE-A10 with higher affinity and specificity for cancer immunotherapy.
Philip C Simister, Ellen C Border, João F Vieira, Nicholas J Pumphrey

J Immunother Cancer· July 2022

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A novel FRET peptide assay reveals efficient Helicobacter pylori HtrA inhibition through zinc and copper binding.
Sabine Bernegger, Cyrill Brunner, Matej Vizovišek, Marko Fonovic, Gaetano Cuciniello, Philip Simister

Sci Rep· June 2020

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Differential Recognition Preferences of the Three Src Homology 3 (SH3) Domains from the Adaptor CD2-associated Protein (CD2AP) and Direct Association with Ras and Rab Interactor 3 (RIN3).
Evgenia Rouka, Philip C Simister, Melanie Janning, Joerg Kumbrink, Tassos Konstantinou

J Biol Chem· October 2015

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MAPK-induced Gab1 translocation to the plasma membrane depends on a regulated intramolecular switch.
Alexandra Wolf, René Eulenfeld, Hannes Bongartz, Wiebke Hessenkemper, Philip C Simister

Cell Signal· February 2015

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A THEMIS:SHP1 complex promotes T-cell survival.
Wolfgang Paster, Annika M Bruger, Kristin Katsch, Claude Grégoire, Romain Roncagalli, Philip C Simister

EMBO J· February 2015

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Inhibiting HtrA protease by addressing a computationally predicted allosteric ligand binding site.
Anna Maria Perna, Felix Reisen, Thomas P Schmidt, Tim Geppert, Max Pillong, Philip C Simister

Chem Sci· June 2014

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Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide.
Seiichi Sato, Yingshe Zhao, Misa Imai, Philip C Simister, Stephan M Feller

PLoS One· May 2014

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Conformational recognition of an intrinsically disordered protein.
James M Krieger, Giuliana Fusco, Marc Lewitzky, Philip C Simister, Jan Marchant

Biophys J· April 2014

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Novel inhibitors of a Grb2 SH3C domain interaction identified by a virtual screen.
Philip C Simister, James Luccarelli, Sam Thompson, Daniel H Appella, Stephan M Feller

Bioorg Med Chem· July 2013

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GRB2-mediated recruitment of THEMIS to LAT is essential for thymocyte development.
Wolfgang Paster, Claudia Brockmeyer, Guo Fu, Philip C Simister, Ben de Wet

J Immunol· April 2013

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Beyond 'furballs' and 'dumpling soups' - towards a molecular architecture of signaling complexes and networks.
Marc Lewitzky, Philip C Simister, Stephan M Feller

FEBS Lett· August 2012

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Application of ring-closing metathesis to Grb2 SH3 domain-binding peptides.
Fa Liu, Alessio Giubellino, Philip C Simister, Wenjian Qian, Michael C Giano

Biopolymers· February 2012

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Order and disorder in large multi-site docking proteins of the Gab family--implications for signalling complex formation and inhibitor design strategies.
Philip C Simister, Stephan M Feller

Mol Biosyst· January 2012

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An objective assessment of conformational variability in complexes of hepatitis C virus polymerase with non-nucleoside inhibitors.
Célia Caillet-Saguy, Philip C Simister, Stéphane Bressanelli

J Mol Biol· December 2011

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A comprehensive structure-function comparison of hepatitis C virus strain JFH1 and J6 polymerases reveals a key residue stimulating replication in cell culture across genotypes.
Melanie Schmitt, Nathalie Scrima, Danijela Radujkovic, Célia Caillet-Saguy, Philip C Simister

J Virol· March 2011

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Self-organization and regulation of intrinsically disordered proteins with folded N-termini.
Philip C Simister, Fred Schaper, Nicola O'Reilly, Simon McGowan, Stephan M Feller

PLoS Biol· February 2011

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Further insights into the roles of GTP and the C terminus of the hepatitis C virus polymerase in the initiation of RNA synthesis.
Déborah Harrus, Neveen Ahmed-El-Sayed, Philip C Simister, Steve Miller, Martine Triconnet

J Biol Chem· October 2010

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Structural and functional analysis of hepatitis C virus strain JFH1 polymerase.
Philip Simister, Melanie Schmitt, Matthis Geitmann, Oliver Wicht, U Helena Danielson

J Virol· November 2009

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Distinct binding modes of two epitopes in Gab2 that interact with the SH3C domain of Grb2.
Maria Harkiolaki, Theodora Tsirka, Marc Lewitzky, Philip C Simister, Dhira Joshi

Structure· June 2009

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Interactions between conserved domains within homodimers in the BIG1, BIG2, and GBF1 Arf guanine nucleotide exchange factors.
Odile Ramaen, Alexandra Joubert, Philip Simister, Naïma Belgareh-Touzé, Maria Conception Olivares-Sanchez

J Biol Chem· September 2007

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