Publications by authors named "Scott Dax"

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The discovery and preclinical pharmacology of JNJ-10450232 (NTM-006), a centrally penetrant, non-opioid structural analog of acetaminophen with comparable analgesic and anti-pyretic properties but no evidence of hepatotoxicity.
Christopher M Flores, John R Carson, Ellen E Codd, Scott L Dax, Edwin K Kuffner

Regul Toxicol Pharmacol· April 2025

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Identification and Characterization of GAL-021 as a Novel Breathing Control Modulator.
Francis J Golder, Scott Dax, Santhosh M Baby, Ryan Gruber, Toshinori Hoshi

Anesthesiology· November 2015

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Benzo[d]imidazole Transient Receptor Potential Vanilloid 1 Antagonists for the Treatment of Pain: Discovery of trans-2-(2-{2-[2-(4-Trifluoromethyl-phenyl)-vinyl]-1H-benzimidazol-5-yl}-phenyl)-propan-2-ol (Mavatrep).
William H Parsons, Raul R Calvo, Wing Cheung, Yu-Kai Lee, Sharmila Patel, Scott L Dax

J Med Chem· May 2015

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Arylglycine derivatives as potent transient receptor potential melastatin 8 (TRPM8) antagonists.
Bin Zhu, Mingde Xia, Xiaoqing Xu, Donald W Ludovici, Manomi Tennakoon, Scott L Dax

Bioorg Med Chem Lett· April 2013

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The design and synthesis of novel, phosphonate-containing transient receptor potential melastatin 8 (TRPM8) antagonists.
Jay M Matthews, Ning Qin, Raymond W Colburn, Scott L Dax, Mike Hawkins

Bioorg Med Chem Lett· April 2012

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Diabetogenic effect of a series of tricyclic delta opioid agonists structurally related to cyproheptadine.
Ellen E Codd, Judith Baker, Michael R Brandt, Stewart Bryant, Chaozhong Cai, Scott L Dax

Toxicol Sci· October 2010

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JNJ-20788560 [9-(8-azabicyclo[3.2.1]oct-3-ylidene)-9H-xanthene-3-carboxylic acid diethylamide], a selective delta opioid receptor agonist, is a potent and efficacious antihyperalgesic agent that does not produce respiratory depression, pharmacologic tolerance, or physical dependence.
Ellen E Codd, John R Carson, Raymond W Colburn, Dennis J Stone, Christopher R Van Besien, Scott L Dax

J Pharmacol Exp Ther· April 2009

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N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1).
Michele C Jetter, James J McNally, Mark A Youngman, Mark E McDonnell, Adrienne E Dubin, Scott L Dax

Bioorg Med Chem Lett· April 2008

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Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.
Michele C Jetter, Mark A Youngman, James J McNally, Mark E McDonnell, Sui-Po Zhang, Scott L Dax

Bioorg Med Chem Lett· November 2007

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Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Devin M Swanson, Adrienne E Dubin, Chandra Shah, Nadia Nasser, Leon Chang, Scott L Dax

J Med Chem· March 2005

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Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists.
Steven J Coats, Mark J Schulz, John R Carson, Ellen E Codd, Dennis J Hlasta, Scott L Dax

Bioorg Med Chem Lett· November 2004

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N-isoquinolin-5-yl-N'-aralkyl-urea and -amide antagonists of human vanilloid receptor 1.
Michele C Jetter, Mark A Youngman, James J McNally, Sui-Po Zhang, Adrienne E Dubin, Scott L Dax

Bioorg Med Chem Lett· June 2004

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N,N-dialkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, potent, selective delta opioid agonists.
John R Carson, Steven J Coats, Ellen E Codd, Scott L Dax, Jung Lee

Bioorg Med Chem Lett· May 2004

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N-alkyl-4-[(8-azabicyclo[3.2.1]-oct-3-ylidene)phenylmethyl]benzamides, micro and delta opioid agonists: a micro address.
John R Carson, Steven J Coats, Ellen E Codd, Scott L Dax, Jung Lee

Bioorg Med Chem Lett· May 2004

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Novel non-peptidic neuropeptide Y Y2 receptor antagonists.
Jill A Jablonowski, Wenying Chai, Xiaobing Li, Dale A Rudolph, William V Murray, Scott L Dax

Bioorg Med Chem Lett· March 2004

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7-Hydroxynaphthalen-1-yl-urea and -amide antagonists of human vanilloid receptor 1.
Mark E McDonnell, Sui Po Zhang, Nadia Nasser, Adrienne E Dubin, Scott L Dax

Bioorg Med Chem Lett· January 2004

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Design and synthesis of novel pyrrolidine-containing bradykinin antagonists.
Jung Lee, Charles Reynolds, Michele C Jetter, Mark A Youngman, Dennis J Hlasta, Scott L Dax

Bioorg Med Chem Lett· June 2003

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Synthesis and structure--activity relationships of aroylpyrrole alkylamide bradykinin (B2) antagonists.
Mark A Youngman, John R Carson, Jung S Lee, Scott L Dax, Sui-Po Zhang

Bioorg Med Chem Lett· April 2003

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Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.
Mark E McDonnell, Sui Po Zhang, Adrienne E Dubin, Scott L Dax

Bioorg Med Chem Lett· April 2002

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