Publications by authors named "Phillip Sharp"

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Engineered prime editors with minimal genomic errors.
Vikash P Chauhan, Phillip A Sharp, Robert Langer

Nature· October 2025

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Mutant p53 exploits enhancers to elevate immunosuppressive chemokine expression and impair immune checkpoint inhibitors in pancreatic cancer.
Dig B Mahat, Heena Kumra, Sarah A Castro, Emily Metcalf, Kim Nguyen, Phillip A Sharp

Immunity· July 2025

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RNA Dynamics Regulate Transcriptional Condensate Vivacity to Drive Gene Coordination.
Koichi Ogami, Ming M Zheng, Seiko Yoshino, Yohei Sugimoto, Mayu Seida, Phillip A Sharp

bioRxiv· June 2025

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The future of open research policy should be evidence based.
Phillip A Sharp, William B Bonvillian, Amy Brand, David Goldston, Michael Stebbins

Proc Natl Acad Sci U S A· August 2024

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Engineered prime editors with minimal genomic errors.
Vikash P Chauhan, Phillip A Sharp, Robert Langer

bioRxiv· August 2024

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Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic Cancer.
Dig B Mahat, Heena Kumra, Sarah A Castro, Emily Metcalf, Kim Nguyen, Phillip A Sharp

bioRxiv· August 2024

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Single-cell nascent RNA sequencing unveils coordinated global transcription.
Dig B Mahat, Nathaniel D Tippens, Jorge D Martin-Rufino, Sean K Waterton, Jiayu Fu, Phillip A Sharp

Nature· July 2024

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Author Correction: CIS is a potent checkpoint in NK cell-mediated tumor immunity.
Rebecca B Delconte, Tatiana B Kolesnik, Laura F Dagley, Jai Rautela, Wei Shi, Phillip P Sharp

Nat Immunol· February 2024

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Improved modeling of RNA-binding protein motifs in an interpretable neural model of RNA splicing.
Kavi Gupta, Chenxi Yang, Kayla McCue, Osbert Bastani, Phillip A Sharp

Genome Biol· January 2024

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Correction for Song et al., "Sustained Small Interfering RNA-Mediated Human Immunodeficiency Virus Type 1 Inhibition in Primary Macrophages".
Erwei Song, Sang-Kyung Lee, Derek M Dykxhoorn, Carl Novina, Dong Zhang, Phillip A Sharp

J Virol· October 2023

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Signal peptide mimicry primes Sec61 for client-selective inhibition.
Shahid Rehan, Dale Tranter, Phillip P Sharp, Gregory B Craven, Eric Lowe

Nat Chem Biol· September 2023

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Single-cell nascent RNA sequencing using click-chemistry unveils coordinated transcription.
Dig B Mahat, Nathaniel D Tippens, Jorge D Martin-Rufino, Sean K Waterton, Jiayu Fu, Phillip A Sharp

bioRxiv· September 2023

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Oncogenic mutations impede nuclear RNA surveillance.
Megan L Insco, Brian J Abraham, Sara J Dubbury, Ines H Kaltheuner, Sofia Dust, Phillip A Sharp

Science· April 2023

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Altered DNA repair pathway engagement by engineered CRISPR-Cas9 nucleases.
Vikash P Chauhan, Phillip A Sharp, Robert Langer

Proc Natl Acad Sci U S A· March 2023

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Transcription factor antagonism regulates heterogeneity in embryonic stem cell states.
Sofia Hu, Emily Metcalf, Dig Bijay Mahat, Lynette Chan, Noor Sohal, Phillip A Sharp

Mol Cell· December 2022

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Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.
Lauren K Meyer, Cristina Delgado-Martin, Phillip P Sharp, Benjamin J Huang, Dustin McMinn

Br J Haematol· July 2022

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RNA in formation and regulation of transcriptional condensates.
Phillip A Sharp, Arup K Chakraborty, Jonathan E Henninger, Richard A Young

RNA· January 2022

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Inhibitors of Eukaryotic Translational Machinery as Therapeutic Agents.
Angela Fan, Phillip P Sharp

J Med Chem· March 2021

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Clarity on the crackdown.
Harvey Lodish, Jianzhu Chen, Phillip Sharp

Science· February 2021

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RNA-Mediated Feedback Control of Transcriptional Condensates.
Jonathan E Henninger, Ozgur Oksuz, Krishna Shrinivas, Ido Sagi, Gary LeRoy, Phillip A Sharp

Cell· January 2021

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Partitioning of cancer therapeutics in nuclear condensates.
Isaac A Klein, Ann Boija, Lena K Afeyan, Susana Wilson Hawken, Mengyang Fan, Phillip A Sharp

Science· June 2020

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Imprinted Maternally Expressed microRNAs Antagonize Paternally Driven Gene Programs in Neurons.
Amanda J Whipple, Vincent Breton-Provencher, Hannah N Jacobs, Udbhav K Chitta, Mriganka Sur, Phillip A Sharp

Mol Cell· April 2020

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MicroRNAs organize intrinsic variation into stem cell states.
Meenakshi Chakraborty, Sofia Hu, Erica Visness, Marco Del Giudice, Andrea De Martino, Phillip A Sharp

Proc Natl Acad Sci U S A· March 2020

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A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.
David E Gordon, Gwendolyn M Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Phillip P Sharp

bioRxiv· March 2020

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