Publications by authors named "Rob Howes"

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Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Dinesh Aggarwal, Ben Warne, Aminu S Jahun, William L Hamilton, Thomas Fieldman, Rob Howes

Nat Commun· February 2022

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Heat inactivation of clinical COVID-19 samples on an industrial scale for low risk and efficient high-throughput qRT-PCR diagnostic testing.
Oona Delpuech, Julie A Douthwaite, Thomas Hill, Dhevahi Niranjan, Nancy T Malintan, Rob Howes

Sci Rep· February 2022

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Improving the efficiency and effectiveness of an industrial SARS-CoV-2 diagnostic facility.
Julie A Douthwaite, Christopher A Brown, John R Ferdinand, Rahul Sharma, Jane Elliott, Rob Howes

Sci Rep· February 2022

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Single-dose BNT162b2 vaccine protects against asymptomatic SARS-CoV-2 infection.
Nick K Jones, Lucy Rivett, Shaun Seaman, Richard J Samworth, Ben Warne, Rob Howes

Elife· April 2021

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Application of High-Throughput Flow Cytometry in Early Drug Discovery: An AstraZeneca Perspective.
Mei Ding, Roger Clark, Catherine Bardelle, Anna Backmark, Tyrrell Norris, Rob Howes

SLAS Discov· August 2018

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Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists.
Jacqueline Naylor, Arthur T Suckow, Asha Seth, David J Baker, Isabelle Sermadiras, Rob Howes

Biochem J· September 2016

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Isolation of Potent CGRP Neutralizing Antibodies Using Four Simple Assays.
Frances Neal, Joanne Arnold, Christine J Rossant, Sadhana Podichetty, David Lowne, Rob Howes

J Biomol Screen· January 2016

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Genome engineering using Adeno-Associated Virus (AAV).
Rob Howes, Christine Schofield

Methods Mol Biol· July 2015

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JBS special issue on therapeutic antibody discovery and development: biologics come of age.
Joseph G McGivern, Rob Howes

J Biomol Screen· April 2015

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Isocitrate dehydrogenase (IDH) mutations promote a reversible ZEB1/microRNA (miR)-200-dependent epithelial-mesenchymal transition (EMT).
Alexandra R Grassian, Fallon Lin, Rosemary Barrett, Yue Liu, Wei Jiang, Rob Howes

J Biol Chem· December 2012

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Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity.
Alba T Macias, Douglas S Williamson, Nicola Allen, Jenifer Borgognoni, Alexandra Clay, Rob Howes

J Med Chem· June 2011

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Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design.
Douglas S Williamson, Jenifer Borgognoni, Alexandra Clay, Zoe Daniels, Pawel Dokurno, Rob Howes

J Med Chem· March 2009

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NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis.
Suzanne A Eccles, Andy Massey, Florence I Raynaud, Swee Y Sharp, Gary Box, Rob Howes

Cancer Res· April 2008

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Discovery of a potent CDK2 inhibitor with a novel binding mode, using virtual screening and initial, structure-guided lead scoping.
Christine M Richardson, Claire L Nunns, Douglas S Williamson, Martin J Parratt, Pawel Dokurno, Rob Howes

Bioorg Med Chem Lett· July 2007

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Identification of chemically diverse Chk1 inhibitors by receptor-based virtual screening.
Nicolas Foloppe, Lisa M Fisher, Rob Howes, Andrew Potter, Alan G S Robertson

Bioorg Med Chem· July 2006

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Identification of a buried pocket for potent and selective inhibition of Chk1: prediction and verification.
Nicolas Foloppe, Lisa M Fisher, Geraint Francis, Rob Howes, Peter Kierstan

Bioorg Med Chem· March 2006

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Triazolo[1,5-a]pyrimidines as novel CDK2 inhibitors: protein structure-guided design and SAR.
Christine M Richardson, Douglas S Williamson, Martin J Parratt, Jenifer Borgognoni, Andrew D Cansfield, Rob Howes

Bioorg Med Chem Lett· March 2006

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Genetic evidence that Drosophila frizzled controls planar cell polarity and Armadillo signaling by a common mechanism.
Michael Povelones, Rob Howes, Matt Fish, Roel Nusse

Genetics· December 2005

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Structure-based design of novel Chk1 inhibitors: insights into hydrogen bonding and protein-ligand affinity.
Nicolas Foloppe, Lisa M Fisher, Rob Howes, Peter Kierstan, Andrew Potter

J Med Chem· June 2005

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Structure-guided design of pyrazolo[1,5-a]pyrimidines as inhibitors of human cyclin-dependent kinase 2.
Douglas S Williamson, Martin J Parratt, Justin F Bower, Jonathan D Moore, Christine M Richardson, Rob Howes

Bioorg Med Chem Lett· February 2005

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A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site.
Nicolas Foloppe, I-Jen Chen, Ben Davis, Adam Hold, Dave Morley, Rob Howes

Bioorg Med Chem· March 2004

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