Publications by authors named "Pradeep Pallan"

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A first-in-class EGFR-directed KRAS G12V selective inhibitor.
Lyla J Stanland, Hayden P Huggins, Snehasudha S Sahoo, Alessandro Porrello, Yogitha Chareddy, Pradeep S Pallan

Cancer Cell· October 2025

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Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.
Krishna C Aluri, Dhrubajyoti Datta, Scott Waldron, Nate Taneja, June Qin, Pradeep S Pallan

J Am Chem Soc· October 2024

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Prolinyl Phosphoramidates of Nucleotides with Increased Reactivity.
Adrian Humboldt, Fabian Rami, Franka M Topp, Dejana Arnold, Daniela Göhringer, Pradeep S Pallan

Angew Chem Int Ed Engl· April 2024

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Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Pradeep S Pallan, Terry P Lybrand, Eriks Rozners, Mikhail Abramov, Guy Schepers

Biochemistry· October 2023

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The peroxidation-derived DNA adduct, 6-oxo-MdG, is a strong block to replication by human DNA polymerase η.
Robyn Richie-Jannetta, Pradeep Pallan, Philip J Kingsley, Nikhil Kamdar, Martin Egli

J Biol Chem· August 2023

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Conformation and Pairing Properties of an -Methyl-2'-deoxyguanosine-Directed Benzimidazole Nucleoside Analog in Duplex DNA.
Andrew H Kellum, Pradeep S Pallan, Arman Nilforoushan, Shana J Sturla, Michael P Stone

Chem Res Toxicol· October 2022

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Cryo neutron crystallography demonstrates influence of RNA 2'-OH orientation on conformation, sugar pucker and water structure.
Joel M Harp, Terry P Lybrand, Pradeep S Pallan, Leighton Coates, Brendan Sullivan

Nucleic Acids Res· July 2022

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Silencing of Oncogenic KRAS by Mutant-Selective Small Interfering RNA.
Bjoern Papke, Salma H Azam, Anne Y Feng, Christina Gutierrez-Ford, Hayden Huggins, Pradeep S Pallan

ACS Pharmacol Transl Sci· April 2021

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Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Pradeep S Pallan, Terry P Lybrand, Mark K Schlegel, Joel M Harp, Hartmut Jahns

Biochemistry· December 2020

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The Enzyme-Free Release of Nucleotides from Phosphoramidates Depends Strongly on the Amino Acid.
Dejana Jovanovic, Peter Tremmel, Pradeep S Pallan, Martin Egli, Clemens Richert

Angew Chem Int Ed Engl· November 2020

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Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5'-(R)- and 5'-(S)-C-methyl-guanosine.
Atsushi Mikami, Namrata Erande, Shigeo Matsuda, Alexander Kel'in, Lauren Blair Woods, Pradeep S Pallan

Nucleic Acids Res· October 2020

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Comparative analysis of inosine-substituted duplex DNA by circular dichroism and X-ray crystallography.
Justin P Peters, Ewa A Kowal, Pradeep S Pallan, Martin Egli, L James Maher

J Biomol Struct Dyn· August 2018

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Inherent steroid 17α,20-lyase activity in defunct cytochrome P450 17A enzymes.
Eric Gonzalez, Kevin M Johnson, Pradeep S Pallan, Thanh T N Phan, Wei Zhang

J Biol Chem· January 2018

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Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Daniel Mutisya, Travis Hardcastle, Samwel K Cheruiyot, Pradeep S Pallan, Scott D Kennedy

Nucleic Acids Res· August 2017

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Functional analysis of human cytochrome P450 21A2 variants involved in congenital adrenal hyperplasia.
Chunxue Wang, Pradeep S Pallan, Wei Zhang, Li Lei, Francis K Yoshimoto

J Biol Chem· June 2017

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Chirality Dependent Potency Enhancement and Structural Impact of Glycol Nucleic Acid Modification on siRNA.
Mark K Schlegel, Donald J Foster, Alexander V Kel'in, Ivan Zlatev, Anna Bisbe, Pradeep S Pallan

J Am Chem Soc· June 2017

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Evoking picomolar binding in RNA by a single phosphorodithioate linkage.
N Dinuka Abeydeera, Martin Egli, Nehemiah Cox, Karen Mercier, Jonas Nascimento Conde, Pradeep S Pallan

Nucleic Acids Res· September 2016

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Limits of RNA 2'-OH Mimicry by Fluorine: Crystal Structure of Bacillus halodurans RNase H Bound to a 2'-FRNA:DNA Hybrid.
Pradeep S Pallan, Thazha P Prakash, Arnie R de Leon, Martin Egli

Biochemistry· September 2016

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Generating Crystallographic Models of DNA Dodecamers from Structures of RNase H:DNA Complexes.
Martin Egli, Pradeep S Pallan

Methods Mol Biol· May 2016

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Research Resource: Correlating Human Cytochrome P450 21A2 Crystal Structure and Phenotypes of Mutations in Congenital Adrenal Hyperplasia.
Pradeep S Pallan, Li Lei, Chunxue Wang, Michael R Waterman, F Peter Guengerich

Mol Endocrinol· September 2015

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Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYME·PROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
Pradeep S Pallan, Chunxue Wang, Li Lei, Francis K Yoshimoto, Richard J Auchus

J Biol Chem· May 2015

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Correction to differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Marta W Szulik, Pradeep S Pallan, Boguslaw Nocek, Markus Voehler, Surajit Banerjee

Biochemistry· April 2015

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Structural and kinetic basis of steroid 17α,20-lyase activity in teleost fish cytochrome P450 17A1 and its absence in cytochrome P450 17A2.
Pradeep S Pallan, Leslie D Nagy, Li Lei, Eric Gonzalez, Valerie M Kramlinger

J Biol Chem· February 2015

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Differential stabilities and sequence-dependent base pair opening dynamics of Watson-Crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine.
Marta W Szulik, Pradeep S Pallan, Boguslaw Nocek, Markus Voehler, Surajit Banerjee

Biochemistry· February 2015

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Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Daniel Mutisya, Chelliah Selvam, Benjamin D Lunstad, Pradeep S Pallan, Amanda Haas

Nucleic Acids Res· June 2014

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