Publications by authors named "Rob Wallis"

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Evaluating Associations Between Nonclinical Cardiovascular Functional Endpoints and Repeat-dose Cardiovascular Toxicity in the Beagle Dog: A Cross-company Initiative.
Philip Milliken, Mike Aylott, Nick Edmunds, Steven Engle, Lorna Ewart, Rob Wallis

Toxicol Sci· July 2020

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The cardiac work-loop technique: An in vitro model for identifying and profiling drug-induced changes in inotropy using rat papillary muscles.
Sophie Fletcher, Helen Maddock, Rob S James, Rob Wallis, Mayel Gharanei

Sci Rep· March 2020

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Incidence of spontaneous arrhythmias in freely moving healthy untreated Sprague-Dawley rats.
Paula Juliana Seadi Pereira, Michael K Pugsley, Eric Troncy, Wendy Tan, Mylene Pouliot, Rob Wallis

J Pharmacol Toxicol Methods· May 2019

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CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion.
Rob Wallis, Charles Benson, Borje Darpo, Gary Gintant, Yasunari Kanda

J Pharmacol Toxicol Methods· January 2019

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Predictivity of in vitro non-clinical cardiac contractility assays for inotropic effects in humans--A literature search.
Rob Wallis, Mayel Gharanei, Helen Maddock

J Pharmacol Toxicol Methods· July 2016

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The concordance between nonclinical and phase I clinical cardiovascular assessment from a cross-company data sharing initiative.
Lorna Ewart, Mike Aylott, Mark Deurinck, Mike Engwall, David J Gallacher, Rob Wallis

Toxicol Sci· December 2014

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How do the top 12 pharmaceutical companies operate safety pharmacology?
Lorna Ewart, David J Gallacher, Gary Gintant, Jean-Michel Guillon, Derek Leishman, Rob Wallis

J Pharmacol Toxicol Methods· September 2012

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Predicting the emetic liability of novel chemical entities: a comparative study.
Nathalie Percie du Sert, Anthony M Holmes, Rob Wallis, Paul Lr Andrews

Br J Pharmacol· March 2012

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Safety pharmacology in 2010 and beyond: survey of significant events of the past 10 years and a roadmap to the immediate-, intermediate- and long-term future in recognition of the tenth anniversary of the Safety Pharmacology Society.
Alan S Bass, Hugo M Vargas, Jean-Pierre Valentin, Lewis B Kinter, Tim Hammond, Rob Wallis

J Pharmacol Toxicol Methods· February 2012

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Structural and micro-anatomical changes in vertebrae associated with idiopathic-type spinal curvature in the curveback guppy model.
Kristen F Gorman, Gregory R Handrigan, Ge Jin, Rob Wallis, Felix Breden

Scoliosis· June 2010

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A framework to assess the translation of safety pharmacology data to humans.
Jean-Pierre Valentin, Russell Bialecki, Lorna Ewart, Tim Hammond, Derek Leishmann, Rob Wallis

J Pharmacol Toxicol Methods· December 2009

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Zebrafish assays as early safety pharmacology screens: paradigm shift or red herring?
William S Redfern, Gareth Waldron, Matthew J Winter, Paul Butler, Mark Holbrook, Rob Wallis

J Pharmacol Toxicol Methods· January 2009

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Impact of study design on proarrhythmia prediction in the SCREENIT rabbit isolated heart model.
Jill V Steidl-Nichols, Gilles Hanton, Joanne Leaney, Ruei-Che Liu, Derek Leishman, Rob Wallis

J Pharmacol Toxicol Methods· October 2008

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A pharmacokinetic-pharmacodynamic model for the quantitative prediction of dofetilide clinical QT prolongation from human ether-a-go-go-related gene current inhibition data.
Daniël M Jonker, Leslie A Kenna, Derek Leishman, Rob Wallis, Peter A Milligan

Clin Pharmacol Ther· June 2005

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