Publications by authors named "Rachel Uren"

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Computational design of potent and selective binders of BAK and BAX.
Stephanie Berger, Erinna F Lee, Tiffany J Harris, Sharon Tran, Asim K Bera, Lauren Arguinchona, Rachel T Uren

Sci Adv· September 2025

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A lipid signature of BAK-driven apoptotic pore formation.
Rachel T Uren, Matthew E Ritchie, Agnes W Wong, Justin P Ludeman, Etsuko Uno

bioRxiv· November 2024

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Sequence differences between BAX and BAK core domains manifest as differences in their interactions with lipids.
Michelle S Miller, Angus D Cowan, Jason M Brouwer, Sean T Smyth, Liuyu Peng, Rachel T Uren

FEBS J· June 2024

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A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.
Hema Preethi Subas Satish, Sweta Iyer, Melissa X Shi, Agnes W Wong, Karla C Fischer, Rachel T Uren

Cell Death Differ· June 2024

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The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK.
Francine S Ke, Steven Holloway, Rachel T Uren, Agnes W Wong, Melissa H Little

EMBO J· August 2022

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NAb-seq: an accurate, rapid, and cost-effective method for antibody long-read sequencing in hybridoma cell lines and single B cells.
Hema Preethi Subas Satish, Kathleen Zeglinski, Rachel T Uren, Stephen L Nutt, Matthew E Ritchie

MAbs· August 2022

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Structure of detergent-activated BAK dimers derived from the inert monomer.
Richard W Birkinshaw, Sweta Iyer, Daisy Lio, Cindy S Luo, Jason M Brouwer, Rachel T Uren

Mol Cell· May 2021

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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.
Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno

Cell Death Dis· April 2020

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Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.
Sweta Iyer, Rachel T Uren, Ruth M Kluck

Methods Mol Biol· May 2019

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Avoiding adsorption of Bcl-2 proteins to plasticware is important for accurate quantitation.
Colin Hockings, Sweta Iyer, Rachel T Uren, Ruth M Kluck

Cell Death Differ· May 2019

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Pore formation by dimeric Bak and Bax: an unusual pore?
Rachel T Uren, Sweta Iyer, Ruth M Kluck

Philos Trans R Soc Lond B Biol Sci· August 2017

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Disordered clusters of Bak dimers rupture mitochondria during apoptosis.
Rachel T Uren, Martin O'Hely, Sweta Iyer, Ray Bartolo, Melissa X Shi

Elife· February 2017

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Bak core and latch domains separate during activation, and freed core domains form symmetric homodimers.
Jason M Brouwer, Dana Westphal, Grant Dewson, Adeline Y Robin, Rachel T Uren

Mol Cell· September 2014

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Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.
Rachel T Uren, Ann M Turnley

Front Mol Neurosci· June 2014

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A novel role of suppressor of cytokine signaling-2 in the regulation of TrkA neurotrophin receptor biology.
Rachel T Uren, Alisa Turbić, Agnes W Wong, Reuben Klein, Simon S Murray

J Neurochem· May 2014

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Targeted tandem affinity purification of PSD-95 recovers core postsynaptic complexes and schizophrenia susceptibility proteins.
Esperanza Fernández, Mark O Collins, Rachel T Uren, Maksym V Kopanitsa, Noboru H Komiyama

Mol Syst Biol· July 2009

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Neurotransmitters drive combinatorial multistate postsynaptic density networks.
Marcelo P Coba, Andrew J Pocklington, Mark O Collins, Maksym V Kopanitsa, Rachel T Uren

Sci Signal· April 2009

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Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.
Rachel T Uren, Grant Dewson, Lin Chen, Stephanie C Coyne, David C S Huang

J Cell Biol· April 2007

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Mitochondrial release of pro-apoptotic proteins: electrostatic interactions can hold cytochrome c but not Smac/DIABLO to mitochondrial membranes.
Rachel T Uren, Grant Dewson, Christine Bonzon, Trevor Lithgow, Donald D Newmeyer

J Biol Chem· January 2005

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Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling.
Christopher J Greenhalgh, Donald Metcalf, Anne L Thaus, Jason E Corbin, Rachel Uren

J Biol Chem· October 2002

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SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.
Danielle L Krebs, Rachel T Uren, Donald Metcalf, Steven Rakar, Jian-Guo Zhang

Mol Cell Biol· July 2002

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