Publications by authors named "Ruth Palmer"

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Spatial transcriptomics exploration of the primary neuroblastoma microenvironment in archived FFPE samples unveils novel paracrine interactions.
Joachim T Siaw, Peter Merseburger, Marcus Borenäs, Caroline Jansson, Jenny Karlsson, Ruth H Palmer

J Pathol· October 2025

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Occurrence of cancer in Marfan syndrome: Report of two patients with neuroblastoma and review of the literature.
Carolina Maya-González, Angelica Maria Delgado-Vega, Fulya Taylan, Kristina Lagerstedt Robinson, Lina Hansson, Ruth Palmer

Am J Med Genet A· December 2024

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Long-Lasting Response to Lorlatinib in Patients with ALK-Driven Relapsed or Refractory Neuroblastoma Monitored with Circulating Tumor DNA Analysis.
Torben Ek, Raghda R Ibrahim, Hartmut Vogt, Kleopatra Georgantzi, Catarina Träger, Ruth H Palmer

Cancer Res Commun· September 2024

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Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth.
Wei-Yun Lai, Tzu-Po Chuang, Marcus Borenäs, Dan E Lind, Bengt Hallberg, Ruth H Palmer

Cell Death Differ· July 2024

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The Alk receptor tyrosine kinase regulates Sparkly, a novel activity regulating neuropeptide precursor in the central nervous system.
Sanjay Kumar Sukumar, Vimala Antonydhason, Linnea Molander, Jawdat Sandakly, Malak Kleit, Ruth H Palmer

Elife· June 2024

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Preclinical exploration of the DNA damage response pathway using the interactive neuroblastoma cell line explorer CLEAN.
Jonatan L Gabre, Peter Merseburger, Arne Claeys, Joachim Siaw, Sarah-Lee Bekaert, Ruth H Palmer

NAR Cancer· March 2024

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ALK signaling primes the DNA damage response sensitizing ALK-driven neuroblastoma to therapeutic ATR inhibition.
Marcus Borenäs, Ganesh Umapathy, Dan E Lind, Wei-Yun Lai, Jikui Guan, Ruth H Palmer

Proc Natl Acad Sci U S A· January 2024

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ALK F1174S mutation impairs ALK kinase activity in EML4-ALK variant 1 and sensitizes EML4-ALK variant 3 to crizotinib.
Jikui Guan, Tzu-Po Chuang, Anders Vikström, Ruth H Palmer, Bengt Hallberg

Front Oncol· January 2024

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IGF1R Contributes to Cell Proliferation in -Mutated Neuroblastoma with Preference for Activating the PI3K-AKT Signaling Pathway.
Jikui Guan, Marcus Borenäs, Junfeng Xiong, Wei-Yun Lai, Ruth H Palmer

Cancers (Basel)· August 2023

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ALK fusion NSCLC oncogenes promote survival and inhibit NK cell responses via expression.
Tzu-Po Chuang, Wei-Yun Lai, Jonatan L Gabre, Dan E Lind, Ganesh Umapathy, Ruth H Palmer

Proc Natl Acad Sci U S A· February 2023

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Patient-associated mutations in Drosophila Alk perturb neuronal differentiation and promote survival.
Kathrin Pfeifer, Georg Wolfstetter, Vimala Anthonydhason, Tafheem Masudi, Badrul Arefin, Ruth H Palmer

Dis Model Mech· August 2022

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Characterization of Endogenous Protein Interactomes in Larval Brain, Using a CRISPR/Cas9-based Strategy and BioID-based Proximity Labeling.
Ezgi Uçkun, Georg Wolfstetter, Johannes Fuchs, Ruth H Palmer

Bio Protoc· July 2022

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The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer.
Martina Mazzeschi, Michela Sgarzi, Donatella Romaniello, Valerio Gelfo, Carola Cavallo, Ruth Palmer

J Exp Clin Cancer Res· March 2022

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Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation.
Diana Treis, Ganesh Umapathy, Susanne Fransson, Jikui Guan, Patricia Mendoza-García, Ruth H Palmer

JCO Precis Oncol· January 2022

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DamID transcriptional profiling identifies the Snail/Scratch transcription factor Kahuli as an Alk target in the Drosophila visceral mesoderm.
Patricia Mendoza-Garcia, Swaraj Basu, Sanjay Kumar Sukumar, Badrul Arefin, Georg Wolfstetter, Ruth H Palmer

Development· December 2021

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Mapping the Phospho-dependent ALK Interactome to Identify Novel Components in ALK Signaling.
Farzaneh Aboualizadeh, Zhong Yao, Jikui Guan, Luka Drecun, Shivanthy Pathmanathan, Ruth Palmer

J Mol Biol· November 2021

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In vivo Profiling of the Alk Proximitome in the Developing Drosophila Brain.
Ezgi Uçkun, Georg Wolfstetter, Vimala Anthonydhason, Sanjay Kumar Sukumar, Ganesh Umapathy, Ruth H Palmer

J Mol Biol· November 2021

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ATR inhibition enables complete tumour regression in ALK-driven NB mouse models.
Joanna Szydzik, Dan E Lind, Badrul Arefin, Yeshwant Kurhe, Ganesh Umapathy, Ruth H Palmer

Nat Commun· November 2021

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Chromosome Imbalances in Neuroblastoma-Recent Molecular Insight into Chromosome 1p-deletion, 2p-gain, and 11q-deletion Identifies New Friends and Foes for the Future.
Jikui Guan, Bengt Hallberg, Ruth H Palmer

Cancers (Basel)· November 2021

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BioID-Screening Identifies PEAK1 and SHP2 as Components of the ALK Proximitome in Neuroblastoma Cells.
Ezgi Uçkun, Joachim T Siaw, Jikui Guan, Vimala Anthonydhason, Johannes Fuchs, Ruth H Palmer

J Mol Biol· September 2021

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Neuroblastoma xenograft models demonstrate the therapeutic potential of Lu-octreotate.
Arman Romiani, Johan Spetz, Emman Shubbar, Dan E Lind, Bengt Hallberg, Ruth H Palmer

BMC Cancer· August 2021

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Extracellular domain shedding of the ALK receptor mediates neuroblastoma cell migration.
Hao Huang, Alexander Gont, Lynn Kee, Ruben Dries, Kathrin Pfeifer, Ruth H Palmer

Cell Rep· July 2021

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Loss of RET Promotes Mesenchymal Identity in Neuroblastoma Cells.
Joachim T Siaw, Jonatan L Gabre, Ezgi Uçkun, Marc Vigny, Wancun Zhang, Ruth H Palmer

Cancers (Basel)· April 2021

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ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Marcus Borenäs, Ganesh Umapathy, Wei-Yun Lai, Dan E Lind, Barbara Witek, Ruth H Palmer

EMBO J· February 2021

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11q Deletion or ALK Activity Curbs DLG2 Expression to Maintain an Undifferentiated State in Neuroblastoma.
Joachim Tetteh Siaw, Niloufar Javanmardi, Jimmy Van den Eynden, Dan Emil Lind, Susanne Fransson, Ruth H Palmer

Cell Rep· September 2020

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